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Liver transplant recipients develop PTMS, face high risk of cardiovascular disease

Researchers from Israel have determined that more than half of liver transplant recipients develop post-transplantation metabolic syndrome, placing them at greater risk for cardiovascular disease.

7 Jan 2011

Findings of AM095 in various in vitro, in vivo models of fibrotic disease published in JPET

Amira Pharmaceuticals, Inc. announced today the publication of its findings in the Journal of Pharmacology and Experimental Therapeutics which describes the biologic effects and the characterization of AM095, a lysophosphatidic acid receptor 1 antagonist, in various in vitro and in vivo models of fibrotic disease.

6 Jan 2011

Scientists identify prognostic biomarker to treat patients with HCV

Scientists at Inserm and Institut Pasteur have performed biomarker discovery on patients being treated for chronic hepatitis C infection. Their work, published in The Journal of Clinical Investigation, demonstrates that the plasma levels of the protein IP-10 predict, prior to treatment initiation, the efficacy of treatment with pegylated-interferon and ribavirin.

6 Jan 2011

Positive topline results from ZGN-433 Phase 1b study in obesity patients

Zafgen, a pharmaceutical company pioneering novel obesity therapeutics to help the body regain and sustain a lean, healthy state by targeting imbalances in fat metabolism, today announced positive topline results from its Phase 1b study of ZGN-433, a methionine aminopeptidase 2 inhibitor, for the treatment of severe obesity.

6 Jan 2011

Investigators receive two Alpha-1 Foundation grants for research on lung disorder

The Alpha-1 Foundation announced today that it has awarded two research grants to investigators whose research will contribute to our understanding of the causes and mechanisms that give rise to lung disease.

6 Jan 2011

Betulin in birch bark appears to provide metabolic benefits

An ingredient found in abundance in birch bark appears to have an array of metabolic benefits, according to new studies in animals that are reported in the January issue of Cell Metabolism, a Cell Press publication.

5 Jan 2011

ReproCELL to enter collaborative iPS cell-derived hepatocytes R&D agreement with NIBIO

ReproCELL, Inc. (CEO: Chikafumi Yokoyama PhD) announces today that the company will enter a collaborative R&D agreement with the National Institute of Biomedical Innovation (NIBIO; Director General: Koichi Yamanishi; Osaka, Japan), which could offer new hepatocyte derived from human iPS (induced pluripotent stem) cells used for an effective in-vitro drug screening for hepatic toxicity and liver metabolism.

5 Jan 2011

Critical tuning dial for controlling whole body energy

Researchers have found what appears to be a critical tuning dial for controlling whole body energy, according to a new report in the January issue of Cell Metabolism, a Cell Press publication. When energy levels within cells drop, it sets off a series of events designed to increase the amount of calorie-rich dietary fat that the body will absorb.

5 Jan 2011

Alnylam presents ALN-VSP Phase I trial results for liver cancer

Alnylam Pharmaceuticals, a leading RNAi therapeutics company, today presented new clinical data from its ALN-VSP Phase I liver cancer trial in a presentation at the Dana-Farber Cancer Institute in Boston. Results from molecular analysis of human biopsy samples showed achievement of pharmacologically relevant siRNA drug levels in tissues.

5 Jan 2011

Hepatitis A scare at Long Island church

Health officials have warned that parishioners who received Holy Communion during Christmas Mass at a church on Long Island may have been exposed to hepatitis A and may need vaccinated as soon as possible. Particularly those who received Communion at the 10.30am and 12pm (local time) masses on December 25, 2010, at Our Lady of Lourdes Church in Massapequa Park should get the shots.

4 Jan 2011

Fear of the fat promoted to curb obesity

The Australian Medical Association has recommended the use of graphic television advertisements in Victoria to warn people about the risks of eating fatty foods. Rising rates of obesity has prompted these extreme measures. The proposed ads in television and newspaper would cost $25 million and would show the effects of fat on the body’s internal organs. The AMA’s proposals are part of a submission calling for $63 million to fight obesity.

3 Jan 2011

FDA authorizes Juventas' JVS-100 Phase II clinical trial for critical limb ischemia

Juventas Therapeutics, a clinical-stage regenerative medicine company developing novel therapies for cardiovascular disease, announces that the U.S. Food and Drug Administration (FDA) authorized commencement of a Phase II clinical trial evaluating the efficacy and safety of its lead product, JVS-100, for the treatment of critical limb ischemia (CLI).

