Lysosomes News and Research

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Immune reaction to metals in joint replacement devices leads to early failure

Researchers at Rush University Medical Center have identified a key immunological defense reaction to the metals in joint replacement devices, leading to loosening of the components and early failure.

4 Mar 2009

New genetic clues on molecular evolution of Q fever pathogen

Scientists from the National Institute of Allergy and Infectious Diseases, Texas A&M Health Center, and the Virginia Bioinformatics Institute at Virginia Tech have uncovered genetic clues about why some strains of the pathogen Coxiella burnetii are more virulent than others.

2 Feb 2009

Researchers identify compound that frees trapped cholesterol

Researchers at UT Southwestern Medical Center have identified in mice a compound that liberates cholesterol that has inappropriately accumulated to excessive levels inside cells.

27 Jan 2009

New tools that spotlight individual cellular molecules are transforming biomedical research

Remarkable new tools that spotlight individual cellular molecules are transforming biomedical research.

27 Jan 2009

Scientists discover a compound that gets rid of excess cholesterol

New research by scientists in the United States carried out in mice has revealed a compound that releases excessive cholesterol accumulated inside cells.

27 Jan 2009

Discovery of potential important pathway for controlling cell loss and survival in Parkinson's disease

Neurologists have observed for decades that Lewy bodies, clumps of aggregated proteins inside cells, appear in the brains of patients with Parkinson's disease and other neurodegenerative diseases.

1 Jan 2009

Glowing imaging compound allows detection of viable cancer cells in mice

Researchers have developed a new type of imaging compound that allows them to visualize viable breast cancer cells that have spread to the lungs in mice.

8 Dec 2008

Fruit flies provide new insights into a brain-damaging disease mucolipidosis type IV

Johns Hopkins researchers have used fruit flies to gain new insights into a brain-damaging disorder afflicting children.

26 Nov 2008

Researchers describe how cells recycle protein waste

Garbage collectors are important for removing trash; without them waste accumulates and can quickly become a health hazard.

11 Nov 2008

Scientists confirm a molecular clipping mechanism behind stem cell development

Stem cells don't just become a part of the liver or the brain in a flash; it takes a complex molecular choreography and requires that specific genes be switched on and off at specific times.

6 Nov 2008

Proteomics provides clues to how tuberculosis thwarts the immune system

A link between the immune system and the self-cleaning system by which biological cells rid themselves of obsolete or toxic parts may one day yield new weapons in the fight against tuberculosis and other deadly infectious diseases.

6 Nov 2008

Therapies which boost the clearance of faulty proteins in cells may slow down ageing

Scientists say as people age, their cells become less efficient at getting rid of damaged protein and the result is a buildup of toxic material; this is particularly apparent in Alzheimer's, Parkinson's disease and other neurodegenerative disorders associated with ageing.

11 Aug 2008

Scientists stop age-related decline in an entire organ

As people age, their cells become less efficient at getting rid of damaged protein - resulting in a buildup of toxic material that is especially pronounced in Alzheimer's, Parkinson's disease, and other neurodegenerative disorders.

10 Aug 2008

Discovery of new function for an old enzyme in sialidosis

The lack of a single protein usually thought of as a run-of-the-mill enzyme that helps to recycle molecules in cells causes an incurable and often fatal disease of children, according to St. Jude Children's Research Hospital investigators.

7 Jul 2008

Autophagy promotes pancreatitis

To survive tough times, cells sometimes resort to a form of self-cannibalism called autophagy. But as Hashimoto et al. reveal, autophagy can have a down side, destroying the pancreas by prematurely activating a digestive enzyme.

30 Jun 2008

Naglazyme approved in Japan

BioMarin Pharmaceutical Inc. has announced that AnGes MG, Inc. (AnGes), BioMarin's marketing and distribution partner in Japan, has received approval for its Marketing Application for Naglazyme(R) (galsulfase) from the Japanese Ministry of Health, Labour and Welfare (MHLW) for the treatment of patients with Mucopolysaccharidosis VI ( MPS VI).

1 Apr 2008

Scientists identify key protein in cell's 'self-eating' function

Molecular biologists at the University of California, San Diego have found one piece of the complex puzzle of autophagy, the process of "self-eating" performed by all eukaryotic cells - cells with a nucleus - to keep themselves healthy.

12 Mar 2008

New hope for Batten disease sufferers

Investigators at the University of Rochester Medical Center have uncovered a promising drug therapy that offers a ray of hope for children with Batten disease – a rare neurodegenerative disease that strikes seemingly healthy kids, progressively robs them of their abilities to see, reason and move, and ultimately kills them in their young twenties.

3 Jan 2008

New clue found to the cause of Parkinson's disease

A glitch in the mechanism by which cells recycle damaged components may trigger Parkinson's disease, according to a study by scientists at the Albert Einstein College of Medicine of Yeshiva University.

3 Jan 2008

New ray of hope for children with Batten disease

Investigators at the University of Rochester Medical Center have uncovered a promising drug therapy that offers a ray of hope for children with Batten disease

13 Dec 2007