Leptin News and Research

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Leptin is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. It is one of the most important adipose derived hormones. The ''Ob(Lep)'' gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans.

Research into a protein for treatment of cancer brings prestigious award

Although primarily known for its roles in obesity and reproduction, the protein leptin has been linked to breast cancer in a study which is the recipient of the prestigious Susan G. Komen Foundation award.

28 Jun 2005

People who smoke or are obese are biologically older than slim individuals and non-smokers

Obesity and smoking are important risk factors for many age-related diseases. Tim Spector (St. Thomas’ Hospital, UK) and colleagues in the USA looked for evidence of ageing at a molecular level in smokers and obese individuals.

13 Jun 2005

Poor diet during pregnancy increases risk of child being obese

It is common knowledge that a well balanced diet in pregnancy is crucial, but now scientists say they believe a poor diet during pregnancy appears to raise the chances of having an obese child.

12 Jun 2005

Unique therapeutic strategy to combat cachexia

Researchers at Oregon Health & Science University's Doernbecher Children's Hospital have uncovered a unique therapeutic strategy to combat cachexia - severe malnutrition and physical wasting away - in children and adults with chronic kidney disease (CKD). The study is published in the June issue of the Journal of Clinical Investigation.

9 Jun 2005

Missing link between mothers' diets and obesity in kids

New work may have found the missing link between mothers' diets and obesity in kids. A study published in the June issue of Cell Metabolism suggests that a hormone may explain the connection between mothers who are poorly nourished and an increased risk of obesity in their children.

8 Jun 2005

Obesity appears to worsen and possibly cause asthma

Obesity is a known risk factor for type II diabetes, heart disease and some forms of cancer. Evidence is now mounting that obesity is also a risk factor for asthma.

10 May 2005

Many lives may be saved by new blood test for ovarian cancer

A new blood test which has the potential to save many lives has been developed to detect ovarian cancer, a disease known as the silent killer because it is so difficult to identify.

9 May 2005

MRI study shows hormone leptin alters brains, may ease cravings of people with obesity gene

A magnetic resonance imaging (MRI) study finds that the protein hormone leptin promotes development of gray matter in the part of the brain that regulates cravings and the ability to monitor personal behavior.

4 May 2005

Brain system that controls the sleep/wake cycle might also play a role in regulating appetite and metabolism

A new mouse study suggests that a brain system that controls the sleep/wake cycle might also play a role in regulating appetite and metabolism. Mice with a mutation in a gene called "Clock," which helps drive circadian rhythm, ate significantly more and gained more weight.

22 Apr 2005

Researchers study radiation blockers while conducting nuclear imaging of Iodine uptake in mouse tissues

Scientists have found that a dose five times higher than the FDA-recommended dosage of potassium iodide in the event of a nuclear accident is needed to protect small animals effectively from radioactive iodide in medical imaging procedures. The long-term animal nuclear imaging project is being conducted by a collaboration of biology and physics researchers from the Department of Energy's Jefferson Lab and The College of William & Mary (CWM).

20 Apr 2005

Body fat may promote inflammation

Why does extra fat around the waist increase the risk of heart disease? A new study by Wake Forest University Baptist Medical Center researchers and colleagues suggests that inflammation may be the key.

28 Mar 2005

Vegetarians who don't cook their food have abnormally low bone mass

Vegetarians who don't cook their food have abnormally low bone mass, usually a sign of osteoporosis and increased fracture risk. But a research team at Washington University School of Medicine in St. Louis also found that raw food vegetarians have other biological markers indicating their bones, although light in weight, may be healthy.

28 Mar 2005

Q. What turns an obese person into a person with diabetes? - A. Leptin

Twin epidemics of obesity and type 2 diabetes are bearing down on the world's population, threatening the lives of hundreds of millions of people. But scientists are still trying to determine how the two conditions are linked, and what it takes to turn an obese person into a person with diabetes.

16 Mar 2005

Beta blocker lowers blood pressure and wards off repeat heart attacks

A form of beta blocker, a drug commonly used to lower blood pressure and ward off repeat heart attacks, may provide the answer to preventing osteoporosis, said a Baylor College of Medicine researcher.

20 Feb 2005

The role body fat plays in determining one's risk of chronic diseases

As the prevalence of obesity in America approaches epidemic proportions, researchers are scrambling to learn more about how the body stores fat, how fat tissues affect body systems and the role body fat plays in determining one's risk of chronic diseases.

27 Jan 2005

Insight into potential mechanisms underlying type II diabetes

New research published in the premier issue of Cell Metabolism finds that a single brain region is sufficient for normal control of blood sugar and activity level by the fat hormone leptin. The same region also exerts significant, though more modest, control over leptin's effects on body weight.

19 Jan 2005

Research suggests that lack of sleep may be contributing to the obesity pandemic

The recent rise in obesity may be partly due to the reduced amount of time we spend asleep, according to new research from the University of Bristol, UK.

6 Dec 2004

Battle of Waterloo could help doctors fight death from multiple organ failure

Waterloo’s battlefield is reigniting the debate about whether modern medicine is always good for you, according to University College London (UCL) scientists who are launching a study of why some critically ill patients recover and others die from multiple organ failure - the number one killer of patients in intensive care.

23 Nov 2004

Shp2 protein plays a critical role in obesity

A team of researchers led by The Burnham Institute's Gen-Sheng Feng, Ph.D. has discovered that a protein called Shp2 plays a critical role in obesity.

11 Nov 2004

Brain protein called MC4R that plays a role in the urge to eat has now been found to influence appetite in a second way

A brain protein already known to play a central role in the "feast or fast" signaling that controls the urge to eat has now been found to influence appetite in a second way. The discovery identifies a potential new target for drugs against obesity.

19 Oct 2004