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Viewpoints: Approving drugs quickly; Berwick: In health care, cheaper can mean better; Health costs 'persistent' concern

For about 20 years, the Food and Drug Administration (FDA) has charged pharmaceutical companies "user fees" for reviewing drug-approval applications. The revenue allows the FDA to hire more evaluators, which allows useful drugs to reach patients faster. Now the Prescription Drug User Fee Act needs reauthorization, as it does every five years. Legislators should not dillydally.

15 May 2012

Narrower CRAE may increase risk of CVD among African Americans with type 1 diabetes

Among African Americans with type 1 diabetes mellitus, narrower central retinal arteriolar equivalent (average diameter of the small arteries in the retina) is associated with an increased risk of six-year incidence of any cardiovascular disease and lower extremity arterial disease, according to a report in the May issue of Archives of Ophthalmology, a JAMA Network publication.

15 May 2012

Differences in regional readmission rates for heart failure tied to socioeconomics, availability of care

Differences in regional hospital readmission rates for heart failure are more closely tied to the availability of care and socioeconomics than to hospital performance or patients' degree of illness, according to research presented at the American Heart Association's Quality of Care & Outcomes Research Scientific Sessions 2012.

14 May 2012

Bacteria in digestive tracts compete against invading bacteria

From tiny villages in developing nations to suburban kitchens in the United States, dangerous strains of E. coli bacteria sicken millions of people each year - and kill untold numbers of children.

11 May 2012

RNP granules exit the nucleus via new budding mechanism akin to herpes-type viruses

New evidence published in Cell by Vivian Budnik, PhD, Melissa J. Moore, PhD, and colleagues at the University of Massachusetts Medical School, reveals a novel budding mechanism, similar to the process used by some viruses, capable of exporting large ribonucleoprotein particles from the nucleus to the cytoplasm.

11 May 2012

Checking for specific genetic variants can help identify women at high risk of PND

Researchers at Warwick Medical School have discovered a way of identifying which women are most at risk of postnatal depression (PND) by checking for specific genetic variants.

10 May 2012

Lenalidomide improves overall survival for patients with multiple myeloma

Data from the first large U.S. study assessing the effectiveness of long-term "maintenance" therapy with lenalidomide for patients with multiple myeloma show that the drug significantly improves the time to progression and overall survival for patients with this often-deadly hematologic cancer.

10 May 2012

New study to measure effectiveness of Vitamin B12 in preventing gestational diabetes

New MRC-funded research underway to measure effectiveness of Vitamin B12 supplement in preventing gestational diabetes in mothers and obestity in later life.

9 May 2012

New clue to predicting pre-eclampsia, the most common and severe pregnancy-related disease

An indication of whether a mother will develop pre-eclampsia, the most common and severe pregnancy-related disease, has been identified by a University of Sydney study.

9 May 2012

Rutin may inhibit formation of blood clots

A compound called rutin, commonly found in fruits and vegetables and sold over the counter as a dietary supplement, has been shown to inhibit the formation of blood clots in an animal model of thrombosis.

9 May 2012

Two studies suggest long-term value of Deplin in treating MDD

Two studies presented this week at the 164th Annual Meeting of the American Psychiatric Association suggest the long-term value of Deplin (L-methylfolate 15mg) in treating major depressive disorder (MDD) and describe subsets of patients who may benefit more robustly from this medical food.

9 May 2012

Women & Infants Hospital to receive Health Care Innovation award

Health and Human Services Secretary Kathleen Sebelius today announced that Women & Infants Hospital of Rhode Island is among the first batch of organizations selected for Health Care Innovation awards. Made possible by the health care law - the Affordable Care Act - the awards will support 26 innovative projects nationwide that will save money, deliver high quality medical care, and enhance the health care workforce. The preliminary awardees announced today expect to reduce health spending by $254 million over the next three years.

