Metabolic Disease News and Research

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EAT2 study to investigate adipose tissue responses to weight change

Dr. Ursula White, an associate professor of Clinical Science at Pennington Biomedical Research Center, is taking a deep dive into the lasting health effects of short-term weight gain and weight loss.

20 Oct 2024

Grant supports gene-editing research for rare metabolic diseases

A $14M grant will fund research on gene-editing therapies for rare metabolic diseases at the Perelman School of Medicine at the University of Pennsylvania (Penn) and Children's Hospital of Philadelphia (CHOP).

10 Oct 2024

New insights into how stress affects pancreatic cells and diabetes risk

The cells in your pancreas, like people, can only handle so much stress before they start to break down. Certain stressors, such as inflammation and high blood sugar, contribute to the development of type 2 diabetes by overwhelming these cells.

8 Oct 2024

Ketogenic diet lowers mortality by 24% while maintaining heart health

Study confirms that adherence to a ketogenic diet reduces all-cause mortality risk by 24% without increasing cardiovascular mortality in a large US cohort. Findings support KD as a beneficial intervention for long-term health.

3 Oct 2024

Time-restricted eating could offer health benefits to adults with metabolic syndrome

More than one-third of adults in the United States have metabolic syndrome, a cluster of conditions that significantly raise a person's risk of heart disease, stroke, and type 2 diabetes.

1 Oct 2024

Regulating iron overload: Liraglutide's potential benefits

Researchers assess the role of liraglutide in regulating iron metabolism in a mouse model of hereditary hemochromatosis.

30 Sep 2024

Hypothalamic ECM remodeling drives insulin resistance, contributing to obesity and diabetes

Researchers have discovered that remodeling of extracellular matrix (ECM) in the hypothalamus, specifically around AgRP neurons, drives insulin resistance and metabolic disease. Disrupting this ECM buildup improves insulin sensitivity and may be a promising treatment for obesity and diabetes.

19 Sep 2024

Cellular sludge around hunger neurons linked to worsening diabetes and obesity

Investigating ECM changes in the hypothalamus reveals mechanisms behind insulin resistance, offering insights into obesity and metabolic disease treatment.

19 Sep 2024

Sulthiame shows promise in reducing obstructive sleep apnea symptoms

Patients taking sulthiame, a drug currently in use for epilepsy, experienced a reduction in their symptoms of obstructive sleep apnoea (OSA), according to results of a clinical trial presented at the European Respiratory Society (ERS) Congress in Vienna, Austria.

10 Sep 2024

New smart mask monitors breath for real-time health analysis

Personalized wearable devices that monitor people's health are on the rise. From watches to patches and other types of sensors, these smart devices can monitor heart activity, inflammation levels, and more to help patients better manage their health from their own homes.

29 Aug 2024

New 3D imaging tool offers accurate assessment of metabolic health

Mayo Clinic researchers are using artificial intelligence (AI) with an advanced 3D body-volume scanner – originally developed for the clothing industry – to help doctors predict metabolic syndrome risk and severity.

22 Aug 2024

Study reveals new insights into urea cycle's role in fatty liver disease

An Indiana University School of Medicine physician scientist is making strides in understanding the molecular origins of fatty liver disease, a leading cause of liver failure in the United States.

16 Aug 2024

New target identified to combat menopause-induced obesity

A decline in estrogen during menopause causes changes in body fat distribution and associated cardiovascular and metabolic disease, but a new study identifies potential therapies that might one day reverse these unhealthy shifts.

16 Aug 2024

Early exposure to 'forever chemicals' alters gut microbiome and increases metabolic disease risk

Early life exposure to 'forever chemicals' in the environment permanently disrupts the gut microbiome in mice, contributing to the development of metabolic disease in later life, according to new research led by Penn State.

14 Aug 2024

IU research sheds light on urea cycle defects and fatty liver disease

An Indiana University School of Medicine physician scientist is making strides in understanding the molecular origins of fatty liver disease, a leading cause of liver failure in the United States.

13 Aug 2024

Consuming foods with erythritol increases risk of cardiovascular events, study shows

New Cleveland Clinic research shows that consuming foods with erythritol, a popular artificial sweetener, increases risk of cardiovascular events such as heart attack and stroke.

8 Aug 2024

Xanthones show promise in diabetes with antioxidant and anti-inflammatory properties

Research reveals xanthones as promising agents in diabetes management, offering antioxidant, anti-inflammatory, and insulin-sensitizing benefits.

29 Jul 2024

New four-year initiative targets cardiovascular-kidney-metabolic syndrome

About 1 in 3 U.S. adults have at least three risk factors for cardiovascular-kidney-metabolic (CKM) syndrome, a health disorder related to the strong connections among cardiovascular disease, kidney disease and metabolic disease (such as Type 2 diabetes and obesity).

18 Jul 2024

Researchers find a special group of "first responder" cells crucial for triggering blood sugar response

How does our body control blood sugar so precisely? An international research team led by scientists from the Paul Langerhans Institute Dresden (PLID) of the German Center for Diabetes Research brought us a step closer to the answer.

17 Jul 2024

Immunotherapy response assessment in malignant pleural mesothelioma: FDG-PET/CT vs. CT

A new research paper was published in Oncotarget's Volume 15 on June 20, 2024, entitled, "Comparison of FDG-PET/CT and CT for evaluation of tumor response to nivolumab plus ipilimumab combination therapy and prognosis prediction in patients with unresectable malignant pleural mesothelioma."

15 Jul 2024