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Researchers explore how a small change in protein shape causes long-term consequences

Sometimes proteins misfold. When that happens in the human brain, the pileup of misfolded proteins can lead to neurodegenerative diseases like Alzheimer's, Parkinson's and ALS.

19 May 2020

Technologies converge on interacting surfaces in protein complexes

Researchers have fine-tuned a method to pinpoint surfaces within interacting large multi-protein complexes.

14 Apr 2020

Tracking tau protein yields insight into possible treatments for neurodegenerative diseases

In the fight against neurodegenerative diseases such as frontotemporal dementia, Alzheimer's and Chronic Traumatic Encephalopathy, the tau protein is a major culprit.

1 Apr 2020

Researchers elucidate new mechanism for controlling DNA methylation in cells

Why normal cells turn into cancer cells One of the factors is deeply related to the failure of the cell differentiation mechanism called DNA methylation.

17 Mar 2020

Study contributes to better understanding of rare KAT6A syndrome

A research team has described five new cases of a rare disease -known as KAT6A syndrome- of which there are only eighty dominant cases worldwide.

26 Feb 2020

Study identifies novel anti-aging targets

A recent study published in Nature has reported two conserved epigenetic regulators as novel anti-aging targets.

26 Feb 2020

Turning stink into therapy for atherosclerosis

In an amusing but amazing turnaround, it seems the most foul-smelling compound on earth, called putrescine, could help relieve chronic inflammation, most importantly in the arterial thickening called atherosclerosis. This discovery is reported in the journal Cell Metabolism in January 2020.

30 Jan 2020

Study identifies previously unknown toxic by-products potentially present in drinking water

Researchers at John Hopkins University have found that the most common method for disinfecting water can generate toxic by-products.

29 Jan 2020

Jefferson researcher probes kidney cancer's genes for interactions with p53 pathway

p53 is the most famous cancer gene, not least because it's involved in causing over 50% of all cancers. When a cell loses its p53 gene -- when the gene becomes mutated -- it unleashes many processes that lead to the uncontrolled cell growth and refusal to die, which are hallmarks of cancer growth.

20 Dec 2019

Novel nanopipette pH biosensor could help with cancer diagnosis and treatment

Nanopipettes with zwitterionic membranes may offer improved monitoring of changes in pH surrounding living cells, which can indicate traits of invasive cancer cells and their response to treatment, report researchers at Kanazawa University in Nature Communications.

6 Dec 2019

Researchers make major breakthrough in cell signalling

Researchers at the University of Liverpool have made a major breakthrough in the field of cell signalling.

4 Nov 2019

Study: MIB2 improves inflammation by degrading CYLD enzyme

The tumor suppressor CYLD lysine 63 deubiquitinase (CYLD) is a deubiquitinating enzyme that suppresses polyubiquitin-dependent signaling pathways, including the proinflammatory and cell growth-promoting NF-κB pathway.

30 Oct 2019

How the SETD1A gene produces schizophrenia in mice

A new study published in the journal Neuron on October 9, 2019 reports that scientists have unlocked part of the secrets of the SETD1A gene – how mutations in the gene put the individual at risk for the condition.

26 Oct 2019

Histone modifications play important role in 'zygotic genome activation'

Scientists at Tokyo Institute of Technology observed changes to the gene-regulating factors during zebrafish development and discovered that modifications to "histone H3", one of the proteins around which DNA is bound, play an important role in "zygotic genome activation" or transition of control of zebrafish embryonic development from maternal material to the zygote .

8 Oct 2019

Researchers show how microorganisms protect themselves against free radicals

There are numerous different scenarios in which microorganisms are exposed to highly reactive molecules known as free radicals.

5 Aug 2019

Researchers reveal two metabolic pathways that may play a role in DOHaD hypothesis

The Developmental Origins of Health and Disease (DOHaD) hypothesis is supported by multiple human epidemiological studies and animal studies.

9 Jul 2019

Heart failure drug could be effective in treating leukemia

Canadian researchers followed their intuition that a drug initially intended for heart failure could be effective in treating cancer. Those efforts have borne fruit, as demonstrated by their work published in the Journal of Experimental and Clinical Cancer Research.

13 Jun 2019