Leucine News and Research

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Genetic factors that make the bacteria behind cholera so dangerous uncovered

Study reveals key genetic factors in Vibrio cholerae O1 that drive cholera transmission and severity, highlighting targets for novel therapeutic strategies.

26 Sep 2024

New consensus on assessing carcinogenic risks of gene therapies

A new article in the peer-reviewed journal Human Gene Therapy describes the consensus reached by invited experts who participated in a meeting to evaluate the potential carcinogenicity of gene therapies.

30 Aug 2024

Mediterranean diet lowers COVID-19 risk, but its effect on symptoms and severity remains uncertain

Higher adherence to the Mediterranean diet is associated with a reduced risk of COVID-19, but its effects on symptom severity are less certain due to mixed results and study limitations.

27 Aug 2024

mRNA therapy shows promise for maple syrup urine disease

Researchers from the University of Pennsylvania, Perelman School of Medicine, Gene Therapy Program, and Moderna, have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine disease (MSUD).

22 Aug 2024

High-protein diets: How they affect weight, energy, and blood sugar levels

Researchers review the effects of dietary protein on energy intake, appetite, and postprandial glycemia.

21 Aug 2024

Cytomegalovirus in breast milk linked to changes in infant growth and gut microbiome

Research shows human cytomegalovirus (CMV) reactivation in breast milk affects milk composition, infant gut microbiome, and growth, with potential impacts on neonatal health.

28 Jul 2024

How short-term nighttime carb restriction boosts exercise and burns fat

Dietary modifications, like the sleep-low method, may improve exercise performance by optimizing glycogen storage and fat metabolism. A study in Nutrients shows night-time carbohydrate restriction benefits endurance and weight management.

10 Jul 2024

White blood cell type identified as important contributor to inflammation in obesity

Researchers explored neutrophil involvement in visceral adipose tissue (VAT) inflammation in obesity.

3 Jul 2024

Regulatory T cells exist as large, mobile population that travels through body to repair damaged tissue

Researchers investigated populations of regulatory T cells, a type of white blood cell, in various tissues.

1 Jul 2024

Researchers engineer water-soluble histidine kinase for enhanced antibiotic drug screens

A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.

11 Jun 2024

Study links PFAS exposure to increased cardiovascular disease risk in postmenopausal women

New research from the University of Illinois Urbana-Champaign has linked multiple types of per- and polyfluoroalkyl substances (PFAS, also known as "forever chemicals") with increased risk of cardiovascular diseases in postmenopausal women.

5 Jun 2024

New molecular analysis unravels the biological mechanisms of pediatric brain tumors

A study conducted by researchers from the D'Or Institute for Research and Education (IDOR) and the Rede D'Or Pathological Anatomy in conjunction with several North American institutions, including the National Cancer Institute (NIH), used new molecular analyses to unravel the biological mechanisms of pediatric brain tumors and refine their classification.

30 May 2024

Genetic link identified between inflammatory bowel disease and Parkinson's disease

The researchers found, as expected from prior studies that LRRK2 is associated with IBD-PD and discovered new associations as well.

15 May 2024

Newly discovered molecule may be a potential therapeutic target for triple-negative breast cancer

A team of researchers from Hiroshima University has discovered a molecule that promotes the production of cancer cells. This molecule may prove to be a potential therapeutic target in the treatment of triple-negative breast cancer, an aggressive form of breast cancer.

27 Mar 2024

Study uncovers unexpected level of complexity hidden within neutrophils

In a study published in Cell on March 5, Prof. Zhang Xiaoming at the Shanghai Institute of Immunity and Infection (SIII) of the Chinese Academy of Sciences and Profs. Gao Qiang, Fan Jia and Yang Li at Fudan University have uncovered an unexpected level of complexity hidden within neutrophils, which were previously thought to be a relatively uniform population of short-lived immune cells.

6 Mar 2024

Leucine News and Research

Genetic factors that make the bacteria behind cholera so dangerous uncovered

New consensus on assessing carcinogenic risks of gene therapies

Mediterranean diet lowers COVID-19 risk, but its effect on symptoms and severity remains uncertain

mRNA therapy shows promise for maple syrup urine disease

High-protein diets: How they affect weight, energy, and blood sugar levels

Cytomegalovirus in breast milk linked to changes in infant growth and gut microbiome

How short-term nighttime carb restriction boosts exercise and burns fat

White blood cell type identified as important contributor to inflammation in obesity

Regulatory T cells exist as large, mobile population that travels through body to repair damaged tissue

Researchers engineer water-soluble histidine kinase for enhanced antibiotic drug screens

Study links PFAS exposure to increased cardiovascular disease risk in postmenopausal women

New molecular analysis unravels the biological mechanisms of pediatric brain tumors

Genetic link identified between inflammatory bowel disease and Parkinson's disease

Newly discovered molecule may be a potential therapeutic target for triple-negative breast cancer

Study uncovers unexpected level of complexity hidden within neutrophils

Dietary protein overload linked to increased atherosclerosis risk

A high-protein diet and elevation in the amino acid leucine may contribute to buildup of plaque in arteries

Healthy lifestyles linked to specific metabolic markers, large study finds

Study explores the mediatory role of gut microbiota in metabolic syndrome and sleep disorders

Neonates exposed to SARS-CoV-2 in utero at higher risk of respiratory distress, study finds

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

Automating research - solutions and best practices

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