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Oligodendrocytes identified as key amyloid β producers in Alzheimer's disease

Researchers discovered that oligodendrocytes, not just neurons, produce amyloid β in Alzheimer's disease, and suppressing their activity improves disease pathology. This finding suggests new therapeutic targets for Alzheimer's treatment.

24 Jul 2024

New preclinical model offers a unique platform for studying Parkinson's disease process

A new preclinical model offers a unique platform for studying the Parkinson's disease process and suggests a relatively easy method for detecting the disease in people, according to a new study led by Weill Cornell Medicine researchers.

23 Jul 2024

CD5 knockout using CRISPR boosts CAR T cell therapy efficacy

The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, a protein found on the surface of T cells, according to a preclinical study from investigators at the University of Pennsylvania's Perelman School of Medicine and Abramson Cancer Center.

19 Jul 2024

Blocking IL-11 protein extends lifespan and health in mice by 25%, study shows

Scientists at the Medical Research Council Laboratory of Medical Science and Imperial College London have discovered that 'switching off' a protein called IL-11 can significantly increase the healthy lifespan of mice by almost 25%.

18 Jul 2024

Scientists identify over 5,000 genetic variants that enable certain cancers to thrive

Researchers performed saturation genome editing of the BAP1, whose dysfunction is related to cancer and impaired neurodevelopment.

10 Jul 2024

Novel antiviral protein SAMD9L blocks HIV-1 and other lentiviruses

Researchers discovered that interferon-stimulated SAMD9L restricts HIV-1 and other lentiviruses by inhibiting viral translation and endosomal trafficking, while SAMD9 enhances HIV-1 replication.

7 Jul 2024

Heparan-sulfate proteoglycans found to influence Alzheimer's cell pathology

The impact of heparan-sulfate-modified proteoglycans (HSPGs) on Alzheimer's disease-associated pathways.

5 Jul 2024

“G900” gene enhancers may play a pivotal role in asthma-associated inflammation

Type-2 helper T (Th2) cells play intricate roles in the inflammatory response underlying asthma. Elevated levels of the protein GATA3 stimulate the maturation of these cells. Consequently, gene regions known as enhancers, which enhance the expression of the GATA3 gene, have been implicated in asthma-associated inflammation.

26 Jun 2024

Study links gene regulation to allergic airway inflammation

Asthma patients experience respiratory distress due to allergens like house dust mites or pollen. However, the various triggers for asthma share a common pathway involving the release of proteins called type-2 cytokines by Type-2 helper T (Th2) cells and group-2 innate lymphoid cells (ILC2s). Both Th2 and ILC2 require high amounts of GATA-binding protein 3 (GATA3) for their maturation.

25 Jun 2024

Study sheds light on the role of signaling pathway in the brain to prevent neuroinflammation

A new study led by University of Cincinnati researchers sheds new light on the role of a signaling pathway in the brain to maintain health and prevent inflammation and cognitive deficits.

24 Jun 2024

KU researchers uncover role of Src gene in nervous system development

Many people are familiar with oncogenes -; genes long known to be involved in cancers in humans, such as the gene "Src."

24 Jun 2024

UT Health San Antonio researcher wins NIH grant to investigate alcohol-associated liver disease

Liver transplants associated with alcohol-related disease are growing at a rapid pace, shifting research to address pathologies behind the ailments in light of a limited supply of organ donors.

21 Jun 2024

Study reveals critical role of ADGRF5 in maintaining glomerular filtration barrier integrity

Glomerulus, the fundamental filtering unit of the kidney, is an intricate network of capillaries -; small blood vessels that regulate the movement of ions, water, and metabolites while maintaining impermeability to essential macromolecules such as proteins.

21 Jun 2024

Study unlocks the secrets of mammalian longevity through DNA methylation analysis

Researchers developed DNA methylation-based models predicting maximum lifespan, gestation, and sexual maturity across 348 mammalian species, revealing key epigenetic markers of longevity.

10 Jun 2024

Statins found to prevent chronic inflammation-related cancers by inhibiting interleukin-33

The effects of statins via inhibition of interleukin 33 (IL-33).

3 Jun 2024

Canagliflozin enhances senescent cell clearance, improving aging-related conditions

Whether sodium-glucose co-transporter 2 (SGLT2) inhibitors induce senolysis.

3 Jun 2024

New strategy targets rare B cells for effective HIV vaccine development

Germline-targeting epitope scaffold nanoparticles elicit rare broadly neutralizing antibody (bnAb) precursors against human immunodeficiency virus (HIV).

3 Jun 2024

Study finds Plexin-B1 could be key to Alzheimer’s treatment, enhancing glial cell response

Researchers discovered that Plexin-B1 plays a crucial role in regulating peri-plaque glial nets in Alzheimer’s disease, potentially opening new avenues for treatment by targeting this protein.

29 May 2024

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

A new paper in Trends in Pharmacological Sciences from researchers at generative artificial intelligence (AI)- and robotics-powered clinical stage drug discovery company Insilico Medicine ("Insilico") and ETH Zurich reveals the broad potential of TNIK as a therapeutic target for some of the most pervasive aging-related diseases, including fibrosis, cancer, obesity, and Alzheimer's.

28 May 2024

Non-hormonal sperm-specific approach offers a promising option for reversible male contraception

The world's population has increased by more than 2.6-fold in the last 60 years. The growing trend continues – projections indicate that the number of people living on our planet will grow to 9 billion by 2037 from 8 billion in 2022.

23 May 2024

Knockout News and Research

Oligodendrocytes identified as key amyloid β producers in Alzheimer's disease

New preclinical model offers a unique platform for studying Parkinson's disease process

CD5 knockout using CRISPR boosts CAR T cell therapy efficacy

Blocking IL-11 protein extends lifespan and health in mice by 25%, study shows

Scientists identify over 5,000 genetic variants that enable certain cancers to thrive

Novel antiviral protein SAMD9L blocks HIV-1 and other lentiviruses

Heparan-sulfate proteoglycans found to influence Alzheimer's cell pathology

“G900” gene enhancers may play a pivotal role in asthma-associated inflammation

Study links gene regulation to allergic airway inflammation

Study sheds light on the role of signaling pathway in the brain to prevent neuroinflammation

KU researchers uncover role of Src gene in nervous system development

UT Health San Antonio researcher wins NIH grant to investigate alcohol-associated liver disease

Study reveals critical role of ADGRF5 in maintaining glomerular filtration barrier integrity

Study unlocks the secrets of mammalian longevity through DNA methylation analysis

Statins found to prevent chronic inflammation-related cancers by inhibiting interleukin-33

Canagliflozin enhances senescent cell clearance, improving aging-related conditions

New strategy targets rare B cells for effective HIV vaccine development

Study finds Plexin-B1 could be key to Alzheimer’s treatment, enhancing glial cell response

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

Non-hormonal sperm-specific approach offers a promising option for reversible male contraception

E-Cigarettes and Ethanol: A forensic Perspective on Vaping

Understanding Consumer-Consented Data to Optimize Digital Health Programs

The Future is Wearable: Advancing Human Health Through Portable Spectroscopy

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