Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Researchers plan to target immune cells responsible for eluding antiretroviral treatment

Certain human immune cells known as macrophages are composed of hybrid HIV strains that elude treatment and antiretroviral drugs, according to a new study by researchers from the University of Florida and other institutions, the Gainesville Sun reports.

31 May 2009

New cellular targets for HIV drug development

Focusing HIV drug development on immune cells called macrophages instead of traditionally targeted T cells could bring us closer to eradicating the disease, according to new research from University of Florida and five other institutions.

27 May 2009

Salmonella’s weakness for sugar predicts its downfall

For the first time UK scientists have shown what the food poisoning bug Salmonella feeds on to survive as it causes infection: glucose.

19 May 2009

Drugs designed to tackle endoplasmic reticulum stress might be useful in treating heart disease

Researchers say they have evidence to explain what separates your average blood vessel plaque from those that are at high risk for triggering the development of dangerous - even fatal - blood clots.

5 May 2009

New light shed on salt-sensitive hypertension

A high salt intake has been implicated in cardiovascular disease risk for 5000 years. But salt-sensitive hypertension still remains an enigma.

4 May 2009

Oral delivery system for RNAi therapeutics

Researchers at the University of Massachusetts Medical School (UMMS) report on a novel approach to the delivery of small bits of genetic material in order to silence genes using "RNA interference"-and in the process, discovered a potent method of suppressing inflammation in mice similar to what occurs in a range of human diseases.

30 Apr 2009

Senior men more likely than women to die after pneumonia

Differing biological response to infection between men and women may explain higher death rates among older men who are hospitalized with community-acquired pneumonia (CAP).

29 Apr 2009

New study overturns orthodoxy on how macrophages kill bacteria

For decades, microbiologists assumed that macrophages, immune cells that can engulf and poison bacteria and other pathogens, killed microbes by damaging their DNA.

27 Apr 2009

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

Peregrine Pharmaceuticals, Inc. has reported that two preclinical studies presented during the AACR 100th Annual Meeting 2009 provided further confirmation of the immunomodulatory mechanisms contributing to the anti-tumor activity of its phosphatidylserine (PS) targeting antibodies.

22 Apr 2009

New insights into transcription factors in human cells

Bioinformatics researchers from UC San Diego just moved closer to unlocking the mystery of how human cells switch from "proliferation mode" to "specialization mode."

20 Apr 2009

Novel method of isolating high quality RNA from Kupffer cells

Kupffer cells, resident tissue macrophages that line the liver sinusoids, play a key role in modulating inflammation in a number of experimental models of liver injury.

20 Apr 2009

Inflammatory chemokine may explain diseases that come with obesity

An inflammatory factor already linked to several diseases, including pulmonary disease, lung cancer, and arthritis, may also be responsible for the insulin resistance that comes with obesity, according to a new study published in the April issue of Cell Metabolism.

8 Apr 2009

Monoclonal antibody cancer therapy

The strategy of using monoclonal antibodies for cancer treatment was first described in the late 1970s with the promise that they could be developed into therapies that were highly specific to cancer cells, killing them with few or no side effects.

6 Apr 2009

New marker for breast cancer metastasis

Researchers at NewYork-Presbyterian Hospital/Weill Cornell Medical Center have identified a new marker for breast cancer metastasis called TMEM, for Tumor Microenvironment of Metastasis.

30 Mar 2009

New test for breast cancer metastasis

Scientists at Albert Einstein College of Medicine of Yeshiva University have previously shown that the co-mingling of three cell types can predict whether localized breast cancer will spread throughout the body.

24 Mar 2009

Coenzyme rare to bacteria critical to Mycobacterium tuberculosis survival

Coenzyme F420, a small molecule that helps certain enzymes transfer electrons, is found in microorganisms known as methane-producing archaea, some of which thrive in extreme environments.

23 Mar 2009

Immune-based therapy approved in Europe for pediatric cancer patients

The European Commission, which oversees legislation and regulation for the European Union, has approved a therapy for pediatric patients with non-metastatic, resectable osteosarcoma, a type of bone cancer.

11 Mar 2009

Challenge of a cure for HIV infection

A group including leading academic and industry scientists has issued a challenge to researchers in the field of HIV/AIDS: find a way to effectively purge latent HIV infection and eliminate the need for chronic, suppressive therapy to control this disease.

5 Mar 2009

Immune reaction to metals in joint replacement devices leads to early failure

Researchers at Rush University Medical Center have identified a key immunological defense reaction to the metals in joint replacement devices, leading to loosening of the components and early failure.

4 Mar 2009

The obesity paradox

It's called the obesity paradox. Although obese people are more apt to suffer from inflammatory diseases, such as diabetes, heart disease, and stroke, they are also more likely to survive a major attack caused by one of those conditions.

26 Feb 2009