3 Jan 2011

Tips to prevent a hangover

Dr. Andrew Yacht, director of the division of general medicine and vice chair of medicine for education at Maimonides Medical Center in New York City said, “Alcohol clearly causes hangovers, but why it causes hangovers isn’t very well understood…Part of the suspected cause is dehydration and an electrolyte and hormonal imbalance. Some of the symptoms may be caused by low blood sugar. Or, it may be that the direct toxic effects of alcohol are causing the symptoms.”

2 Jan 2011

Flu worries continue

As number of cases of flu rise in the UK, Health Secretary Andrew Lansley is under pressure to strengthen the flu vaccination campaign. He reinstated a public health “Catch It, Bin It, Kill It” advertising campaign after he was warned by government advisers of the need to improve immunization rates which are at their lowest this winter for many years. It had been discontinued despite helping educate the public to adopt good hygiene habits during last year’s H1N1 swine flu epidemic at a cost of just £609,000. There were 12 more deaths in the last week from flu, bringing the total this winter to 39, the Health Protection Agency (HPA) said today. Thirty-six were killed by H1N1 swine flu, which is the most virulent of the two main flu strains currently circulating. The others died after contracting Influenza B, the other strain. All except one of the 39 were under 65 and four were under five.

2 Jan 2011

Immunitor reports positive safety imm01 clinical trial against tuberculosis

Immune Network Ltd., advises that Immunitor has published data from the first half of the 120-patient imm01 clinical trial of its V5 immunomodulator product against tuberculosis, including difficult-to-treat forms of the disease.

30 Dec 2010

Loyola University offers tips to avoid the misery of New Year's hangover

Exercise and B vitamins can help cure a hangover, but coffee won't help. These are among the tips that Loyola University Health System family physician Dr. Aaron Michelfelder offers to avoid the misery of a New Year's hangover.

30 Dec 2010

Low levels of microbe-killing molecules improve survival rate of people with CGD

Investigators at the National Institutes of Health have observed that the survival rate of people with a rare immunodeficiency disease called chronic granulomatous disease is greatly improved when even very low levels of microbe-killing molecules are present.

30 Dec 2010

Florida Hospital, Sanford-Burnham and Takeda enter obesity research collaboration

Florida Hospital, Sanford-Burnham Medical Research Institute (Sanford-Burnham), and Takeda Pharmaceutical Company Limited (Takeda)(TSE: 4502), announced today that they have signed a research agreement to form a collaboration to discover and evaluate new therapeutic approaches to obesity, a growing worldwide health problem. The partnership aligns complementary strengths in biomedical research, clinical research and drug development to identify and validate obesity- related biomarkers and new peripheral molecular targets of mutual interest.

29 Dec 2010

Molecular interaction between structural HCV protein and protein critical to viral replication identified

Scientists from the Florida campus of The Scripps Research Institute have identified a molecular interaction between a structural hepatitis C virus protein (HCV) and a protein critical to viral replication. This new finding strongly suggests a novel method of inhibiting the production of the virus and a potential new therapeutic target for hepatitis C drug development.

29 Dec 2010

New Year's Eve can be bad for your health

Research has shown that New Year's is the deadliest day of the year for pedestrians. Drinking and walking can be as dangerous as drinking and driving. Trauma surgeon Dr. Thomas Esposito has seen the tragic effects of drunk walking, among his patients and in his own family.

29 Dec 2010

Liver News and Research

Liver transplant recipients develop PTMS, face high risk of cardiovascular disease

Findings of AM095 in various in vitro, in vivo models of fibrotic disease published in JPET

Scientists identify prognostic biomarker to treat patients with HCV

Positive topline results from ZGN-433 Phase 1b study in obesity patients

Investigators receive two Alpha-1 Foundation grants for research on lung disorder

Betulin in birch bark appears to provide metabolic benefits

ReproCELL to enter collaborative iPS cell-derived hepatocytes R&D agreement with NIBIO

Critical tuning dial for controlling whole body energy

Alnylam presents ALN-VSP Phase I trial results for liver cancer

Hepatitis A scare at Long Island church

Fear of the fat promoted to curb obesity

FDA authorizes Juventas' JVS-100 Phase II clinical trial for critical limb ischemia

Tips to prevent a hangover

Flu worries continue

Immunitor reports positive safety imm01 clinical trial against tuberculosis

Loyola University offers tips to avoid the misery of New Year's hangover

Low levels of microbe-killing molecules improve survival rate of people with CGD

Florida Hospital, Sanford-Burnham and Takeda enter obesity research collaboration

Molecular interaction between structural HCV protein and protein critical to viral replication identified

New Year's Eve can be bad for your health

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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