Mast Cell News and Research

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Mount Sinai launches new center for complex chronic illnesses

Mount Sinai's Department of Rehabilitation and Human Performance has announced the grand opening of the Cohen Center for Recovery From Complex Chronic Illnesses (CoRE), providing clinical care for patients with conditions such as long Lyme disease/Lyme+, long COVID, and other infection-associated complex chronic illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Ehlers-Danlos syndrome (EDS).

10 Oct 2024

How viral persistence and immune dysfunction drive long COVID

Study explores the biological drivers and mechanisms of long COVID, shedding light on its epidemiology and potential therapeutic interventions. It emphasizes the role of viral persistence, immune dysfunction, and coagulation in the development of this condition.

29 Sep 2024

Perceived stress can directly trigger psoriasis relapse

Innovative research has provided compelling evidence that perceived stress can directly trigger the relapse of psoriatic skin lesions. The study, presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2024, is the first to scientifically validate this connection in vivo.

26 Sep 2024

Mast cells found to capture and employ neutrophils during allergic reactions

Known for their role in allergic reactions, mast cells have long been recognised as key players in our immune system.

2 Aug 2024

Neurodivergent children face higher risk of chronic disabling fatigue by 18, study finds

Neurodivergent traits in childhood double the risk of chronic disabling fatigue by age 18, with inflammation playing a significant mediating role. This highlights the importance of addressing inflammatory markers in managing the health of neurodivergent individuals.

31 Jul 2024

Chronic Urticaria: Addressing unmet needs, emerging therapies, and advances in personalized treatment approaches

Emerging personalized treatment approaches for chronic urticari.

16 Jul 2024

Hidden threats in plant-based diets: Rising allergies to lesser-known legumes

Researchers have identified emerging legume allergens like peas, lentils, and lupines, calling for more extensive studies and better diagnostics to manage increasing allergic reactions. The popularity of plant-based diets has brought new allergenic challenges to light.

15 Jul 2024

Inulin gel-based oral immunotherapy is effective in suppressing food allergy responses and anaphylactic shock

A novel oral immunotherapy platform that uses formulated inulin gel combined with food allergens to orally deliver dietary antigens.

12 Jul 2024

Curcumin-based inhibition of thiol isomerases: A potential treatment for food allergies

Clinton Mathias, associate professor of nutritional sciences in the College of Agriculture, Health and Natural Resources (CAHNR), has discovered a potential new treatment for allergic reactions.

7 Jun 2024

Statins found to prevent chronic inflammation-related cancers by inhibiting interleukin-33

The effects of statins via inhibition of interleukin 33 (IL-33).

3 Jun 2024

Mast cells and PGE2: Key players in controlling asthma inflammation

Previous research indicates that mast cells, a type of immune cell found in the tissues throughout the body, cause inflammation during an asthma attack, inducing symptoms such as trouble breathing and narrowing of the airways.

30 May 2024

Study reveals nerve changes linked to pain and urinary frequency in recurrent UTI sufferers

How sensory nerve sprouting and mast cell activity, driven by nerve growth factor (NGF), contribute to persistent bladder pain and dysfunction in recurrent urinary tract infection (rUTI) cases.

7 Mar 2024

Higher dietary niacin intake linked to lower COPD risk, study finds

Recent research in Scientific Reports reveals a dose-response relationship between dietary niacin intake and reduced prevalence of chronic obstructive pulmonary disease (COPD), suggesting niacin's potential role in mitigating oxidative stress and inflammation in COPD patients.

8 Feb 2024

New insights on how diet regulates allergic responses

The intricate relationship that exists between humans and the gut microbiome has become a hot research topic, and scientists are constantly uncovering new reasons why a healthy diet can lead to a healthier life.

1 Feb 2024

Breakthrough nano-shield blocks selective allergic reactions

Northwestern University researchers have developed the first selective therapy to prevent allergic reactions, which can range in severity from itchy hives and watery eyes to trouble breathing and even death.

16 Jan 2024

Two new practice parameters offer recommendations for treating anaphylaxis and atopic dermatitis

Two new practice parameters from the Joint Task Force for Practice Parameters (JTFPP) offer evidence-based recommendations for the diagnosis and management of anaphylaxis and atopic dermatitis (AD) in pediatric and adult patients.

18 Dec 2023

Blueprint Medicines announces approval of AYVAKYT for treatment of ISM patients in Europe

Blueprint Medicines Corporation today announced the European Commission has approved AYVAKYT® (avapritinib) for the treatment of adult patients with indolent systemic mastocytosis (ISM) with moderate to severe symptoms inadequately controlled on symptomatic treatment. AYVAKYT is the first and only approved therapy for people living with ISM in Europe.

15 Dec 2023

Targeted therapy reduces markers of disease burden, improves symptoms for patients with nonadvanced system mastocytosis

The targeted therapy bezuclastinib was safe and rapidly reduced markers of disease burden while also improving symptoms for patients with a rare blood disorder called nonadvanced system mastocytosis, according to results of the Phase II SUMMIT trial reported by researchers at The University of Texas MD Anderson Cancer Center.

11 Dec 2023

Mast cell receptor linked to alcohol withdrawal-associated headaches

Researchers investigate the role of the mast-cell-specific receptor Mas-related G-protein-coupled receptor B2 (MrgprB2) in alcohol-withdrawal-induced headaches.

2 Nov 2023

Scientists identify mechanism of alcohol withdrawal headaches

About 283 million people worldwide suffer from alcohol use disorder, a debilitating health challenge for which limited therapeutic options are available. The cost to society is estimated at greater than $2 trillion annually.

30 Oct 2023