Lipogenesis News and Research

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Lipogenesis is the process by which simple sugars such as glucose are converted to fatty acids, which are subsequently esterified with glycerol to form the triacylglycerols that are packaged in VLDL and secreted from the liver.

Natural obesity fighters: How coffee, tea, and cocoa combat weight gain

A review in Current Research in Food Science explores how bioactive compounds in coffee, tea, and cocoa combat obesity by inhibiting white adipogenesis and promoting brown adipogenesis and lipolysis.

22 Apr 2024

New research pinpoints key pathways in prostate cancer's vulnerability to ferroptosis

Review examines the role of ferroptosis, an iron-dependent form of cell death, in prostate cancer, exploring its underlying molecular mechanisms and potential for targeted therapeutic strategies.

17 Apr 2024

CMS121 holds promise for treating metabolic diseases

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 6, entitled, "CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction."

9 Apr 2024

Breakthrough obesity treatments on the horizon, rivaling surgery's success

New obesity pharmacotherapies, including GLP-1 receptor agonists and combinations of entero-pancreatic hormones, show promise in achieving significant weight loss, potentially rivaling bariatric surgery's effectiveness.

4 Feb 2024

New study pinpoints mitochondria as key player in dietary fat-cancer connection

The research study is entitled "The Central Role of Mitochondria in the Relationship between Dietary Lipids and Cancer Progression". It revealed new findings on the factors that influence the development of diseases, such as the particularly interesting relationship between dietary fats and the development of cancer.

20 Dec 2023

Cinnamon extract shows promise in reducing obesity by inhibiting fat cell growth and boosting fat breakdown

Study reveals that cinnamon extract significantly inhibits adipocyte differentiation and lipid accumulation, offering potential benefits against obesity by reducing fat production and enhancing lipolysis in both cell models and mice.

18 Dec 2023

Study finds key gene deletion shields mice from diet-induced obesity and liver disease

Study in the International Journal of Obesity reveals that BMAL1 deletion in mice protects against obesity and non-alcoholic fatty liver disease caused by a high-fat diet, highlighting its potential as a therapeutic target.

13 Dec 2023

Two kiwi fruit every day safe and can replace vitamin C supplementation

Study investigates the health effects of consuming two kiwifruits daily for six weeks. It finds no significant changes in metabolic and inflammatory biomarkers, indicating that regular kiwifruit consumption is safe and increases dietary vitamin C intake without adversely affecting metabolic health.

27 Nov 2023

How African sleeping sickness melts away body fat: New study sheds light on the role of lipolysis

Researchers find that the T. brucei parasite, responsible for African trypanosomiasis, triggers weight loss by disrupting fat cell lipolysis. The study shows that ATGL enzyme is key to this process, potentially offering a new angle for future research and treatment.

17 Oct 2023

Could plant-based phytonutrients be the secret weapon against obesity?

This comprehensive review in the journal Foods explores the therapeutic potential of phytonutrients in combating obesity. The paper delves into various plant-based compounds like polyphenols, alkaloids, and terpenoids, detailing their mechanisms of action in inhibiting fat accumulation, regulating metabolism, and even altering gut microbiota.

1 Oct 2023

Coffee, fiber, and the Mediterranean diet are key players in fighting nonalcoholic fatty liver disease

Dietary patterns, foods, and nutrients to ameliorate nonalcoholic fatty liver disease (NAFLD).

19 Sep 2023

Is maple syrup the ultimate natural sweetener? Researchers say it's more than just tasty!

Scientists explore the myriad benefits of maple syrup, revealing its nutritional, pharmacological, and sensory advantages over traditional sweeteners. From antioxidant and anti-inflammatory properties to controlling blood sugar and even potential anticancer effects, maple syrup is more than just a tasty topping.

14 Sep 2023

Ketogenic diet shows promise in addressing hormonal imbalance associated with PCOS

Researchers performed a meta-analysis on the impact of ketogenic diets on polycystic ovary syndrome (PCOS).

8 Sep 2023

How effective is the keto diet for managing PCOS?

Scientists discuss the metabolic advantages of the ketogenic diet in the management of polycystic ovarian syndrome.

21 Aug 2023

Newly discovered protein kinase shows promise for establishing future obesity and diabetes treatments

Researchers used genetically modified animal models to investigate the role of the newly discovered Traf2- and NCK-interacting protein kinase (TNIK) in obesity and metabolic dysfunction.

15 Aug 2023

Reversing β-cell failure: A promising approach for type 2 diabetes treatment

Researchers examined current evidence on the reasons and implications of pancreatic beta-cell failure.

3 Aug 2023

The Lancet study unveils exciting findings on retatrutide as a novel treatment for type 2 diabetes

Researchers performed a phase II randomized clinical trial (RCT).

29 Jun 2023

Study reveals contrasting effects of sucralose on insulin and glucose control

Sucralose, a commonly used artificial sweetener, has contrasting effects on insulin secretion and glucose homeostasis. While bolus administration of sucralose enhances insulin secretion and decreases glucose levels, long-term consumption exacerbates insulin resistance and glucose intolerance, particularly in combination with a high-fat diet. The study highlights the involvement of the T1R3-ERK1/2 pathway in sucralose-induced insulin resistance in the liver.

22 Jun 2023

Consuming ultra-processed foods is associated with an increased risk of developing non-alcoholic fatty liver disease

Researchers determined the contribution of ultra-processed food intake to the risk of developing NAFLD.

12 May 2023

What is the association between obesity and insulin resistance in youth and its production of colon-derived acetate, gut-derived hormone secretion, and adipose tissue lipolysis?

Researchers assessed whether insulin resistance and adiposity in youth were linked to the fermentation of dietary fibers.

11 May 2023