Ligase News and Research

RSS

Researchers discover link between FBXW7 mutations and EGFR signaling in colorectal cancer

The Organoid group at the Hubrecht Institute have identified a new link between FBXW7 mutations and EGFR signaling activity.

18 Mar 2024

Unveiling the molecular mechanism responsible for crossover interference during meiosis

Movies such as 'X-Men,' 'Fantastic Four,' and 'The Guardians,' which showcase vibrant mutant heroes, have captivated global audiences.

7 Mar 2024

EPFL scientists uncover protein degradation mechanism preventing autoimmune reactions

Scientists at EPFL uncover the mechanism by which cells mark the protein cGAS for degradation, which is critical in preventing the immune system from mistakenly attacking the body's own tissues.

28 Feb 2024

Intramolecular bivalent glues: A promising avenue for protein degradation

Living cells resemble highly organized small towns - in addition to energy production, transportation systems, and construction, cells also require efficient waste disposal.

21 Feb 2024

Molecular glue could pave the way for new generation of drugs

A breakthrough class of molecular glue identified at the University of Dundee could pave the way for a new generation of drugs to target cancers and neurodegenerative diseases.

21 Feb 2024

IL-17: The molecule that could revolutionize autoimmune and cancer treatments

The research paper explores the multifaceted role of the IL-17 family in immune response, covering everything from infection control to pathological conditions like autoimmune diseases and cancer. Future therapies may exploit IL-17's unique signaling pathways to offer more targeted and cost-effective treatments.

12 Oct 2023

New discovery sheds light on how BRCA1 mutations cause cancer in women

Three decades after discoveries linking mutations in the BRCA1 gene to breast and ovarian cancer susceptibility, research led by Mays Cancer Center at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) has pinpointed the molecular mechanism by which a large portion of these mutations cause cancers in women.

9 Oct 2023

New insights into the molecular mechanism of protein degradation

Within the intricate molecular landscape inside of a cell, the orchestration of proteins demands precise control to avoid disease.

22 Sep 2023

Mitochondrial GTP metabolism acts through mitochondrial dynamics factors to regulate reproductive aging

Reproductive aging in Caenorhabditis elegans is regulated through an interaction of the metabolism of mitochondrial guanosine-triphosphate.

18 Sep 2023

Study reveals how a causal factor in Angelman syndrome eliminates neural chat

Researchers from the University of Tokyo reveal how the presynaptic Ube3a E3 ligase, a causal factor in Angelman syndrome, eliminates neural chat.

14 Sep 2023

Unveiling hidden threats: clustering loops in CAR-T cells impact cancer therapy

How complementarity-determining region (CDR) loops in the single-chain variable fragment (scFv) influence chimeric antigen receptor (CAR)-T cell behavior.

14 Aug 2023

PhoreMost appoints Professor Peter Parker and Dr Jason Imbriglio to Scientific Advisory Board

PhoreMost Ltd. announced Professor Peter Parker and Dr Jason Imbriglio as members of its Scientific Advisory Board (SAB).

From PhoreMost 17 Jul 2023

Plant cell study reveals new role for enzyme in lipid metabolism

A new study by Rice University bioscientists explains how basic cellular structures common to most life forms collaborate to fuel growth in a model plant organism. The findings could shed light on corresponding mechanisms in human cells.

12 Jul 2023

Mutations in AGC kinase motif linked to colorectal cancer growth

Cancer spreads throughout the human body in cunning, almost militaristic, ways. For example, it can manipulate our genetic make-up, take over specific cell-to-cell signaling processes, and mutate key enzymes to promote tumor growth, resist therapies, and hasten its spread from the original site to the bloodstream or other organs.

3 Jul 2023

Ligase News and Research

Researchers discover link between FBXW7 mutations and EGFR signaling in colorectal cancer

Unveiling the molecular mechanism responsible for crossover interference during meiosis

EPFL scientists uncover protein degradation mechanism preventing autoimmune reactions

Intramolecular bivalent glues: A promising avenue for protein degradation

Molecular glue could pave the way for new generation of drugs

IL-17: The molecule that could revolutionize autoimmune and cancer treatments

New discovery sheds light on how BRCA1 mutations cause cancer in women

New insights into the molecular mechanism of protein degradation

Mitochondrial GTP metabolism acts through mitochondrial dynamics factors to regulate reproductive aging

Study reveals how a causal factor in Angelman syndrome eliminates neural chat

Unveiling hidden threats: clustering loops in CAR-T cells impact cancer therapy

PhoreMost appoints Professor Peter Parker and Dr Jason Imbriglio to Scientific Advisory Board

Plant cell study reveals new role for enzyme in lipid metabolism

Mutations in AGC kinase motif linked to colorectal cancer growth

Research explores complex relationship between cholesterol and breast cancer risk

GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

Study reveals DCAF1 protein's role in colon cancer development through EZH2 phosphorylation

TbID-based proteomic profiling in meiotic cells helps identify proximate proteins in A. thaliana

PARK2 duplication or microdeletion and neurological diseases

Study characterizes N-terminal domain structure of a ubiquitin ligase TRAF6

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News