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GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

A new research paper was published in Oncotarget's Volume 14 on May 19, 2023, entitled, "G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis."

23 May 2023

Study reveals DCAF1 protein's role in colon cancer development through EZH2 phosphorylation

A recent study reveals that DCAF1 is overexpressed and phosphorylates EZH2 in colon cancer cells.

18 Apr 2023

TbID-based proteomic profiling in meiotic cells helps identify proximate proteins in A. thaliana

During meiosis, reshuffling of genetic information between homologous chromosomes through meiotic recombination creates variable gametes and hence genetic variation in offsprings.

13 Mar 2023

PARK2 duplication or microdeletion and neurological diseases

In a recent study published in the Genes journal, researchers assessed the impact of PARK2 duplication or microdeletion on neurological diseases such as Parkinson's.

28 Feb 2023

Study characterizes N-terminal domain structure of a ubiquitin ligase TRAF6

A team of international scientists has recently characterized the structure of tumor necrosis factor receptor associated factor 6 (TRAF6) N-terminal domain for therapeutic purposes.

28 Feb 2023

UIC scientists find new way to better target cellular proteins

By studying how enzymes move from one membrane compartment to another inside a cell, scientists at the University of Illinois Chicago have figured out a way to better target cellular proteins, which play a role in many diseases.

15 Feb 2023

Study identifies new tau regulators as viable therapeutic targets for Alzheimer's and other tauopathies

Neurodegenerative diseases affect millions of people worldwide and as our life expectancy increases, more individuals are expected to be affected in the coming decades.

16 Jan 2023

Research reveals a novel viral strategy in modulating stress granule formation to promote virus infection

Researchers illustrated a novel strategy likely employed by viruses to promote infection.

6 Dec 2022

The effect of ubiquitination on SARS-CoV-2 infection and patient prognosis

A recent Clinical and Translational Medicine study utilized several published public datasets to evaluate the biological characteristics associated with the ubiquitination of patients infected with SARS-CoV-2.

2 Dec 2022

Researchers provide insights on how to overcome resistance in cancer therapy

The latest developmental drugs, particularly for the use in oncology, rely on the targeted degradation of harmful pathogenic proteins.

3 Nov 2022

Association of COVID-19 severity with nasopharyngeal fungal colonization and interleukin-17 induction

Researchers evaluated the concurrent colonization of fungi in the nasopharynx of severe COVID-19 patients.

28 Oct 2022

Researchers provide critical insights into the molecular mechanisms underlying lysophagy

Autophagy is a self-degradation process that cells use to remove unneeded or damaged components. There are several forms of autophagy, including macroautophagy, which is a bulk degradation system used to target materials in the cell's cytosol to organelles called lysosomes for enzymatic breakdown.

20 Sep 2022

Ligase News and Research

GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

Study reveals DCAF1 protein's role in colon cancer development through EZH2 phosphorylation

TbID-based proteomic profiling in meiotic cells helps identify proximate proteins in A. thaliana

PARK2 duplication or microdeletion and neurological diseases

Study characterizes N-terminal domain structure of a ubiquitin ligase TRAF6

UIC scientists find new way to better target cellular proteins

Study identifies new tau regulators as viable therapeutic targets for Alzheimer's and other tauopathies

Research reveals a novel viral strategy in modulating stress granule formation to promote virus infection

The effect of ubiquitination on SARS-CoV-2 infection and patient prognosis

Researchers provide insights on how to overcome resistance in cancer therapy

Association of COVID-19 severity with nasopharyngeal fungal colonization and interleukin-17 induction

Researchers provide critical insights into the molecular mechanisms underlying lysophagy

How does SARS-CoV-2 infection impact fertility in men?

Research suggests a new model of how beige fat biogenesis is controlled

Research progress on the three-dimensional interaction between virus and host genome

Elephant genes could offer new clues to preventing cancer development

SARS-CoV-2 damages cilia

Research looks at potential of pantethine against SARS-CoV-2

Research describes how DNA damage can affect neural health and function

Proximity labeling to identify high-confidence SARS-CoV-2 interactors

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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