Mania News and Research

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Anxiety linked to symptom severity in bipolar disorder

Anxiety is common in bipolar disorder patients experiencing an episode of acute mania and is associated with increased mood symptom severity, research shows.

23 Oct 2012

Family functioning linked to disease course in adolescent BD

Family cohesion, adaptability, and conflict are associated with disease course in adolescent patients with bipolar disorder, US researchers report.

23 Oct 2012

MDD with subthreshold hypomania ‘should be merged with bipolar II’

Patients with major depressive disorder plus subthreshold hypomania exhibit significant differences in disease course, symptoms, treatment-seeking rates, and other characteristics compared with those with major depression alone, research shows.

11 Oct 2012

MDD with subthreshold hypomania ‘should be merged with bipolar II’

Patients with major depressive disorder plus subthreshold hypomania exhibit significant differences in disease course, symptoms, treatment-seeking rates and other characteristics compared with those with major depression alone, research shows.

10 Oct 2012

Kynurenic acid levels increased in bipolar patients with psychotic features

Bipolar disorder patients with a history of psychotic features have higher cerebrospinal fluid concentrations of kynurenic acid (KYNA) than those without such features, research shows.

9 Oct 2012

BD family history risk factor for recurrent episodes in MDD

A family history of bipolar disorder increases the likelihood of recurrent episodes of hypomania or mania in individuals with prior major depressive disorder, suggest findings published in Bipolar Disorders.

1 Oct 2012

Suicide attempts common in bipolar disorder inpatients

Results from a Norwegian study show that the prevalence of attempted suicide is high among inpatients with bipolar disorder, with nearly half of patients having attempted to take their own lives at least once.

25 Sep 2012

Early warning signs detected by half of BD patients

Almost half of patients with bipolar disorder are able to recognize early warning signs of a mood episode, Australian researchers report.

20 Sep 2012

Teen BD patients show specific gray matter deficits

Results from a US study show that adolescents with bipolar I disorder who have experienced their first episode of mania have gray matter deficits in the left subgenual cingulate cortex.

18 Sep 2012

Early warning signs detected by half of BD patients

Almost half of patients with bipolar disorder are able to recognize early warning signs of a mood episode, Australian researchers report.

14 Sep 2012

Stigma impacts functioning in bipolar disorder

Higher levels of perceived stigma are associated with poorer functioning in patients with bipolar disorder, research shows.

13 Sep 2012

BD I patients at high risk for sleep apnea

Around half of overweight patients with bipolar I disorder are at high risk for developing obstructive sleep apnea, US study results suggest.

5 Sep 2012

Study shows how NCAN gene results in manic symptoms of bipolar disorder

Flying high, or down in the dumps - individuals suffering from bipolar disorder alternate between depressive and manic episodes. Researchers from the University of Bonn and the Central Institute of Mental Health in Mannheim have now discovered, based on patient data and animal models, how the NCAN gene results in the manic symptoms of bipolar disorder. The results have been published in the current issue of "The American Journal of Psychiatry."

1 Sep 2012

Subsyndromal symptoms hasten relapse in BD

The presence of subsyndromal affective symptoms is associated with a significantly shorter time to relapse among euthymic patients with bipolar disorder, Spanish research shows.

31 Aug 2012

Elan commences ELND005 Phase 2 study in Bipolar I Disorder

Transition Therapeutics Inc. today announced that its licensing partner, Elan Corporation, plc has commenced a Phase 2, placebo-controlled, safety and efficacy study of oral ELND005 as an adjunctive maintenance treatment in patients with Bipolar I Disorder (BPD 1) to delay the time to occurrence of mood episodes.

31 Aug 2012

Non-right-handedness increased in BD patients

Patients with bipolar disorder are around twice as likely to be non-right-handed as mentally healthy individuals, study results show.

30 Aug 2012

Elan commences ELND005 Phase 2 study in Bipolar I Disorder

Elan Corporation, plc today announced that it has commenced a Phase 2, placebo-controlled, safety and efficacy study of oral ELND005 as an adjunctive maintenance treatment in patients with Bipolar I Disorder (BPD 1) to delay the time to occurrence of mood episodes.

30 Aug 2012

DUP may differentiate schizoaffective disorder from BD

Among individuals with a first episode of psychotic mania (FEPM), a longer duration of untreated psychosis may differentiate patients with schizoaffective disorder from those with bipolar I disorder, study results suggest.

29 Aug 2012

Study provides new direction for research in bipolar disorder during pregnancy

The impact of bipolar disorder during pregnancy has been hotly contended among the research community. Now, a new study from Lawson Health Research Institute and Western University is sorting out the debate and calling for more targeted, prospective research.

23 Aug 2012