Leptin News and Research

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Leptin is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. It is one of the most important adipose derived hormones. The ''Ob(Lep)'' gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans.

Discovery of protein complex that plays important role in organ formation, cellular development and cicatrisation processes

Cellular movements are essential in organ formation processes, in cellular development and cicatrisation processes.

18 Jan 2007

Fat-hormone leptin may enhance the growth of colonic cancers

Tests on three human colon cancer cell lines showed that the fat-hormone 'leptin' may enhance the growth of colonic cancers. This finding could show why obese people are at increased risk of colon cancer.

10 Jan 2007

A central thermogenic-like mechanism in feeding regulation

During periods of fasting, brain cells responsible for stimulating the appetite make sure that you stay hungry.

2 Jan 2007

Overweight in middle age could mean dementia later in life

To add further fuel to the debate over obesity, researchers in France are saying that being overweight in middle age may indicate a higher risk of dementia later in life.

10 Oct 2006

Leptin could combat type 2 diabetes

University of Florida researchers have discovered the appetite-controlling hormone leptin could also combat type 2 diabetes, a disease that has become a growing problem in the United States as more Americans pack on extra pounds.

21 Sep 2006

New research could help women facing high risk of stillbirth

The risk of stillbirth is particularly high for women with Type 1 or Type 2 diabetes who suffer four times as many stillbirths as non-diabetic women.

5 Sep 2006

Disabling carbohydrate trigger reduces obesity and appetite

Until about 15 years ago, insulin was believed primarily responsible for turning carbohydrates into fat. But then it became apparent that diet alone could stimulate glucose metabolism and fat synthesis, even when insulin levels were low or absent.

30 Aug 2006

Sleep deprivation doubles risks of obesity in both children and adults

Research by Warwick Medical School at the University of Warwick has found that sleep deprivation is associated with an almost a two-fold increased risk of being obese for both children and adults.

19 Jul 2006

Lack of sleep associated with obesity in both children and adults

Research by Warwick Medical School at the University of Warwick has found that sleep deprivation is associated with an almost a two-fold increased risk of being obese for both children and adults.

12 Jul 2006

Body measures and colon cancer risk

Men and women with a large waist circumference and a large waist-to-hip ratio (WHR) have an increased risk of developing colon cancer. In contrast, only in men is a high body mass index (BMI) clearly associated with a higher colon cancer risk.

4 Jul 2006

Ghrelin involved in development of diabetes

Ghrelin, a hormone long considered a key player in obesity, may instead take a major role in maintaining the balance between insulin and glucose and the development of diabetes, said Baylor College of Medicine researchers in a report in the current issue of the journal Cell Metabolism.

11 May 2006

New research links metabolism and appetite suppression, opening door to obesity treatments

A team led by a Canadian researcher has discovered a process by which a small protein acts directly within muscles to increase the body's metabolism to burn fat while simultaneously suppressing appetite.

19 Apr 2006

Hap1 protein could lead to future drug targets for eating disorders

Researchers have discovered how the protein Hap1, which is abundant in the brain's hypothalamus, serves as the link between circulating insulin in the blood and the neural circuitry that controls feeding behavior in mice.

16 Apr 2006

The less a child sleeps, the more likely he or she is to become overweight

The risk of becoming overweight is 3.5 times higher in children who get less sleep than in those who sleep a lot, according to researchers Jean-Philippe Chaput, Marc Brunet, and Angelo Tremblay.

16 Apr 2006

Research provides clues to obesity's cause

Hot fudge sundaes and french fries aside, new research suggests obesity is due at least in part to an attraction between leptin, the hormone that signals the brain when to stop eating, and a protein more recently associated with heart disease.

13 Apr 2006

Leptin may lead to new approaches for curbing appetite

11 Apr 2006

Pigs help study of links between polycystic ovary syndrome, obesity, cardiovascular disease and diabetes

Despite the exaggerated, wrinkly snout and long, coarse, spiky hair reminiscent of the 1980s television space alien ALF, some very special swine are helping researchers at Purdue and Indiana universities understand human infertility, diabetes and cardiovascular disease.

4 Apr 2006

Diabetes more likely if you sleep too much or too little

Men who sleep too much or too little are at an increased risk of developing Type 2 diabetes, according to a study by the New England Research Institutes in collaboration with Yale School of Medicine researchers.

27 Mar 2006

Association between leptin and asthma in adults

Women with high levels of an inflammatory protein produced by fat tissue are at significantly increased risk of asthma, finds research in published ahead of print in Thorax.

15 Mar 2006

Scientists exploit novel route to reverse enlarged hearts in obese mice

Working on genetically engineered obese mice with seriously thickened hearts, a condition call cardiac hypertrophy, scientists at Johns Hopkins have used a nerve protection and growth factor on the heart to mimic the activity of the brain hormone leptin, dramatically reducing the size of the heart muscle.

13 Mar 2006