Lou Gehrig's Disease News and Research

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Lou Gehrig's Disease or Amyotrophic Lateral Sclerosis (ALS) is a neurological disorder characterized by progressive degeneration of motor neuron cells in the spinal cord and brain, which ultimately results in paralysis and death. The disease takes its less-scientific name from Lou Gehrig, a baseball player with the New York Yankees in the late 1920s and 1930s, who was forced to retire in 1939 as a result of the loss of motor control caused by the disease.

In 1991, a team of researchers linked familial ALS to chromosome 21. Two years later, the SOD1 gene was identified as being associated with many cases of familial ALS. The enzyme coded for by SOD1 carries out a very important function in cells: it removes dangerous superoxide radicals by converting them into non-harmful substances. Defects in the action of this enzyme mean that the superoxide radicals attack cells from the inside, causing their death. Several different mutations in this enzyme all result in ALS, making the exact molecular cause of the disease difficult to ascertain.

Recent research has suggested that treatment with drugs called antioxidants may benefit ALS patients. However, since the molecular genetics of the disease are still unclear, a significant amount of research is still required to design other promising treatments for ALS.
Salmonella biofilm protein can cause autoimmune responses, arthritis in animals

Salmonella biofilm protein can cause autoimmune responses, arthritis in animals

Link between ALS and Alzheimer's disease can help advance the search for new therapies

Link between ALS and Alzheimer's disease can help advance the search for new therapies

UMSOM researchers identify how certain gene mutations cause ALS

UMSOM researchers identify how certain gene mutations cause ALS

Study provides groundwork for restoring nerve-muscle connection in ALS

Study provides groundwork for restoring nerve-muscle connection in ALS

Rat spinal cords control muscular behaviors in novel biohybrid robots

Rat spinal cords control muscular behaviors in novel biohybrid robots

Scientists delay onset of amyotrophic lateral sclerosis in mice

Scientists delay onset of amyotrophic lateral sclerosis in mice

Blue light illuminates key ALS pathologies in zebrafish

Blue light illuminates key ALS pathologies in zebrafish

Supplementing diet with amino acid delays signs of ALS in animal study

Supplementing diet with amino acid delays signs of ALS in animal study

Unexpected findings could lead to new therapeutic intervention for ALS

Unexpected findings could lead to new therapeutic intervention for ALS

Collaborative research uncovers underlying rules that, when broken, contribute to ALS

Collaborative research uncovers underlying rules that, when broken, contribute to ALS

AI Therapeutics reports considerable progress on LAM-001 and LAM-004 clinical trials

AI Therapeutics reports considerable progress on LAM-001 and LAM-004 clinical trials

A new kind of testing for patients with Parkinson's disease

A new kind of testing for patients with Parkinson's disease

Magnetic nano-sized disks could restore function for Lou Gehrig’s disease patients

Magnetic nano-sized disks could restore function for Lou Gehrig’s disease patients

ALS patients with commonly inherited genetic variation may experience more severe symptoms

ALS patients with commonly inherited genetic variation may experience more severe symptoms

Northwestern scientists receive $3.1 million grant to investigate drug therapies for ALS

Northwestern scientists receive $3.1 million grant to investigate drug therapies for ALS

Novel robotic neck brace could improve quality of life for ALS patients

Novel robotic neck brace could improve quality of life for ALS patients

Prion disease in mice treated successfully with antisense oligonucleotides

Prion disease in mice treated successfully with antisense oligonucleotides

Intestinal microbes may affect course of amyotrophic lateral sclerosis

Intestinal microbes may affect course of amyotrophic lateral sclerosis

Researchers explain how 'viral' agents of neurological diseases ended up in our DNA

Researchers explain how 'viral' agents of neurological diseases ended up in our DNA

Copper compound with potential as therapy for ALS shows further promise

Copper compound with potential as therapy for ALS shows further promise