Lou Gehrig's Disease News and Research

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Lou Gehrig's Disease or Amyotrophic Lateral Sclerosis (ALS) is a neurological disorder characterized by progressive degeneration of motor neuron cells in the spinal cord and brain, which ultimately results in paralysis and death. The disease takes its less-scientific name from Lou Gehrig, a baseball player with the New York Yankees in the late 1920s and 1930s, who was forced to retire in 1939 as a result of the loss of motor control caused by the disease.

In 1991, a team of researchers linked familial ALS to chromosome 21. Two years later, the SOD1 gene was identified as being associated with many cases of familial ALS. The enzyme coded for by SOD1 carries out a very important function in cells: it removes dangerous superoxide radicals by converting them into non-harmful substances. Defects in the action of this enzyme mean that the superoxide radicals attack cells from the inside, causing their death. Several different mutations in this enzyme all result in ALS, making the exact molecular cause of the disease difficult to ascertain.

Recent research has suggested that treatment with drugs called antioxidants may benefit ALS patients. However, since the molecular genetics of the disease are still unclear, a significant amount of research is still required to design other promising treatments for ALS.
ALS progression linked to mitochondria-associated membrane-ER disconnection

ALS progression linked to mitochondria-associated membrane-ER disconnection

UCSF research lays the groundwork for preventing deafness

UCSF research lays the groundwork for preventing deafness

Hackensack Meridian's Dr. Mary Sedarous wins ALS United Mid-Atlantic's Flame of Hope Award

Hackensack Meridian's Dr. Mary Sedarous wins ALS United Mid-Atlantic's Flame of Hope Award

New drug shows exciting promise for the treatment of ALS

New drug shows exciting promise for the treatment of ALS

Clinical trial demonstrates the effectiveness of ALS drug in treating people with acute spinal cord injuries

Clinical trial demonstrates the effectiveness of ALS drug in treating people with acute spinal cord injuries

Ongoing gene therapy trials have driven increased use of ALS genetic testing, finds study

Ongoing gene therapy trials have driven increased use of ALS genetic testing, finds study

Ohio State University Wexner Medical Center administers first targeted gene therapy for ALS

Ohio State University Wexner Medical Center administers first targeted gene therapy for ALS

A new Medicare proposal would cover training for family caregivers

A new Medicare proposal would cover training for family caregivers

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Remote work: An underestimated benefit for family caregivers

Remote work: An underestimated benefit for family caregivers

Researchers discover a receptor and protein associated with Lou Gehrig's disease

Researchers discover a receptor and protein associated with Lou Gehrig's disease

Scientists discover how a "poisoned" form of protein could spur cancer formation

Scientists discover how a "poisoned" form of protein could spur cancer formation

USC researchers identify two promising avenues for developing new ALS treatments

USC researchers identify two promising avenues for developing new ALS treatments

Soft robotic wearable can assist ALS patients with upper arm and shoulder movement

Soft robotic wearable can assist ALS patients with upper arm and shoulder movement

Microscopic technique enables real-time study of RNA G-quadruplexes in living cells

Microscopic technique enables real-time study of RNA G-quadruplexes in living cells

Brain-computer interfaces' safety is similar to other implanted neurologic devices, study shows

Brain-computer interfaces' safety is similar to other implanted neurologic devices, study shows

Newly identified brain molecule orchestrates the immune system's responses to Alzheimer's and MS

Newly identified brain molecule orchestrates the immune system's responses to Alzheimer's and MS

USF researchers test a protein that shows potential as novel therapeutic for ALS patients

USF researchers test a protein that shows potential as novel therapeutic for ALS patients

UW joins the Alliance for Therapies in Neuroscience to transform the fight against neurological diseases

UW joins the Alliance for Therapies in Neuroscience to transform the fight against neurological diseases

Immune and central nervous systems may play a key role in ALS, Mount Sinai researchers report

Immune and central nervous systems may play a key role in ALS, Mount Sinai researchers report