Liver Disease News and Research

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The liver is one of the largest solid organs of the body. It is located in the upper right part of the abdomen. Most of the organ lies under cover of the rib cage.

New approach to treating hepatitis C virus

Last year Peter Sarnow, PhD, professor of microbiology and immunology at the Stanford University School of Medicine, identified a previously unknown mechanism that the hepatitis C virus uses to replicate, yielding a promising new approach to combating the disease-causing virus.

10 Apr 2006

Trends over a decade of pediatric liver transplantation in the U.S.

A new study on children undergoing liver transplants found that although innovative transplant techniques have been developed in recent years, the waitlist times for pediatric transplant candidates have increased compared to the early 1990s.

6 Apr 2006

Radiofrequency ablation is as effective as surgery for small liver tumors

Three-year data shows that radiofrequency ablation is as effective as surgical resection for overall survival and tumor recurrence, for the treatment of single small hepatocellular carcinoma in patients with liver cirrhosis, according to a study presented at the Society of Interventional Radiology's 31st Annual Scientific Meeting.

4 Apr 2006

Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis

The unchecked activity of a cell signaling pathway crucial in embryonic development and the liver's response to injury leads to liver cancer, researchers from Duke University Medical Center and John Hopkins University School of Medicine have found.

4 Apr 2006

Omega-3 fatty acids inhibit the growth of liver cancer cells

Two new studies by a University of Pittsburgh research team suggest that omega-3 fatty acids - substances that are found in high concentrations in fish oils and certain seeds and nuts - significantly inhibit the growth of liver cancer cells.

3 Apr 2006

Exposure to toxins from hazardous waste sites may be a significant risk factor for developing primary biliary cirrhosis

Published in the March 2006 issue of Hepatology, researchers found significant clusters of the disease near Superfund toxic waste sites (SFS) and that the majority of patients in New York City who need liver transplants because of PBC, reside near SFS.

13 Mar 2006

New hepatitis drug much more effective

Chronic infection with the hepatitis B virus (HBV) is responsible for an enormous burden of disease throughout the world, including up to half of all cases of cirrhosis, end-stage liver disease, and hepatocellular carcinoma, a cancer of the liver.

9 Mar 2006

Researchers use new approach to 'break the code' for liver cancer test

Scientists at Birmingham University are using cutting edge technologies to move closer to a blood test that will improve early diagnosis of liver cancer in high risk groups, according to research published in the British Journal of Cancer.

25 Jan 2006

Vaccine candidate for hepatitis C

Researchers at the University of Saskatchewan's Vaccine and Infectious Disease Organization (VIDO) have developed a vaccine candidate for hepatitis C, leading to hope in the fight against a disease for which no vaccines are yet available.

11 Jan 2006

New pathways linking liver disease to changes in the central nervous system

Liver disease is often associated with "sickness behaviors," such as malaise, listlessness, anorexia, difficulty concentrating, and fatigue. In cholestatic liver diseases (where bile production is impaired) such as primary biliary cirrhosis, fatigue occurs in up to 86 percent of patients.

5 Jan 2006

Limitation of combination therapy of Interferon and Ribavirin for older patients with chronic hepatitis C

A new Japanese study examining the effects of combination therapy on older patients with hepatitis C found more adverse effects necessitating discontinuation of treatment, lowering of dosages, and lower long-term benefits in this age group.

5 Jan 2006

Binge drinking amongst young Brit's on the rise

According to experts in the UK, hospitals are being forced to treat record numbers of young people admitted to hospital for drink-related diseases.

28 Dec 2005

Experts unsurprised by level of alcohol abuse

In response to figures on alcohol abuse released this week, Dr Peter Rice, a leading consultant psychiatrist with the NHS Tayside Alcohol Problem Service, said he is not surprised as alcohol-related problems were having a detrimental effect on the lives of too many people across Tayside and Scotland.

21 Dec 2005

Milk thistle extract treatment for liver disease found to be ineffective

Results of high-quality randomized clinical trials have determined that milk thistle extract, a widely used alternative medication, may not have any significant influence on the course of patients with alcoholic liver disease or hepatitis B or C liver disease.

15 Dec 2005

Liver transplants may not be suitable for all cystic fibrosis patients

A new study on patients with cystic fibrosis (CF) who have had abnormal bleeding from ruptured blood vessels in the esophagus (variceal hemorrhage) as a result of liver disease found that transplant may not be indicated if there are no other indications of advanced liver disease.

5 Dec 2005

Drinking lots of coffee and tea can reduce the risk of chronic liver disease

A study published in the American Gastroenterological Association (AGA) journal Gastroenterology found that people at high risk for liver injury may be able to reduce their risk for developing chronic liver disease significantly by drinking more than two cups of coffee or tea daily.

2 Dec 2005

Lifestyle modification should be the first line of treatment for obesity

A new study shows that treatment with a lifestyle modification program of diet, exercise and behavioral therapy when used in combination with the weight loss medication sibutramine (Meridia) resulted in significantly greater weight loss among obese adults than treatment with the medication alone.

28 Nov 2005

Largest hepatitis-C U.S. study defines optimal therapy

Final results of the WIN-R trial,[1] the largest hepatitis C study conducted in U.S. patients, showed that weight-based REBETOL (ribavirin, USP) in combination therapy with PEG-INTRON (peginterferon alfa-2b) achieved significantly higher rates of sustained virologic response (SVR)[2] and lower rates of relapse compared to the combination therapy using a flat dose of ribavirin.

14 Nov 2005

HIV-positive patients have shorter survival periods while awaiting liver transplants

A new study on HIV-positive patients eligible for liver transplants found that their survival while waiting for a transplant is significantly shorter than patients who are HIV-negative.

7 Nov 2005

Accumulation of fat in the liver linked to hypertension

The accumulation of fat in the liver, or "fatty liver," resulting from accumulation of central body fat, and perhaps not alcohol consumption, may represent an important underlying mechanism for the association between liver enzymes and hypertension.

3 Nov 2005