Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Exploring the versatile roles of tissue macrophages beyond immune defense

The role of resident tissue macrophages (RTMs) in homeostasis and disease.

17 Apr 2024

Vaccines targeting chronic diseases show promise in combatting age-related conditions

Vaccine-based therapeutics for age-related disorders.

17 Apr 2024

Ketamine's rapid impact on depression linked to immune system pathways

Study reveals ketamine's potent anti-inflammatory effects on neurological disorders, showing promise for treating major depressive disorder through modulation of neuroimmune pathways.

15 Apr 2024

Study reveals how SARS-CoV-2 hijacks lung cells to drive COVID-19 severity

Researchers identified how SARS-CoV-2 targets and manipulates specific lung cells, using innovative techniques to trace the virus's impact on the cells' gene expression, revealing insights into early COVID-19 pathogenesis.

14 Apr 2024

Restoring insulin sensitivity without TZD side effects

Thiazolidinediones (TZDs) are a class of drug that can be used to treat type 2 diabetes by reversing insulin resistance, one of the main hallmarks of the disease.

13 Apr 2024

Study unlocks how cortisone activates the body’s natural “brakes” on inflammation

Cortisone and other related glucocorticoids are extremely effective at curbing excessive immune reactions.

10 Apr 2024

Study reveals unexpected vulnerability of lung immune cells to SARS-CoV-2

The lung-cell type that's most susceptible to infection by SARS-CoV-2, the virus that causes COVID-19, is not the one previously assumed to be most vulnerable.

10 Apr 2024

Periostin may be a novel therapeutic target for treating esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) accounts for around 90% of esophageal cancers, especially in East Asia.

9 Apr 2024

Interferon-beta deficiency alters brain response in neuroHIV mouse model

NeuroHIV refers to the effects of HIV infection on the brain or central nervous system and, to some extent, the spinal cord and peripheral nervous system.

4 Apr 2024

Statins show promise in reducing gum disease inflammation

Could taking statins benefit your mouth in addition to your arteries? A new study conducted in cell cultures showed that cholesterol-lowering drugs help to dampen the inflammation associated with periodontal disease by altering the behavior of macrophages, a type of immune cell.

25 Mar 2024

Heart at risk from ARDS: Inflammatory responses fuel cardiovascular complications

Research highlights the inflammatory impacts of ARDS on the heart, underscoring the role of immune responses in cardiovascular complications from viral infections, including COVID-19, and emphasizes the potential of TNF-α neutralizing therapy to mitigate these effects.

24 Mar 2024

Scientists shed light on key immune regulators involved in Alzheimer’s and other disorders of lipid-rich tissues

Using novel genetic and genomic tools, researchers at the Icahn School of Medicine at Mount Sinai have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer's and other diseases.

21 Mar 2024

SARS-CoV-2-associated ARDS can damage the heart without direct infection

SARS-CoV-2, the virus that causes COVID-19, can damage the heart even without directly infecting the heart tissue, a National Institutes of Health-supported study has found.

20 Mar 2024

Groundbreaking study unveils sex-specific genetic influences on blood pressure

Genetic heterogeneity of blood pressure (BP) effects between sexes.

12 Mar 2024

Schisanhenol suppresses cytokine storm and acute lung injury in mice

Cytokine storm (CS) is an acute systemic inflammatory response with limited effective interventions up to now.

6 Mar 2024

Research uncovers key therapeutic target for reversing accelerated atherosclerosis in diabetes

Diabetes accelerates the development of atherosclerosis, increasing the incidence of cardiovascular events.

29 Feb 2024

Study finds metabolic checkpoint PHGDH as potential target to modulate tumor-associated macrophages

A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in the top-class journal Cellular & Molecular Immunology, has a promising result from tumor research: The enzyme phosphoglycerate dehydrogenase (PHDGH) acts as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs) and thus on tumor growth.

27 Feb 2024

Macrophage News and Research

Further Reading

Exploring the versatile roles of tissue macrophages beyond immune defense

Vaccines targeting chronic diseases show promise in combatting age-related conditions

Ketamine's rapid impact on depression linked to immune system pathways

Study reveals how SARS-CoV-2 hijacks lung cells to drive COVID-19 severity

Restoring insulin sensitivity without TZD side effects

Study unlocks how cortisone activates the body’s natural “brakes” on inflammation

Study reveals unexpected vulnerability of lung immune cells to SARS-CoV-2

Periostin may be a novel therapeutic target for treating esophageal squamous cell carcinoma

Interferon-beta deficiency alters brain response in neuroHIV mouse model

Statins show promise in reducing gum disease inflammation

Heart at risk from ARDS: Inflammatory responses fuel cardiovascular complications

Scientists shed light on key immune regulators involved in Alzheimer’s and other disorders of lipid-rich tissues

SARS-CoV-2-associated ARDS can damage the heart without direct infection

Groundbreaking study unveils sex-specific genetic influences on blood pressure

Schisanhenol suppresses cytokine storm and acute lung injury in mice

Research uncovers key therapeutic target for reversing accelerated atherosclerosis in diabetes

Study finds metabolic checkpoint PHGDH as potential target to modulate tumor-associated macrophages

Dietary protein overload linked to increased atherosclerosis risk

A high-protein diet and elevation in the amino acid leucine may contribute to buildup of plaque in arteries

Husker research duo selected as Phase 1 winners in the NIH's Targeted Genome Editor Delivery Challenge

Microbiology eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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