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TRPC3 emerges as key player in preventing damage from alcohol-associated liver disease

Excessive alcohol intake is strongly associated with alcohol-associated liver disease (ALD) which accounts for 25% and 30% of deaths from cirrhosis and hepatocellular carcinoma. Impairment of Ca2+ influx and Ca2+-mediated signaling in ALD suggests that Ca2+ channels are important in ALD pathological progression.

16 Jan 2024

Poverty may combine in a synergistic manner with chronic inflammation to reduce health, life expectancy

In the US, approximately 37.9 million people, or 11.4% of the population, lived below the poverty line in 2022.

16 Jan 2024

Natural PLA2 inhibitor from marine fungus combats fatty liver disease by silencing lipotoxic pathways

This new article publication from Acta Pharmaceutica Sinica B, discusses the identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling.

16 Jan 2024

Novel blood test shows promise in detecting early-stage cancers with high accuracy

Researchers develop a novel plasma proteome-based test for early detection of multiple cancers, achieving high accuracy in identifying low-abundance protein biomarkers.

14 Jan 2024

Study explores intratumoral microbiota as a novel frontier in cancer research

Researchers review the role of intratumoral microbiota in cancer development, suggesting its potential in predicting and treating various cancers.

14 Jan 2024

New analysis of cancer cells identifies 370 targets for smarter, personalized treatments

A new, systematic analysis of cancer cells identifies 370 candidate priority drug targets across 27 cancer types, including breast, lung and ovarian cancers.

13 Jan 2024

Exploring the link between pancreatic islet cell loss and age-related health conditions

Researchers from Tokyo Metropolitan University have studied pancreatic islet cell loss in people with no previous pancreatic problems. They identified key trends in the types of cells lost due to islet cell loss in different age groups and sexes, finding that ICL in the elderly population was largely due to insulin-producing beta cell loss.

13 Jan 2024

FDA-approved drug may help to decrease pain after surgery, study finds

Researchers in the Department of Anesthesia and Perioperative Medicine at the Medical University of South Carolina (MUSC) have found that an FDA-approved drug may help to decrease pain after surgery.

12 Jan 2024

3D nanomatrix vascular sheet model for high-throughput atherosclerosis drug testing

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

12 Jan 2024

Artificial intelligence spots risky drinkers for safer surgery

Using artificial intelligence to scan surgery patients' medical records for signs of risky drinking might help spot those whose alcohol use raises their risk of problems during and after an operation, a new study suggests.

12 Jan 2024

Groundbreaking study uncovers hundreds of genetic markers linked to insulin resistance

A genome-wide study of 402,398 individuals identifies 369 SNPs associated with insulin resistance, offering insights into metabolic diseases and potential therapeutic targets.

11 Jan 2024

Promising PET scanner tool developed for rare medullary thyroid cancer

A newly developed PET imaging agent has been found to be effective in identifying medullary thyroid cancer (MTC) in preclinical and clinical studies, according to research published in the January issue of The Journal of Nuclear Medicine.

11 Jan 2024

Extended liver preservation technique shows promise for daytime transplants

Phase II clinical trial evaluates the safety and feasibility of prolonged DHOPE for extending human donor liver preservation to 20 hours, showing potential for facilitating daytime liver transplantation.

11 Jan 2024

Risk of gastrointestinal cancers translates to one in 12 people developing, and one in 16 people dying from, gastrointestinal cancers

Researchers estimated the lifetime risk of gastrointestinal cancer and associated mortality.

11 Jan 2024

mRNA therapy shows promise for curing children's rare liver disease

By exploiting the technology used in Covid-19 vaccines, a team led by UCL, King's College London and Moderna scientists has created an effective therapy for a rare disease, in a study in mice, demonstrating the technology's potential therapeutic use in people.

10 Jan 2024

Study reveals mangos attenuates potential against colon cancer

The chemo-preventive potential of Mangiferin (MF) (mango).

10 Jan 2024

New imaging technique could transform diagnosis and treatment of steatotic liver disease

Steatotic liver disease (SLD), previously known as non-alcoholic fatty liver disease, which includes a range of conditions caused by fat build-up in the liver due to abnormal lipid metabolism, affects about 25% of the population worldwide, making it the most common liver disorder.

9 Jan 2024

SickKids scientists untangle cellular waste buildup in Zellweger Spectrum Disorder

For the first time, a research team at The Hospital for Sick Children (SickKids) has uncovered a way to potentially reduce the amount of toxic cellular waste accumulating in patients with Zellweger Spectrum Disorder (ZSD).

9 Jan 2024

American Heart Association Merit Award fuels three research avenues to tackle heart disease

A physician-scientist from Massachusetts researching whether chemicals naturally occurring in foods could help treat heart disease, a genetics expert from Pennsylvania exploring the molecular mechanisms of lipid metabolism and cardiovascular diseases and a California-based professor of cardiovascular medicine studying how vaping impacts the development of abdominal aortic aneurysms are the most recent American Heart Association Merit Award recipients.

9 Jan 2024

In utero exposure to PFAS affects the unborn child, study suggests

PFAS are chemicals that may cause cancer, diabetes, and other diseases. Research from örebro University now suggests that these chemicals affect people as early as the fetal stage of development.

9 Jan 2024

Liver News and Research

TRPC3 emerges as key player in preventing damage from alcohol-associated liver disease

Poverty may combine in a synergistic manner with chronic inflammation to reduce health, life expectancy

Natural PLA2 inhibitor from marine fungus combats fatty liver disease by silencing lipotoxic pathways

Novel blood test shows promise in detecting early-stage cancers with high accuracy

Study explores intratumoral microbiota as a novel frontier in cancer research

New analysis of cancer cells identifies 370 targets for smarter, personalized treatments

Exploring the link between pancreatic islet cell loss and age-related health conditions

FDA-approved drug may help to decrease pain after surgery, study finds

3D nanomatrix vascular sheet model for high-throughput atherosclerosis drug testing

Artificial intelligence spots risky drinkers for safer surgery

Groundbreaking study uncovers hundreds of genetic markers linked to insulin resistance

Promising PET scanner tool developed for rare medullary thyroid cancer

Extended liver preservation technique shows promise for daytime transplants

Risk of gastrointestinal cancers translates to one in 12 people developing, and one in 16 people dying from, gastrointestinal cancers

mRNA therapy shows promise for curing children's rare liver disease

Study reveals mangos attenuates potential against colon cancer

New imaging technique could transform diagnosis and treatment of steatotic liver disease

SickKids scientists untangle cellular waste buildup in Zellweger Spectrum Disorder

American Heart Association Merit Award fuels three research avenues to tackle heart disease

In utero exposure to PFAS affects the unborn child, study suggests

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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