MALDI TOF News and Research

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Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is a soft ionization method used in the detection of various chemical compounds with a broad mass range. MALDI-TOF can be applied in biology to the study of nucleic acids and proteins.

Muscles in microgravity: Spaceflight duration impacts muscle protein stress markers

Study explores the differential effects of short and long-duration space missions on muscle protein nitrosylation in astronauts, indicating adaptations and potential impairments in muscle function due to microgravity, and highlights the role of inflight exercise in mitigating some negative effects on muscle health.

3 Apr 2024

New algorithm proves to be a powerful tool for detection and identification of novel bacterial organisms

Researchers developed the NOVA algorithm to systematically analyze bacterial isolates unidentified using traditional methods such as matrix-assisted laser desorption ionization-time of flight mass spectrometry and partial 16S rRNA gene sequencing using whole genome sequencing.

10 Jan 2024

First study to report isolation of M. saskatchewanense from medical devices

Researchers reported the first isolation of M. saskatchewanense from medical-grade equipment.

12 Dec 2023

Researchers develop new rapid and reliable method for SARS-CoV-2 detection

Commercially available mass spectrometers can reliably detect the SARS-CoV-2 coronavirus. In the journal "Clinical proteomics" researchers from the Martin Luther University Halle-Wittenberg (MLU) present a new method which employs equipment that is already being used in hospitals and laboratories to detect bacterial and fungal infections.

16 Aug 2023

Food preservative nisin: A gut game changer that safely alters microbiome composition

Nisin, a powerful bacteriocin, influences the gut microbiota and its functionality by modulating the abundance of specific bacterial groups and altering short-chain fatty acid synthesis.

18 May 2023

Study indicates that the planetary health diet increases probiotic-associated bacteria in the gut microbiome

Researchers analyzed whole-genome data from fecal samples of healthy volunteers following three diets

18 Apr 2023

A highly efficient platform for detection of SARS-CoV-2 variants

The recent outbreak of the coronavirus disease 2019 (COVID-19) pandemic and the continuous evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have highlighted the significance of new detection methods for global monitoring and prevention.

17 Apr 2023

Study details bacterial agents in 418 ticks extracted from humans in France

In a recent study published in the journal Emerging Infectious Diseases, researchers analyzed ticks that bit humans between January 2014 and March 2021 in France for the presence of bacterial pathogens.

27 Mar 2023

Case report on Nocardia pseudobrasiliensis and SARS-CoV-2 concomitant infection

In a recent case report published in the U.S. Centers for Disease Control and Prevention’s (CDC) journal Emerging Infectious Diseases, researchers reported a case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Nocardia pseudobrasiliensis concomitant infection.

27 Mar 2023

Demographic, geographic, and temporal variables associated with C. auris cases in Italy

A recent study reported growing cases of Candida auris in North Italy.

27 Mar 2023

High-resolution mass spectrometric rapid identification of Candida auris

A recent study published in the Journal of Fungi used a novel OrbitrapTM high-resolution mass spectrometric technology coupled with liquid chromatography to identify geographically different clades of Candida auris (C. auris) isolates. This proof-of-concept methodology could accurately detect C. auris in the microbiology laboratory.

23 Mar 2023

Shimadzu opens the door to biomolecular imaging for all with new compact MALDI-TOF imaging solution

Shimadzu Corporation announces the release of the world’s smallest MALDI-TOF imaging solution

From Shimadzu Scientific Instruments 9 Feb 2023

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.

27 Jan 2023

Study can provide deeper insight into the link between common oral bacteria and other diseases

Researchers at Karolinska Institutet in Sweden have identified the bacteria most commonly found in severe oral infections. Few such studies have been done before, and the team now hopes that the study can provide deeper insight into the association between oral bacteria and other diseases. The study is published in Microbiology Spectrum.

24 Nov 2022

Increase in Candida auris infections among EU/EEA nations between 2020 and 2021

Researchers evaluated the trends in Candida auris infections among European Union/European Economic Area (EU/EUA) nations between 2020 and 2021.

21 Nov 2022

What is the prevalence of carbapenem-resistant Enterobacterales among individuals with and without health risk factors?

Researchers assessed carbapenem-resistant Enterobacterales (CRE) epidemiology across eight US metropolitan areas between 1 January 2012 and 31 December 2015.

3 Aug 2022

Robust and highly multiplexed assay for identification of SARS-CoV-2 variants

Researchers compared the performance of a highly multiplexed mass spectrometry-based commercial assay to identify SARS-CoV-2 variants.

31 May 2022

Antimicrobial resistance in COVID-19

Researchers discuss the impact of this extensive use of antibiotics on the rise of antimicrobial resistance.

16 Mar 2022

Using AI to detect antibiotic resistance

In this interview, we speak to Professor Karsten Borgwardt and Professor Adrian Egli about their latest research that used AI to predict antibiotic resistance.

1 Mar 2022

Eating before saliva collection may interfere with detection of SARS-CoV-2

A new study, published on the medRxiv* preprint server, has aimed to determine if children's diet impacts the detection of SARS-CoV-2 virus in saliva. Scientists performed diagnostic tests to detect this virus using real-time self-collected specimens provided by five healthy children. The samples were collected before and after eating selected foods. The specific time of collection of samples after eating were 0 minutes, 20 minutes, and 60 minutes after eating.

15 Dec 2021

MALDI TOF News and Research

Further Reading

Muscles in microgravity: Spaceflight duration impacts muscle protein stress markers

New algorithm proves to be a powerful tool for detection and identification of novel bacterial organisms

First study to report isolation of M. saskatchewanense from medical devices

Researchers develop new rapid and reliable method for SARS-CoV-2 detection

Food preservative nisin: A gut game changer that safely alters microbiome composition

Study indicates that the planetary health diet increases probiotic-associated bacteria in the gut microbiome

A highly efficient platform for detection of SARS-CoV-2 variants

Study details bacterial agents in 418 ticks extracted from humans in France

Case report on Nocardia pseudobrasiliensis and SARS-CoV-2 concomitant infection

Demographic, geographic, and temporal variables associated with C. auris cases in Italy

High-resolution mass spectrometric rapid identification of Candida auris

Shimadzu opens the door to biomolecular imaging for all with new compact MALDI-TOF imaging solution

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

Study can provide deeper insight into the link between common oral bacteria and other diseases

Increase in Candida auris infections among EU/EEA nations between 2020 and 2021

What is the prevalence of carbapenem-resistant Enterobacterales among individuals with and without health risk factors?

Robust and highly multiplexed assay for identification of SARS-CoV-2 variants

Antimicrobial resistance in COVID-19

Using AI to detect antibiotic resistance

Eating before saliva collection may interfere with detection of SARS-CoV-2

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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