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PLX4032 trial shows high degree of selectivity to achieve tumor shrinkage

Plexxikon today announced publication of key data in this week's edition of Nature demonstrating that the high degree of selectivity of PLX4032 (RG7204) enables substantial RAF/MEK/ERK pathway inhibition, which may be necessary to achieve significant tumor shrinkage and clinical response in patients with BRAF mutant melanoma.

8 Sep 2010

Risk factors for indoor and outdoor falls for elderly adults are different: Study

The risk factors for indoor and outdoor falls for older adults are different, according to a new study by the Institute for Aging Research of Hebrew SeniorLife, an affiliate of Harvard Medical School, a fact that is often missed when the two are combined and may affect how falls prevention programs are structured.

8 Sep 2010

NIH announces $161.3 million for expansion of Pharmacogenomics Research Network

The National Institutes of Health plans to spend $161.3 million over the next five years to expand the Pharmacogenomics Research Network (PGRN), a nationwide collaborative of scientists focused on understanding how genes affect a person's response to medicines.

8 Sep 2010

Risks of 'imported' measles

An outbreak of measles at an international youth soccer event illustrates the risks of with "imported" measles, according to a study in the September issue of The Pediatric Infectious Disease Journal. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health, a leading provider of information and business intelligence for students, professionals, and institutions in medicine, nursing, allied health, and pharmacy.

8 Sep 2010

Global warming may eliminate plague

While many climate experts and environmentalists explore the negative effects of global warming, a new study reveals a positive outcome of the warming of the planet: the potential elimination of the plague. Global warming affects temperatures and precipitation regimes that play a pivotal role in the lives of rodents and fleas; rodents and fleas are responsible for maintenance and spread of plague to human populations. Plague can be fatal if the symptoms are not recognized and treated within 24 hours.

8 Sep 2010

Scientists gather to present research findings at ASHG 2010 Meeting

The world's top scientists and clinicians in the human genetics field will gather in Washington, D.C., to present their latest research findings at the 60th Annual Meeting of the American Society of Human Genetics, from Tuesday, November 2, through Saturday, November 6, 2010, at the Walter E. Washington Convention Center in D.C.

8 Sep 2010

KRN cell transfer model provides novel opportunity for rheumatoid arthritis research

Current research provides a novel model for rheumatoid arthritis research. The related report by LaBranche et al, "Characterization of the KRN cell transfer model of rheumatoid arthritis, a chronic yet synchronized version of the K/BxN mouse," appears in the September 2010 issue of The American Journal of Pathology.

8 Sep 2010

Phase 3 REALIZE study shows milestone in treatment development for hepatitis C

Vertex Pharmaceuticals Incorporated today announced that 65% of people overall achieved a sustained viral response (SVR or viral cure) with a telaprevir-based regimen in the pivotal Phase 3 REALIZE study, as compared to 17% of people in the control arm who received pegylated-interferon and ribavirin alone.

8 Sep 2010

Personalized reminders effective in encouraging seniors to get annual flu shots

Personalized post cards or phone calls can be effective in encouraging more seniors to get their annual flu shots, according to a new review of evidence. Professional facilitators are also successful at urging providers to perform a suite of preventive services, including flu shots for seniors.

8 Sep 2010

Research reveals sports injury outcome during 2010 Winter Olympics

At least one in 10 athletes sustained an injury and a further one in 14 fell ill during the 2010 Winter Olympics, held in Canada, reveals research published in the British Journal of Sports Medicine.

8 Sep 2010

NIH announces award to improve human microbiome research

The National Institutes of Health today announced it has awarded approximately $42 million to expand the scope of eight demonstration projects designed to link changes in the human microbiome to health and disease.

8 Sep 2010

UC San Diego researchers receive grant to study pharmacogenomics for bipolar disorder

An international team, led by University of California, San Diego School of Medicine researchers, has been awarded a $6.5 million grant from the National Institutes of Health (NIH) to study the pharmacogenomics of a key mood-stabilizing drug used to treat bipolar disorder.

8 Sep 2010

NIH expands funding for Baylor College of Medicine Human Microbiome Project

The National Institutes of Health today announced expanded funding of the Baylor College of Medicine Human Microbiome Project clinical program initiated last year at Texas Children Hospital.

8 Sep 2010

Study finds increase in emergency department usage among US patients

Only 45 percent of the 354 million annual visits for acute care in the United States are made to patients' personal physicians, as Americans increasingly make busy emergency departments, specialists or outpatient care departments their first point of contact for treatment of new health problems or a flare up of a chronic condition like asthma or diabetes.

8 Sep 2010

Dispensary of Hope adds seven new sites

The Dispensary of Hope, a Nashville-based not-for-profit social venture, is pleased to announce that seven new sites across the nation have been added to the Dispensary network, bringing the total number of sites to almost eighty. Apart from Tennessee, the locations of new sites include Pennsylvania, Michigan, Louisiana and Alabama, widening the scope of the Dispensary and providing opportunities to many different communities.

8 Sep 2010

San Antonio podiatrist offers new MLS Therapy for pain management

Dr. Ed Davis, a podiatrist with offices in San Antonio, TX and Live Oak, TX, announces the immediate offering of a new form of laser therapy to patients in the San Antonio area. The addition is part of Dr. Davis' continued investment in advanced technologies and progressive procedures.

8 Sep 2010

Study finds non-hormonal therapies can relieve hot flashes in women with breast cancer

Many women enduring hot flashes experience the heat, sweat and reddened upper body as an uncomfortable inconvenience. However, hot flashes can greatly diminish a woman's quality of life, disrupting sleep at night or causing embarrassment as she goes about her daily business. Many women enduring hot flashes experience the heat, sweat and reddened upper body as an uncomfortable inconvenience. However, hot flashes can greatly diminish a woman's quality of life, disrupting sleep at night or causing embarrassment as she goes about her daily business.

8 Sep 2010

Researchers discover tolerance mechanism in chronic morphine treatment

Researchers from Mount Sinai School of Medicine have discovered a major mechanism underlying the development of tolerance to chronic morphine treatment. The discovery may help researchers find new therapies to treat chronic pain, and reduce tolerance and side effects associated with morphine use. The findings are published in the July 20th issue of Science Signaling.

8 Sep 2010

Local efforts seek to reduce childhood obesity; Sleep-deprived kids most vulnerable

NPR: "[A] new study finds that even for infants and preschoolers, a good, long night's sleep may be just as important as diet and physical activity. Over the past three decades, obesity rates have doubled among children age 2 to 5, and tripled among 6- to 11-year-olds. So University of Washington maternal and child health researcher Janice Bell wanted to know whether sleep had anything to do with it.

8 Sep 2010

NIH awards St. Jude $8.6M to focus on anticancer agent research in children

With its new expansion of the Pharmacogenomics Research Network (PGRN), the National Institutes of Health (NIH) awarded St. Jude Children's Research Hospital a prestigious grant to focus on anticancer agent research in children.

8 Sep 2010