Metabolic Disease News and Research

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New test identifies CAD-affected children who may benefit from uridine

Scientists at Sanford Burnham Prebys Medical Discovery Institute and the Centro de Biología Molecular Severo Ochoa in Spain have created a test that determines which children with CAD deficiency-; a rare metabolic disease-; are likely to benefit from receiving uridine, a nutritional supplement that has dramatically improved the lives of other children with the condition.

3 Jun 2020

Temple research suggests new way to prevent abdominal aortic aneurysm therapeutically

The main thoroughfare that carries oxygen-rich blood from the heart to the abdomen is known as the abdominal aorta.

28 May 2020

Study reveals mechanism involved in the development of diabetes, fatty liver

A research group including Professor OGAWA Wataru (Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine) and Project Associate Professor HOSOOKA Tetsuya (Division of Development of Advanced Therapy for Metabolic Disease, Kobe University Graduate School of Medicine) has clarified the mechanism underlying the development of diabetes and non-alcoholic steatohepatitis (NASH), a severe form of fatty liver.

22 May 2020

Child abuse survivors more likely to develop cardio-metabolic disease in adulthood

People who have experienced maltreatment during childhood are significantly more likely to develop conditions such as heart disease, high blood pressure and type two diabetes in adulthood, a new UK study has found.

15 May 2020

Link found between blood vessel inflammation and abnormalities in mitochondrial fission

The vast majority of cells in the human body contain tiny power plants known as mitochondria that generate much of the energy cells use for day-to-day activities.

11 May 2020

Different types of white fat may play distinct roles in metabolic diseases

Excess white fat causes obesity, which in turn can drive diabetes and many other metabolic diseases that are growing at epidemic rates around the world.

5 May 2020

Study: JNK and BNP activity can reverse cardiovascular damage, reduce risk of death from sepsis

Overreaction is rarely useful, and in the case of the human immune system, it can be outright deadly. When the body overreacts to an infection, the result is sepsis - a life-threatening condition that frequently leads to acute organ dysfunction, including deterioration of the heart and blood vessels, which make up the cardiovascular system.

24 Apr 2020

A protein discovery could pave way to better treatments for obesity

A USC-led international team of scientists has found the precise shape of a key player in human metabolism, which could lead the way to better treatments for obesity and other metabolic disease.

23 Apr 2020

Role of ACE/ARB inhibitors in the treatment of COVID-19

A new opinion piece published in the journal Circulation Research in April 2020 defends the use of antihypertensive drugs called ACE inhibitors and ARBs in patients with pandemic viral pneumonia called COVID-19.

20 Apr 2020

Study reveals how hormone leptin contributes to weight loss

Some call it baby fat. But recent research has shown that adults have it too--which is a good thing. Brown fat, the so-called good fat that can protect against obesity and associated health risks, like cardiovascular disease and diabetes, is located in small pockets throughout the body.

31 Mar 2020

Revita DMR therapy has potential to transform lives of patients with poorly controlled type 2 diabetes

Patients with poorly controlled type 2 diabetes who underwent a novel, minimally invasive, endoscopic procedure called Revita duodenal mucosal resurfacing had significantly improved blood glucose (sugar) levels, liver insulin sensitivity, and other metabolic measures three months later, according to new data from the REVITA-2 study.

30 Mar 2020

Factors causing childhood obesity differ for wealthier and poorer countries

Childhood obesity is not just a public health concern in western countries; it is rising across the world, particularly in poor and low-income countries.

26 Mar 2020

Men who had early puberty at higher risk of type 2 diabetes

A man who experienced the onset of puberty earlier than usual is at a higher risk of developing type 2 diabetes as an adult, compared to boys who have later puberty. This trend does not depend on childhood weight. The study, published in the journal Diabetologia in March 2020, may help establish guidelines for prevention and testing for diabetes in men.

23 Mar 2020

The cost of excessive sugar in the diet

A new study from the MRC London Institute of Medical Sciences, in the UK, reports that while eating foods rich in sugar does not necessarily make you fat, they can make you very sick. They do this by increasing the level of a compound called uric acid in the blood. The study is published in the journal Cell Metabolism in March 2020.

19 Mar 2020

Dietary sugar has negative impact on health independent of obesity

Sugar-rich diets have a negative impact on health independent of obesity reports a new study led by the MRC London Institute of Medical Sciences, UK.

19 Mar 2020

Gene therapy reverses cardiac dysfunction in mice with Barth syndrome

Barth syndrome is a rare metabolic disease in boys caused by mutation of a gene called tafazzin or TAZ. It can cause life-threatening heart failure and also weakens the skeletal muscles, undercuts the immune response, and impairs overall growth.

9 Mar 2020

Sex-specific differences in the immune system may explain men's susceptibility to obesity

Melbourne researchers have uncovered important differences between the male and female immune system which may explain why men are more susceptible to obesity and metabolism-related associated diseases, such as heart disease, stroke and diabetes.

26 Feb 2020

High testosterone in women ups risk for cancer, diabetes, and metabolic disease

Testosterone is a steroid hormone that triggers the development of male secondary sex characteristics. Though found mainly in men, the ovaries in women release small amounts of testosterone. When combined with estrogen, testosterone aids in the growth and repair of a woman's reproductive tissues.

12 Feb 2020

Long noncoding RNA can protect our metabolism against metabolic complications

Unlike what we commonly refer to as 'genes', these phantom genes or 'Long noncoding RNA' (LncRNAs) do not lead to the production of proteins that our cells, and thus our entire bodies are made of.

31 Jan 2020

Research uncovers disease-aggravating mutation in mouse model of GRACILE syndrome

The new mitochondrial DNA (mtDNA) variant drastically speeds up the disease progression in a mouse model of GRACILE syndrome. This discovery provides a new tool for studies of mitochondrial diseases.

29 Jan 2020