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CRISPR-scanning could lead to more effective treatments for cancer

11,000 people are predicted to die from acute myeloid leukemia in 2019, according to the American Cancer Society. The cancer starts in the bone marrow. There, mutated genes fail to prevent blood cells from replicating again and again and again, growing tumors.

16 Apr 2019

Scientists identify how cells make choice between various mechanisms to repair DNA

When DNA in the cell nucleus gets damaged, our cells can resort to a variety of repair mechanisms. A recent study published in 'Nature Cell Biology', to which scientists from Helmholtz Zentrum Muenchen made major contributions, elucidates the molecular basis by which a cell makes the choice between these repair mechanisms.

28 Feb 2019

Researchers uncover new role of heterochromatin in maintaining chromosomal integrity

Although many people are aware that chromosomal damage and shortening contribute to the aging process, understanding how chromosomal defects occur is about more than just finding a way to turn back the clock. Large changes in the structure of chromosomes, known as gross chromosomal rearrangements, can result in cell death or genetic diseases such as cancer.

24 Jan 2019

Study reveals how ASV and HIV-1 share similar structural features that drive membrane targeting, assembly

A key step in retroviral growth inside a cell, as described by Jamil Saad, Ph.D., and colleagues, is portrayed on the cover of The Journal of Biological Chemistry.

18 Dec 2018

Researchers identify powerful inhibitor of epigenetic factors that promote acute myeloid leukemia

Some severe forms of leukemia develop because proteins on the epigenetic level lose their regulative function. Now, in a broad international collaboration, UK researchers have identified molecules that can effectively inhibit the dysregulated proteins.

27 Nov 2018

Study analyzes quality of protein supplements in function of source, treatment and storage

Powdered protein supplements are one of the most commonly consumed nutritional supplements, whether by professional sportspeople or amateurs, even by those who use them for aesthetic purposes instead of sporting ones.

25 Sep 2018

Researchers describe novel mechanism that links epigenetic change to translational control

Understanding how memories form and are retrieved has applications to psychiatric, neurological and neurodegenerative disorders, and may be helpful to attenuate maladaptive memories in psychiatric disorders.

7 Sep 2018

Research uncovers new mechanism involved in bone formation

Osteoporosis is a disease that causes bones to fracture easily due to a reduction in both bone mass and quality. Aging is one of its leading causes, and it is estimated that around 200 million people are affected worldwide.

5 Sep 2018

HKBU chemists discover metal-based inhibitor to treat triple-negative breast cancer

Chemists at Hong Kong Baptist University have discovered the use of a metal compound that inhibits the enzyme closely associated with triple-negative breast cancer, one of the most difficult forms of breast cancer to treat.

30 Aug 2018

Researchers engineer peptide nanoparticles to outsmart biological system and target kidney cells

Remember the scene in the movie Mission: Impossible when Tom Cruise has to sneak into the vault? He had to do all sorts of moves to avoid detection. That's what it's like to sneak a targeted drug into a kidney and keep it from getting eliminated from the body.

22 Aug 2018

Dartmouth scientists create more sustainable feed for aquaculture

Dartmouth scientists have created a more sustainable feed for aquaculture by using a marine microalga co-product as a feed ingredient.

18 Aug 2018

Bacterial activity in child's mouth may serve as biomarkers for autism spectrum disorder

New research suggests that shifts in the bacteria within a child's mouth could provide objective biomarkers for identifying autism spectrum disorder.

17 Aug 2018

New drug delivery system delivers anticancer drugs that reduce tumor size

Cancer tissue cells are divided into two major groups: cancer cells and cancer stem cells. CSCs are related to cancer progression and dissemination, so it's necessary to eradicate CSCs in order to cure cancer.

9 Aug 2018

Researchers raise viability of cloned mice using somatic cell nuclear transfer method

An international group of researchers have raised the viability of mice that were cloned using a method called somatic cell nuclear transfer, by stimulating two epigenetic factors, and by doing this have shown that creating cloned animals more efficiently will require further work in the area of epigenetics.

20 Jul 2018

Scientists discover protein regulator of myelin production

Scientists have made an important discovery about the role of a protein called PRMT5 in the production of myelin.

19 Jul 2018

Researchers discover glutamine-dependent activation of cell growth and autophagy

The human body consists of about 35 trillion cells, so it could be said that overall body growth is the growth of individual cells.

3 May 2018

LSD1 enzyme regulates skeletal muscle differentiation and metabolic activity

Our bodies convert food into energy for all life activities. These metabolic processes allow the cells that make up our bodies to produce (anabolism) and consume (catabolism) energy molecules from nutrients.

12 Apr 2018

Study findings establish basis for epigenetic link between aging and Alzheimer's disease

Although certain genetic variants increase the risk of Alzheimer's disease (AD), age is the strongest known risk factor. But the way in which molecular processes of aging predispose people to AD, or become impaired in AD remains a mystery.

6 Mar 2018

Researchers propose new regulation mechanism linked to action of SirT6 on chromatin

Researchers from the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute, led by Dr. Àlex Vaquero, have proposed a new regulation mechanism of the NF-κB pathway, which is associated with accelerated cellular aging, based on the analysis of the function of the SirT6 protein.

19 Jan 2018

Scientists provide insights into crucial interaction for DNA repair

Osaka University scientists, in collaboration with The University of Tokyo, describe the crystal structure of RNF168 bound to ubiquitin chains, a crucial interaction for DNA repair, to find a unique interaction DNA is like the computer code of the body, and it must be preserved for our bodies to survive.

16 Jan 2018