Low Density Lipoprotein (LDL) News and Research

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Sibling history is a better predictor of coronary heart disease than parental history or traditional risk factor scoring

Researchers at Johns Hopkins have found that sibling history -- whether or not a brother or sister had early heart disease -- is a better predictor of a person's likelihood of developing coronary heart disease than parental history or traditional risk factor scoring.

4 Oct 2004

Hibiscus flowers contain antioxidants that help control cholesterol levels

Hibiscus flower extract may have the same health benefits as red wine and tea according to new research by scientists in Taiwan. Hibiscus contains antioxidants that help control cholesterol levels and reduce heart disease, says the research in Journal of the Science of Food and Agriculture.

14 Sep 2004

Ezetrol co-administration with statin therapy lowers LDL cholesterol in diabetics

Results from two new clinical trials show that patients with diabetes and metabolic syndrome who are treated with ezetimibe (EZETROL®) co-administered with a statin experience greater reductions in LDL (“bad”) cholesterol, compared to patients taking a statin alone.

7 Sep 2004

Early use of aggressive statin therapy may offer some benefit for coronary patients

Statins initiated early after a patient experiences an acute coronary syndrome (ACS) event at dosages above the typical starting dose may help reduce subsequent cardiovascular events, but the high dose regimen used may increase the risk for muscle-related complications, according to the results from the Phase Z portion of the A to Z Trial released on the JAMA website today.

30 Aug 2004

High blood pressure combined with elevated LDL cholesterol more than triples risk of heart attack

High blood pressure and high LDL-cholesterol add up to more than just double trouble for heart health, a Penn State College of Medicine study reports.

30 Aug 2004

Statins (HMG-CoA reductase inhibitors), are effective long term

Statins (HMG-CoA reductase inhibitors), a class of drugs that block production of cholesterol in the liver, lower total cholesterol and LDL and are also associated with cardiovascular benefits, are effective in the long term, conclude authors of a study in this week’s issue of THE LANCET.

26 Aug 2004

Early cholesterol-lowering drug therapy reduces artery-clogging plaque

Early cholesterol-lowering drug therapy after hospitalization for acute coronary syndrome appears to reduce artery-clogging plaque, according to a study reported in Circulation: Journal of the American Heart Association.

25 Aug 2004

Blueberries may lower cholesterol

New research from the U.S. Department of Agriculture shows that blueberries may lower cholesterol as effectively as a commercial drug and have the potential for fewer adverse side effects.

23 Aug 2004

Cholesterol guidelines advise more intensive treatment

Cardiologists at Temple University Hospital are working with area primary care physicians to help educate patients who are at moderate-to- high risk for heart attack about new guidelines for lowering cholesterol.

23 Aug 2004

People with type 2 diabetes could benefit from atorvastatin

Results of a randomised trial in this week’s issue of THE LANCET suggest that people with type 2 diabetes could benefit from cholesterol-lowering therapy with statins to reduce the risk of cardiovascular disease, even when they do not have high cholesterol concentrations.

20 Aug 2004

Revised cholesterol-lowering guidelines constitute a major risk to public health

Recently revised cholesterol-lowering guidelines constitute a major risk to public health according to The International Network of Cholesterol Skeptics, a non-profit organization of doctors, scientists and researchers.

18 Aug 2004

Veterans Affairs patients with diabetes are better cared for than managed care patients

Researchers have found that Veterans Affairs patients with diabetes are more likely to receive recommended tests and have better outcomes than managed care patients.

17 Aug 2004

Not all good cholesterol helps to protect arteries from becoming clogged with fatty deposits

HDL becomes dysfunctional, Dr. Hazen said, when myeloperoxidase (MPO), an enzyme present in white blood cells, inhibits the HDL's ability to keep LDL, or "bad" cholesterol, from building up in artery walls.

17 Aug 2004

Effects of oxidative stress on atherosclerosis

Heart disease and stroke are the first and third leading causes of death among men and women in the United States and account for 40 percent of all mortalities, according to the Centers for Disease Control and Prevention.

9 Aug 2004

Novel treatment of patients with high cholesterol focus of national meeting

Implications of recent lipid-lowering clinical trials and the specific changes to the NCEP guidelines will be the focus of discussion by Neil J. Stone, M.D., professor of clinical medicine of the Feinberg School of Medicine at Northwestern University.

6 Aug 2004

Approval of cholesterol-lowering therapy Lipitor for the prevention of cardiovascular disease

Pfizer has announced that the U.S. Food and Drug Administration has approved its cholesterol-lowering therapy Lipitor® (atorvastatin calcium) for the prevention of cardiovascular disease by reducing heart attack risk in people with normal to mildly elevated cholesterol levels who have other cardiovascular risk factors.

5 Aug 2004

FDA approval for VYTORIN for the treatment of high LDL cholesterol (LDL-C)

Merck/Schering-Plough Pharmaceuticals has announced that the U.S. Food and Drug Administration has approved VYTORIN™ (ezetimibe/simvastatin) for the treatment of high LDL cholesterol (LDL-C) in patients with primary hypercholesterolemia or mixed hyperlipidemia as adjunctive therapy to diet when diet alone is not enough.

26 Jul 2004