Knockout News and Research

RSS

Menin protein protects against aging and cognitive decline

In a recent study published in the journal PLoS Biology, researchers from the University of Xiamen, China, explored the role of the hypothalamic menin in driving aging and associated cognitive decay.

23 Mar 2023

Study focuses on new approach that delivers a "one-two punch" to help T cells attack solid tumors

A new approach that delivers a "one-two punch" to help T cells attack solid tumors is the focus of a preclinical study by researchers from the Perelman School of Medicine at the University of Pennsylvania.

15 Mar 2023

An emerging target for chronic kidney disease treatment - DNA-PKcs

A recent Nature Communications study suggested that DNA-PKcs could be a potential target for treating chronic kidney disease.

15 Mar 2023

XBP1s plays a key role in controlling IL-15-mediated NK cell survival, study shows

A new study published in Science Immunology points to a promising therapeutic approach for future cancer treatments based on natural killer cells (NK), which are immune cells that bind to tumor cells and destroy them.

14 Mar 2023

Using convolutional neural network to automate the identification of chromatid cohesion defects

Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion.

13 Mar 2023

Study sheds new light on a key protein involved in the process of spermiation

In order to achieve good times in their races, many Olympic swimmers wear swimsuits that are low in water resistance.

13 Mar 2023

Study indicates that macrophages that reside in the lymph nodes contribute to the initial Zika virus spread

Researchers mapped Zika virus infections in the lymph nodes to determine how the Zika virus enters from different points in the skin and disseminates through the body.

20 Feb 2023

New research could help explain how sense of smell is impacted in individuals with autism

New research from New York Institute of Technology College of Osteopathic Medicine could help explain how the sense of smell is impacted in individuals with autism.

14 Feb 2023

β-damascone can function as an efficient modulator of dendritic cell-mediated functions

Dendritic cells (DCs) are important players of the immune system with important functions such as the identification of infectious pathogens, production of cytokines (chemical signalers of the immune system), presentation of antigens to activate T-cells, and more.

10 Feb 2023

Casein-based diet found to protect diabetic mice against autoimmunity

Researchers studied diet-commensal microbial interactions in autoimmunity.

10 Feb 2023

Repression of endothelial TLR3 is a potential mechanism of SARS-CoV-2 infection-associated lung vascular remodeling

Researchers investigated whether endothelial TLR3 insufficiency contributes to lung vascular remodeling induced by SARS-CoV-2.

30 Jan 2023

Serotonin can potentially accelerate degenerative mitral regurgitation, study says

Serotonin can impact the mitral valve of the heart and potentially accelerate a cardiac condition known as degenerative mitral regurgitation, according to a new study led by researchers at Columbia University's Department of Surgery in collaboration with the Pediatric Heart Valve Center at Children's Hospital of Philadelphia, the University of Pennsylvania, and the Valley Hospital Heart Institute.

29 Jan 2023

Artificial light affects glucose metabolism

Researchers assess the hypothalamus as a possible mediator of the effect of light on metabolism.

24 Jan 2023

Study reveals the mechanism through which Sirtuin 7 protein suppresses thermogenesis in mice

Mammals convert the energy stored in adipose (fat) tissue into heat via a process known as thermogenesis.

20 Jan 2023

10 years of CRISPR genome editing: Advances, limitations, and future potential

In the decade since the publication of CRISPR-Cas9 as a genome editing technology, the CRISPR toolbox and its applications have profoundly changed biological research, enabling advances through applications in plants, animals, and humans.

20 Jan 2023

The diverse mechanisms by which galectins can regulate adaptive and innate immune responses

Researchers explored ways galectins can impact immunity and discussed the opportunities and challenges in the field.

18 Jan 2023

Study suggests a link between the protein-coding gene TREM2 and obesity in females

A recent Scientific Reports study has investigated the link between TREM2 expression and human obesity, based on two large public datasets, namely, the UK Biobank (UKB) and the Genotype-Tissue Expression (GTEx) project.

11 Jan 2023

New research on DNA-repair enzyme could help enhance cancer drug development

Researchers from Rice University and St. Jude Children's Research Hospital in Memphis, Tennessee, took a close look at one of ways cells repair broken strands of DNA and discovered details that could help make a particular enzyme a promising target for precision cancer therapy.

6 Jan 2023

Researchers reveal previously unknown properties of T cells

Certain T cells can secrete cytokines that are normally part of the innate immune system, as researchers from the Leibniz Institute for Natural Product Research and Infection Biology and an international research team discovered.

5 Jan 2023

What is the role of SARS-CoV-2 non-structural protein 2 in repressing host antiviral immunity?

Researchers uncovered a novel mechanism that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses (CoVs) use to exploit host antiviral immune system to facilitate their replication.