Low Density Lipoprotein (LDL) News and Research

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LipoScience presents key findings related to LDL-P and CVD at AHA annual meeting

LipoScience, Inc., an in vitro diagnostic company committed to advancing patient care in cardiovascular, metabolic and other diseases, today presented key findings related to lipoprotein particles (LDL-P) and cardiovascular disease at the Annual Meeting of the American Heart Association (AHA) in Los Angeles.

7 Nov 2012

AMG 145 can reduce LDL cholesterol levels by up to 66% after 12 weeks

For many people with high cholesterol, statins serve as the first line of treatment. However, some patients are unable to effectively reduce their low-density lipoprotein cholesterol (LDL cholesterol) or "bad cholesterol" levels with statins, the most commonly used medication to treat high cholesterol, due to their bodies' inability to tolerate or sufficiently respond to the medicine.

7 Nov 2012

Monoclonal antibody boosts cholesterol reduction

Adding a monoclonal antibody that blocks the breakdown of lipid receptors to atorvastatin therapy further reduces low-density lipoprotein cholesterol levels in patients with primary hypercholesterolemia, show study findings.

6 Nov 2012

Probiotic formulation can reduce cholesterol esters

Two daily doses of a probiotic lowered key cholesterol-bearing molecules in the blood as well as "bad" and total cholesterol, in a study presented at the American Heart Association's Scientific Sessions 2012.

6 Nov 2012

Peptide-enhanced tomatoes reduce atherosclerosis in mice

For the first time, genetically engineered tomato plants produced a peptide that mimics the actions of good cholesterol when eaten, researchers reported at the American Heart Association's Scientific Sessions 2012.

6 Nov 2012

Patients with diabetes, multi-vessel coronary artery disease can benefit from bypass surgery

An international, clinical research trial has shown that patients with diabetes whose multi-vessel coronary artery disease is treated with bypass surgery live longer and are less likely to suffer severe complications like heart attacks than those who undergo angioplasty.

6 Nov 2012

Study compares effectiveness of CABG surgery with PCI for adults with diabetes and heart disease

Adults with diabetes and multi-vessel coronary heart disease who underwent cardiac bypass surgery had better overall heart-related outcomes than those who underwent an artery-opening procedure to improve blood flow to the heart muscle, according to the results from an international study. The research was supported by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health.

5 Nov 2012

Data from four Phase 2 trials of AMG 145 to be presented at AHA Scientific Sessions 2012

Amgen will present data from four Phase 2 trials of AMG 145, an investigational fully human monoclonal antibody directed against PCSK9, a protein that reduces the liver's ability to remove low density lipoprotein cholesterol, or "bad" cholesterol from the blood, at the upcoming American Heart Association Scientific Sessions 2012.

3 Nov 2012

Lomitapide shows promise in treating homozygous familial hypercholesterolemia

An international effort led by researchers at the Perelman School of Medicine at the University of Pennsylvania has resulted in positive phase 3 clinical trial results for a new medicine to treat patients suffering from a rare and deadly cholesterol disorder.

3 Nov 2012

Resistin protein causes high levels of bad cholesterol

Canadian scientists have discovered that a protein called resistin, secreted by fat tissue, causes high levels of "bad" cholesterol (low-density lipoprotein or LDL), increasing the risk of heart disease.

29 Oct 2012

Cardiovascular disease risk varies with HIV subgroup

The ability of lipids to predict risk for cardiovascular disease may be weakened in women who are infected with HIV, report researchers.

23 Oct 2012

Study finds overall decline in cholesterol levels among U.S. adults

An analysis of nationally-representative data indicates that between 1988 and 2010 there has been a trend of declining average levels of total cholesterol, non-high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol for U.S. adults overall, according to a study in the October 17 issue of JAMA.

17 Oct 2012

Intensive treatment with high doses of statin drugs shows promise for dyslipidemia

A comprehensive new review on how to treat high cholesterol and other blood lipid problems suggests that intensive treatment with high doses of statin drugs is usually the best approach.

16 Oct 2012

Study identifies 21 new gene variants associated with risks of heart disease, metabolic disorders

In the largest-ever genetic study of cholesterol and other blood lipids, an international consortium has identified 21 new gene variants associated with risks of heart disease and metabolic disorders.

12 Oct 2012

Mediterranean and low-carbohydrate diets have long-lasting healthy effects

Mediterranean and low-carbohydrate diets have lasting, healthy effects, even with partial weight regain, according to a follow-up study by researchers from Ben-Gurion University of the Negev (BGU) and Israel's Nuclear Research Center.

12 Oct 2012

Dieting, exercise can spur HDL cholesterol production in type 2 diabetics

With a little exercise and dieting, overweight people with type 2 diabetes can still train their fat cells to produce a hormone believed to spur HDL cholesterol production, report medical researchers from The Methodist Hospital and eight other institutions in an upcoming issue of the Journal of Lipid Research.

10 Oct 2012

High-fat Western diet could lead to development of atherosclerosis

Columbia University Medical Center (CUMC) researchers have found that a diet high in saturated fat raises levels of endothelial lipase (EL), an enzyme associated with the development of atherosclerosis, and, conversely, that a diet high in omega-3 polyunsaturated fat lowers levels of this enzyme.

10 Oct 2012

Estrogen/progesterone treatment started soon after menopause appears safe and effective

Estrogen/progesterone treatment started soon after menopause appears safe and relieves many of the symptoms menopausal women face as well as improving mood and markers of cardiovascular risk, according to a multicenter randomized study presented at the North American Menopause Society (NAMS) Annual Meeting in Orlando, Florida.

4 Oct 2012

Eating apples might help keep the cardiologist away

Eating an apple a day might in fact help keep the cardiologist away, new research suggests.

3 Oct 2012

Oil blend plus antihypertensive lowers blood pressure, cholesterol level

A blend of sesame and rice bran oil could reduce blood pressure by almost as much as an antihypertensive medication, say researchers.

1 Oct 2012

Low Density Lipoprotein (LDL) News and Research

LipoScience presents key findings related to LDL-P and CVD at AHA annual meeting

AMG 145 can reduce LDL cholesterol levels by up to 66% after 12 weeks

Monoclonal antibody boosts cholesterol reduction

Probiotic formulation can reduce cholesterol esters

Peptide-enhanced tomatoes reduce atherosclerosis in mice

Patients with diabetes, multi-vessel coronary artery disease can benefit from bypass surgery

Study compares effectiveness of CABG surgery with PCI for adults with diabetes and heart disease

Data from four Phase 2 trials of AMG 145 to be presented at AHA Scientific Sessions 2012

Lomitapide shows promise in treating homozygous familial hypercholesterolemia

Resistin protein causes high levels of bad cholesterol

Cardiovascular disease risk varies with HIV subgroup

Study finds overall decline in cholesterol levels among U.S. adults

Intensive treatment with high doses of statin drugs shows promise for dyslipidemia

Study identifies 21 new gene variants associated with risks of heart disease, metabolic disorders

Mediterranean and low-carbohydrate diets have long-lasting healthy effects

Dieting, exercise can spur HDL cholesterol production in type 2 diabetics

High-fat Western diet could lead to development of atherosclerosis

Estrogen/progesterone treatment started soon after menopause appears safe and effective

Eating apples might help keep the cardiologist away

Oil blend plus antihypertensive lowers blood pressure, cholesterol level

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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