Mammalian Cells News and Research

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In vivo, in vitro, in silico

Prof. Jens Reich, Biomathematician and member of the German National Ethics Council, is one of the scientists within the Systems Biology competence network HepatoSys who is on the scent of a major mystery of life.

17 May 2006

New Hybrid virus may aid treatment of cancer

Researchers at The University of Texas M. D. Anderson Cancer Center have created a new class of hybrid virus and demonstrated its ability to find, highlight, and deliver genes to tumors in mice.

26 Apr 2006

Important new global mechanism for gene repression

Most of the time in most cells of the body, the great majority of genes are silenced, locked away within the compacted but orderly material that makes up chromosomes.

18 Apr 2006

Whole genome analysis of the protein kinases from Dictyostelium

The journal PLoS Genetics has published the findings of a team of scientists at the nonprofit Boston Biomedical Research Institute that provides a whole genome analysis of the protein kinases from a scientifically valuable model organism known as Dictyostelium.

10 Apr 2006

Proteomics yields new drug targets for treating cardiogenic shock

When it comes to cell signaling and bioregulation, it's tough to find a more important molecule than nitric oxide (NO). Dysfunction of NO-mediated signaling is thought to be a culprit in lethal cardiovascular conditions such as angina, and septic, cardiogenic and hemorrhagic shock; it may play a role in many other illnesses as well.

3 Apr 2006

Tobacco plants being used to produce human albumin

Human serum albumin (HSA) is the intravenous protein most commonly used in the world for therapeutic ends. It is employed to stabilise blood volume and to avoid risk of a heart attack, its administration in operating theatres being almost a daily occurrence.

27 Mar 2006

Oddly shaped DNA can cause DNA breaks in mammalian cells

When otherwise normal DNA adopts an unusual shape called Z-DNA, it can lead to the kind of genetic instability associated with cancers such as leukemia and lymphoma, according to a study by researchers at The University of Texas M. D. Anderson Cancer Center.

21 Feb 2006

Intracellular observation of RNA metabolism will help identify disease-associated RNAs

For the first time, researchers can now peer inside intact cells to not only identify RNA-binding proteins, but also observe-in real-time-the intricate activities of these special molecules that make them key players in managing some of the cell's most basic functions.

7 Feb 2006

Morphotek issued patent covering the use of chemical inhibitors of mismatch repair

Morphotek Inc. announced today the issuance of United States Patent 6,982,169 covering the use of chemical inhibitors to enhance evolution of target host cell genomes by reversibly regulating mismatch repair (MMR) in vivo.

23 Jan 2006

New understanding of Mediterranean spotted fever

New research by a team of scientists in France and the United States has identified both the bacterial and host receptor proteins that enable Rickettsia conorii, the Mediterranean spotted fever pathogen, to enter cells.

15 Dec 2005

Study suggests a way to eliminate glioblastoma

Scientists have devised a strategy to treat tumors by selectively targeting and killing the malignant cells. A new preclinical study, published in the open access journal PLoS Medicine, has applied the approach to combat glioblastoma multiforme (GBM).

7 Dec 2005

Functional amyloid formation within mammalian tissue

What do neurodegenerative diseases and suntans have in common? Scientists at the Scripps Research Institute have found an intriguing molecular connection.

7 Dec 2005

New anthrax antibody

A new anthrax antibody engineered by scientists at The University of Texas at Austin protects and defends against inhalation anthrax without the use of antibiotics and other more expensive antibodies.

2 Dec 2005

Nerve-cell dendrites splice messenger RNA

Researchers at the University of Pennsylvania School of Medicine have discovered that nerve-cell dendrites have the capacity to splice messenger RNA (pre-mRNA), a process once believed to only take place in the nucleus of cells.

14 Nov 2005

St. John's wort plant has the capacity to inhibit expression of the HIV-1 gene

A novel protein, p27SJ, extracted from a callus culture of the St. John's wort plant (Hypericum perforatum) suppresses HIV-1 expression and inhibits its replication, according to researchers at Temple University School of Medicine's department of neuroscience and Center for Neurovirology (CNV).

24 Oct 2005

Researchers find gene that is important for the control of fundamental rhythms in nematode worms

University of Utah biologists found a gene that controls rhythmic events in a worm's life: swallowing food, laying eggs and pooping.

9 Oct 2005

Cells have developed a surprising transportation system for their endosomes

...according to research published today in Physical Review Letters, "Dynamics and Spatial Organization of Endosomes in Mammalian Cells."

5 Oct 2005

New method to measure circadian cycles

Everyone knows morning people and late-night owls. The variation in individual circadian rhythms is an anecdotal as well as experimentally verified fact. But, until now, to systematically study circadian differences (and thereby hope to rout out the underlying genetic causes), scientists have had to rely on prolonged behavioural observation.

27 Sep 2005

Scientists demonstrate power of new generalized screen to find function of noncoding RNAs

A team of investigators at The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation (GNF) have discovered a way to screen hundreds and potentially thousands of "noncoding" RNA molecules to discover their functions within cells.

1 Sep 2005