Leukocyte News and Research

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Patients with rheumatoid arthritis are at increased risk of coronary artery disease

The findings of research published today in Arthritis Research & Therapy show that CAD is accelerated in RA patients, and patients with both RA and CAD are at an increased risk of death from heart disease.

28 Jun 2005

Scientists have discovered how C-reactive protein is able to access endothelial cells

For the first time, scientists have discovered how C-reactive protein, or CRP, is able to access endothelial cells. The UC Davis researchers' findings will be published in the July issue of Arteriosclerosis, Thrombosis, and Vascular Biology, one of the American Heart Association's leading journals.

27 Jun 2005

Scientists solve structure of a critical innate immune system protein

Scientists at The Scripps Research Institute have solved the structure of a crucial human immune system molecule called TLR3, an acronym for Toll-like receptor three. In an upcoming issue of the journal Science, the protein is described as a large horseshoe-shaped coil composed of 23 leucine-rich repeats (LRRs).

27 Jun 2005

Simple analysis of a bone marrow transplant patient's oral rinse indicates whether infection will develop

Simple analysis of a bone marrow transplant patient's oral rinse can give medical personnel a quick indication of the transplant's effectiveness and predict whether an infection will develop, says a University of Toronto researcher.

27 Jun 2005

OHSU scientists say low FOXP3 means fewer disease-fighting cells, but new drug may help multiple sclerosis

Oregon Health & Science University researchers have measured genetic changes reflecting a drop in the body's ability to suppress inflammatory cells that attack nerve fibers and promote progression of multiple sclerosis.

27 Jun 2005

Thalidomide may be a potent anti-cancer treatment

When people hear "thalidomide," many think "birth defects," however, evidence has come to light that this once-banned drug can be used as a potent anti-cancer treatment.

20 Jun 2005

Female bed-rest study will understand changes to the immune response and decreased resistance to infection in space

A bed-rest study with female participants will help scientists understand changes to the immune response and decreased resistance to infection in space.

16 Jun 2005

Immunomedics awarded U.S. and Australian patents

Immunomedics announced that it has received notices that the U.S. and Australian patent offices have allowed claims in respective patent applications covering methods for treating a wide range of autoimmune diseases using monoclonal antibodies that bind to the CD22 antigen present on B-lymphocytes.

16 Jun 2005

European approval of Temodal (temozolomide) capsules for treatment of glioblastoma multiforme

Schering-Plough announced today that the European Commission has granted approval of Temodal (temozolomide) Capsules for first-line use for the treatment of patients with newly diagnosed glioblastoma multiforme (GBM), the most common and aggressive form of primary brain cancer.

10 Jun 2005

Rituximab provides new hope for people with lupus

Rheumatologists at the Annual European Congress of Rheumatology in Vienna, Austria heard today (Thursday 9 June) that rituximab is the first drug in a quarter of a century that is making a real impact, and an alternative to previous standard treatments of high-dose steroids, and chemotherapy.

9 Jun 2005

Superbug possibly the same as US killer strain

Microbiologists at the Health Protection Agency suspect that the superbug which has already caused 12 deaths at Stoke Mandeville Hospital, in Buckinghamshire, may be the same strain that has spread in many American hospitals since 2001, and killed more than 100 patients in Quebec, Canada, last year.

8 Jun 2005

Diversity of HLA genotypes in humans is shaped to a significant degree by pathogens

The great physical diversity that evolution has forged in human beings is in evidence wherever we look, but the genes exhibiting the greatest diversity at the DNA level happen to function in a wholly invisible process: immunity. Genes encoding the Human Leukocyte Antigen (HLA) proteins are among the most diverse in the human genome, and scientists have proposed a number of hypotheses to explain why.

6 Jun 2005

Research findings suggest new treatment strategies for patients with cystic fibrosis

Cells sent to fight infections in the lungs of cystic fibrosis patients actually enhance the development of permanent bacterial infections, according to researchers at National Jewish Medical and Research Center.

3 Jun 2005

Chemo combo increases breast cancer survival

A new Spanish study has found that a combination of chemotherapy drugs can increase the five-year survival rate of women with metastatic, node-positive breast cancer by 7 percent.

2 Jun 2005

Leprosy microbes lead scientists to immune discovery

With the unusual opportunity that human leprosy infections provide for study of human immune responses, scientists have discovered how the body's early warning system prompts a rapid immune response by two separate armies of defensive cells.

29 May 2005

Cyclophosphamide may be a possible therapy for scleroderma

A drug that suppresses the immune system and reduces inflammation has been shown to be effective in treating lung disease associated with the devastating connective tissue disease scleroderma, according to results presented at the American Thoracic Society International Conference on May 23.

24 May 2005

Anti-inflammatory protein annexin 1 may protect patients from the detrimental effects of severe inflammatory response syndrome

Severe inflammatory response syndrome, or SIRS, occurs when the body's response to an overwhelming infection becomes uncontrolled. The very immune response meant to clear the pathogen and its toxins actually causes damage to the host's own tissues when it goes into overdrive, releasing too many immune signals.

23 May 2005

Routine, inexpensive blood test sharpens heart disease risk predictions

Routine measurements of white blood cell counts that provide a ratio of neutrophils to lymphocytes may offer a simple and low-cost way to refine predictions of heart attack or death, according to a new study in the May 17, 2005, issue of the Journal of the American College of Cardiology.

18 May 2005

Zevalin safe and effective for non-Hogdkin's lymphoma patients

According to a University of Pittsburgh Medical Center (UPMC) study, patients with advanced non-Hodgkin's lymphoma (NHL) previously treated with chemotherapy and adult stem cell transplantation can safely tolerate Zevalin (ibritumomab tiuxetan), a radiolabeled monoclonal antibody that targets radiation directly to a tumor.

17 May 2005

Breast cancer chemotherapy regimen associated with life-threatening complications

The chemotherapy regimen of doxorubicin plus docetaxel, used to treat breast cancer in a clinical trial, was associated with an increased risk of serious complications, resulting in the premature termination of the trial, according to a study in the May 18 issue of JAMA.

17 May 2005

Leukocyte News and Research

Patients with rheumatoid arthritis are at increased risk of coronary artery disease

Scientists have discovered how C-reactive protein is able to access endothelial cells

Scientists solve structure of a critical innate immune system protein

Simple analysis of a bone marrow transplant patient's oral rinse indicates whether infection will develop

OHSU scientists say low FOXP3 means fewer disease-fighting cells, but new drug may help multiple sclerosis

Thalidomide may be a potent anti-cancer treatment

Female bed-rest study will understand changes to the immune response and decreased resistance to infection in space

Immunomedics awarded U.S. and Australian patents

European approval of Temodal (temozolomide) capsules for treatment of glioblastoma multiforme

Rituximab provides new hope for people with lupus

Superbug possibly the same as US killer strain

Diversity of HLA genotypes in humans is shaped to a significant degree by pathogens

Research findings suggest new treatment strategies for patients with cystic fibrosis

Chemo combo increases breast cancer survival

Leprosy microbes lead scientists to immune discovery

Cyclophosphamide may be a possible therapy for scleroderma

Anti-inflammatory protein annexin 1 may protect patients from the detrimental effects of severe inflammatory response syndrome

Routine, inexpensive blood test sharpens heart disease risk predictions

Zevalin safe and effective for non-Hogdkin's lymphoma patients

Breast cancer chemotherapy regimen associated with life-threatening complications

Immunology eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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