Macropinocytosis News and Research

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New drug combo shows promise in targeting RAS-mutant multiple myeloma

The combination of a drug and a protein fragment prevents the growth of blood cancer cells, a new study in mice shows.

11 Dec 2023

Discovery of a novel therapeutic target for pancreatic cancer

A novel amino acid transporter-based therapeutic target for pancreatic ductal adenocarcinoma (PDAC).

10 Oct 2023

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

With a survival rate in the single digits, pancreatic ductal adenocarcinoma (PDAC) is highly lethal. In fact, by the time PDAC is clinically diagnosed, it is already considered incurable via surgery or other means in up to 90% of patients.

2 Aug 2023

Researchers discover the Nrf3-mediated mechanism of melanogenesis

The skin is presumably the largest and one of the most versatile body organs. By providing a physical barrier, it protects our body from environmental assaults.

11 Jan 2023

Targeting macropinocytosis may be an effective therapeutic approach for hepatocellular carcinoma

Researchers from the Department of Pathology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong (HKUMed) have identified a new metabolic mechanism in liver cancer cells, by which macropinocytosis, an endocytic process, is used to engulf extracellular proteins as fuels to support the unlimited growth of hepatocellular carcinoma (HCC) in hypoxia (oxygen deprivation).

14 Jun 2022

New FR-targeting, micropinocytosis-mediated bioconjugate attacks K-Ras mutant pancreatic cancer

Often undetected until it has progressed to an advanced stage, pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer.

6 Jun 2022

Research points towards macropinocytosis as a target for future cancer treatment

It is the membrane of cancer cells that is at the focus of the new research now showing a completely new way in which cancer cells can repair the damage that can otherwise kill them.

2 Jul 2021

Pancreatic cancer cells use adaptive mechanisms to avoid death by starvation

In new findings published online March 18, 2021 in the journal Cancer Cell, an international team of researchers, led by scientists at University of California San Diego School of Medicine and Moores Cancer Center, describe how pancreatic cancer cells use an alternative method to find necessary nutrients, defying current therapies, to help them grow and spread.

19 Mar 2021

SARS-CoV-2-induced innate immune responses may vary with disease severity, finds study

Scientists from Germany and China recently conducted a large meta-analysis using transcriptome data of SARS-CoV-2 to evaluate the routes of viral entry and the characteristics of innate immune responses induced by SARS-CoV-2 infection.

11 Jan 2021

Neuropilin-1: A new route of SARS-CoV-2 entry

A new study published in the reputed journal Science in October 2020 reports the potential therapeutic value of the second type of host transmembrane receptor, called neuropilins, which attach to the spike protein of SARS-CoV-2 and may enhance its infectivity.

25 Oct 2020

A new, promising method for developing drugs that target, block macropinocytosis

With drug resistance a major challenge in the fight against cancer, a discovery by University of California, Irvine biologists could offer new approaches to overcoming the obstacle.

3 Mar 2020

Researchers discover important role for macropinocytosis in mammalian cell growth

For the first time, researchers at Michigan Medicine have demonstrated that a cellular process known to be involved in cancer and other diseases also plays an important role in the growth of at least one type of normal mammalian cell.

10 Jan 2020

Catastrophic macropinocytosis may aid in cancer treatment

In laboratory experiments, a metabolic inhibitor was able to kill a variety of human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route -- catastrophic macropinocytosis.

18 Dec 2019

Study reveals mechanism that helps pancreatic cancer cells avoid starvation

A new study reveals the mechanism that helps pancreatic cancer cells avoid starvation within dense tumors by hijacking a process that pulls nutrients in from their surroundings.

11 Dec 2019

Researchers discover new hybrid molecules that could act as anti-cancer agents

Researchers from NYU Abu Dhabi's chemistry program and colleagues from the University's biology program have developed and studied the biological activity of five new, metal-organic hybrid knotted molecules, termed metal-organic trefoil knots.

23 May 2019

Researchers unravel biomechanics of Ebola virus-host cell adhesion

It was recently reported that the number of Ebola cases in the Democratic Republic of Congo has surpassed 1,000, making it the second-worst outbreak in history after the 2014 outbreak in West Africa in which 29,000 people were infected and more than 11,000 died.

27 Mar 2019

Macropinocytosis News and Research

New drug combo shows promise in targeting RAS-mutant multiple myeloma

Discovery of a novel therapeutic target for pancreatic cancer

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

Researchers discover the Nrf3-mediated mechanism of melanogenesis

Targeting macropinocytosis may be an effective therapeutic approach for hepatocellular carcinoma

New FR-targeting, micropinocytosis-mediated bioconjugate attacks K-Ras mutant pancreatic cancer

Research points towards macropinocytosis as a target for future cancer treatment

Pancreatic cancer cells use adaptive mechanisms to avoid death by starvation

SARS-CoV-2-induced innate immune responses may vary with disease severity, finds study

Neuropilin-1: A new route of SARS-CoV-2 entry

A new, promising method for developing drugs that target, block macropinocytosis

Researchers discover important role for macropinocytosis in mammalian cell growth

Catastrophic macropinocytosis may aid in cancer treatment

Study reveals mechanism that helps pancreatic cancer cells avoid starvation

Researchers discover new hybrid molecules that could act as anti-cancer agents

Researchers unravel biomechanics of Ebola virus-host cell adhesion

Scientists solve another piece of Ebola virus puzzle

Researchers find how NF2 gene mutations lead to out-of-control cellular proliferation

Study reveals cellular pathway used by Ebola virus to enter cells

Scientists uncover surprising molecular link in critical cellular growth pathway

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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