9 May 2012

U.S. healthcare system could be burdened with 32 million more obese people within two decades

Researchers have forecast the cost savings and rise in obesity prevalence over the next two decades in a new public health study.

8 May 2012

Brief empathy training program improves resident physicians interactions with patients

Resident physicians' participation in a brief training program designed to increase empathy with their patients produced significant improvement in how patients perceived their interactions with the residents.

8 May 2012

Long-term exposure to roadways linked with increased risk of death in patients with heart attack

Living close to a major highway poses a significant risk to heart attack survivors, reinforcing the need to isolate housing developments from heavy traffic areas, a Beth Israel Deaconess Medical Center study concludes.

8 May 2012

Pall in-line filters can reduce severe complications, length of hospital stay in PICU

A recently published clinical study on infusion therapy indicates in-line filters from Pall Corporation can reduce severe complications and the length of a patient's stay in the pediatric intensive care unit.

From Pall Corporation 8 May 2012

T2M cells play a crucial role in treatment-resistant asthma

For most people with asthma, a couple of puffs from an inhaler filled with steroids makes breathing easy. But if their lungs become resistant to the calming effect of that medicine, they live in fear of severe asthma attacks that could send them to the hospital - or worse. Now, new research from the University of Michigan Health System may help explain what's going on in the lungs of these steroid-resistant individuals. The findings could aid the development of new treatment options, and of better ways to identify people at risk of becoming steroid-resistant.

8 May 2012

Data from Idera IMO-8400 preclinical studies for SLE and psoriasis presented at AAI meeting

Idera Pharmaceuticals, Inc. today announced data from preclinical studies of IMO-8400, demonstrating a novel mechanism of action that may be applicable to the treatment of systemic lupus erythematosus (SLE) and psoriasis. IMO-8400 is an inhibitor of specific Toll-like receptors (TLRs).

7 May 2012

Researchers make white fat take on characteristics of brown fat

Brown seems to be the color of choice when it comes to the types of fat cells in our bodies. Brown fat expends energy, while its counterpart, white fat stores it. The danger in white fat cells, along with the increased risk for diabetes and heart disease it poses, seems especially linked to visceral fat. Visceral fat is the build-up of fat around the organs in the belly.

7 May 2012

Human stem cells effective in treating muscular dystrophy

Researchers from the University of Minnesota's Lillehei Heart Institute have effectively treated muscular dystrophy in mice using human stem cells derived from a new process that - for the first time - makes the production of human muscle cells from stem cells efficient and effective.

5 May 2012

Medical School News and Research

Viewpoints: Approving drugs quickly; Berwick: In health care, cheaper can mean better; Health costs 'persistent' concern

Narrower CRAE may increase risk of CVD among African Americans with type 1 diabetes

Differences in regional readmission rates for heart failure tied to socioeconomics, availability of care

Bacteria in digestive tracts compete against invading bacteria

RNP granules exit the nucleus via new budding mechanism akin to herpes-type viruses

Checking for specific genetic variants can help identify women at high risk of PND

Lenalidomide improves overall survival for patients with multiple myeloma

New study to measure effectiveness of Vitamin B12 in preventing gestational diabetes

New clue to predicting pre-eclampsia, the most common and severe pregnancy-related disease

Rutin may inhibit formation of blood clots

Two studies suggest long-term value of Deplin in treating MDD

Women & Infants Hospital to receive Health Care Innovation award

U.S. healthcare system could be burdened with 32 million more obese people within two decades

Brief empathy training program improves resident physicians interactions with patients

Long-term exposure to roadways linked with increased risk of death in patients with heart attack

Pall in-line filters can reduce severe complications, length of hospital stay in PICU

T2M cells play a crucial role in treatment-resistant asthma

Data from Idera IMO-8400 preclinical studies for SLE and psoriasis presented at AAI meeting

Researchers make white fat take on characteristics of brown fat

Human stem cells effective in treating muscular dystrophy

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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