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Overexpression of hPCL3S could contribute to tumor progression in prostate cancer

The cover for issue 12 of Oncotarget features Figure 11, "Global analyses of the RNA-Seq data of LNCaP empty vector and LNCaP cells overexpressing hPCL3S (Clone 12)" by Abdelfettah, et al.

25 Mar 2020

Study identifies ancestral fragments of DNA associated with hereditary prostate cancer

Vanderbilt researchers have identified haplotypes, ancestral fragments of DNA, that are associated with hereditary prostate cancer (HPC) in a first-of-its-kind genomic study made possible by the study of prostate cancer patients with family histories of the disease.

23 Mar 2020

Abnormal retinal gene function underlying vision loss in dogs

A canine study carried out at the University of Helsinki has described a gene variant in the regulatory region of the retina resulting in the abnormal function of retinal genes and, eventually, in the loss of vision in dogs.

10 Mar 2020

CRISPR-Cas system can be used to effectively target colitis pathogen

Research at North Carolina State University shows that the CRISPR-Cas system can be used to effectively target and eliminate specific gut bacteria, in this case Clostridioides difficile, the pathogen that causes colitis - a chronic, degenerative disease of the colon.

10 Mar 2020

CU research identifies ways to improve care provided to trafficked children

Newly published research by a CU School of Medicine faculty member and colleagues identifies multiple ways that health care providers and organizations can improve the quality of care provided to trafficked children.

4 Mar 2020

Coriell researchers find new genetic indicator of obesity risk

Obesity is among the most common complex diseases in the United States and has been a stubborn public health challenge for decades. Its causes are wide ranging, but genetic heritability is increasingly understood to be an influential factor in determining a person's risk for the disease.

23 Feb 2020

Poor neuronal connectivity between two brain regions may be predictive of Alzheimer's risk

Late-onset Alzheimer's disease, the one that appears after age 65, is the most common form of this neurodegenerative disease and accounts for more than 90% of cases.

12 Feb 2020

Prenatal single cell blood test for gene defects

With the current state of knowledge regarding genetic testing, non-invasive prenatal testing (NIPT) is in favor for genetic testing in unborn babies, using fragments of DNA circulating in the mother’s blood.

4 Feb 2020

Exploring the connections between hip-hop, mental health and resilience using Maino's lyrics

Born in Brooklyn, New York, the rap artist Maino (Jermaine John Colman) takes his experiences not only from growing up in the famous borough, but also the 10 long years he spent behind bars at Riker's Island Penitentiary.

30 Jan 2020

Study sheds light on how norepinephrine release influences the fear-memory formation

Researchers at RIKEN Center for Brain Science have visualized the dynamic processes involving norepinephrine that influence different types of fear-memory formation in a living mouse model.

24 Jan 2020

Researchers observe fast and slow molecular pathways that support memory function

A sustained state of vigilance will generate a different type of memory than a momentary startle, and these differences are linked to distinct signaling molecules in the brains of mice.

24 Jan 2020

CHOP-led study reveals how genetic variations can influence variety of common diseases

While subtle differences in the number of genes copied from one individual and passed down to the next can be found in many healthy people, their role in disease may be much greater than previously thought.

14 Jan 2020

New 'fishing' technique to detect thousands of proteins

A new study published today in the journal Nature Cell Biology reports the use of a novel fishing method, under microscopy, to pick up thousands of proteins that are involved in supervising how the cell skeleton is assembled.

23 Dec 2019

The brain’s temporal lobe is also an attention controlling area, shows study

As you read this line, you're bringing each word into clear view for a brief moment while blurring out the rest, perhaps even ignoring the roar of a leaf blower outside.

19 Dec 2019

Kanazawa University researchers describe genetic typing of Pseudomonas putida

Pseudomonas putida is a bacterium occuring in soil, aquatic environments and plants. Although the virulence of Pseudomonas p. -- the ability of the bacterium to infect its host and inflict a disease -- is considered to be low, infection in severely ill patients can be lethal. P. putida strains (also called isolates) have been found in hospitals, e.g. in urine, blood or wound discharge from patients, and such clinical isolates have been found to display resistance to drugs.

6 Dec 2019

Heuneburg Early Celts from all social classes may have used local ceramics to consume Mediterranean wine

Early Celts from the Heuneburg settlement may have enjoyed Mediterranean wine well before they began importing Mediterranean drinking vessels—and this special drink may have been available to all in the community, according to a study published October 23, 2019 in the open-access journal PLOS ONE by Maxime Rageot from Ludwig-Maximilians-Universität München and the University of Tübingen, and colleagues.

From PLOS ONE 18 Oct 2019

Locus News and Research

Overexpression of hPCL3S could contribute to tumor progression in prostate cancer

Study identifies ancestral fragments of DNA associated with hereditary prostate cancer

Abnormal retinal gene function underlying vision loss in dogs

CRISPR-Cas system can be used to effectively target colitis pathogen

CU research identifies ways to improve care provided to trafficked children

Coriell researchers find new genetic indicator of obesity risk

Poor neuronal connectivity between two brain regions may be predictive of Alzheimer's risk

Prenatal single cell blood test for gene defects

Exploring the connections between hip-hop, mental health and resilience using Maino's lyrics

Study sheds light on how norepinephrine release influences the fear-memory formation

Researchers observe fast and slow molecular pathways that support memory function

CHOP-led study reveals how genetic variations can influence variety of common diseases

New 'fishing' technique to detect thousands of proteins

The brain’s temporal lobe is also an attention controlling area, shows study

Kanazawa University researchers describe genetic typing of Pseudomonas putida

Heuneburg Early Celts from all social classes may have used local ceramics to consume Mediterranean wine

Study: Genetic differences in the immune system shape bacteria that colonize the digestive system

TSC1 status may predict response to Hsp90 inhibitors in bladder cancer patients

Study uncovers epigenetic origins for hypersexual disorder

Want to reduce suicides? Follow the data — to medical offices, motels and even animal shelters

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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