Metabolic Disease News and Research

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ATS: Withdrawing sleep apnea screening for truck drivers, train engineers puts lives at risk

The American Thoracic Society is extremely disappointed with the Department of Transportation's decision to withdraw an advance notice of a proposed rule regarding screening commercial truck drivers and train engineers for sleep apnea.

11 Aug 2017

"Fat switch" may hold the key to obesity finds new study

Scientists have been trying for years now to understand what causes overweight and obesity in some but not in others. Now researchers at the Monash University's Biomedicine Discovery Institute seem to have solved the puzzle that has been baffling them all – a so called “fat switch” in the brain that regulates weight gain. This could also mean a new potential for treatment of obesity in future. The study appeared in the journal Cell Metabolism today.

1 Aug 2017

DZHK study shows physical stress as risk factor for broken heart syndrome

The loss of a loved one, a dispute with your neighbor, infections or a fall - mental and physical stress can be triggers of a broken heart (broken heart syndrome). What is more, physical stress seems to be more dangerous than emotional stress, a study of the German Centre for Cardiovascular Research shows.

20 Jun 2017

Study: Type 2 diabetes linked to bacteria that penetrate mucus lining of the colon

In humans, developing metabolic disease, particularly type 2 diabetes, is correlated with having bacteria that penetrate the mucus lining of the colon, according to a study led by Drs. Benoit Chassaing and Andrew Gewirtz at Georgia State University.

30 May 2017

Clinical study tests 100-year-old drug in children with autism spectrum disorder

In a small, randomized Phase I/II clinical trial (SAT1), researchers at University of California San Diego School of Medicine say a 100-year-old drug called suramin, originally developed to treat African sleeping sickness, was safely administered to children with autism spectrum disorder (ASD), who subsequently displayed measurable, but transient, improvement in core symptoms of autism.

26 May 2017

Endoplasmic reticulum stress in the brain may cause non-alcoholic fatty liver disease

Disruptions in a protein folding process occurring in the brain, known as endoplasmic reticulum (ER) stress, may cause non-alcoholic fatty liver disease, independent of other factors. A research team at the George Washington University published their results in the Journal of Clinical Investigation Insight.

25 May 2017

Study shows first removal of HIV-1 replication using CRISPR/Cas9, gene editing technology

A new study published in the journal Molecular Therapy reveals that HIV DNA in the genome of living animals can be removed to eliminate further infection. While a permanent cure for infection caused by HIV remains a challenge due to the ability of the virus to hide away in latent reservoirs. The study team comprising Wenhui Hu, Kamel Khalili, Laura H. Carnell, and Won-Bin Young carried out an experiment on three different animal models.

4 May 2017

New study shows that gene editing technology can shut down HIV-1 replication in animals

A permanent cure for HIV infection remains elusive due to the virus's ability to hide away in latent reservoirs. But now, in new research published in print May 3 in the journal Molecular Therapy, scientists at the Lewis Katz School of Medicine at Temple University and the University of Pittsburgh show that they can excise HIV DNA from the genomes of living animals to eliminate further infection.

2 May 2017

Brown fat in humans: more than previously thought

Brown fat is a tissue well studied in small mammals, where it acts as a heat-producing organ to stay warm in a cold environment. Its unequivocal identification in adult, healthy humans about a decade ago is of major importance due to its immense capacity to convert chemical energy into heat

20 Apr 2017

New study reveals sympathetic nervous system as main driver of thermogenesis

A new study from the Icahn School of Medicine at Mount Sinai provides important insights into how the body regulates its production of heat, a process known as thermogenesis that is currently intensely studied as a target of diabetes and obesity treatment in humans.

17 Apr 2017

Study describes synthesis and biological evaluation of novel, effective ARIs

Diabetes mellitus (DM) is probably one of the oldest known diseases and the incidence has been increasing steadily all over the world. This metabolic disease is characterized by chronic hyperglycemia due to defect in insulin secretion and/or insulin action.

17 Apr 2017

PID1 gene increases killing effect of chemotherapy drugs on brain tumor cells

Investigators at The Saban Research Institute of Children's Hospital Los Angeles have found that the gene PID1 enhances killing of medulloblastoma and glioblastoma cells.

11 Apr 2017

Women have statistically lower incidence of severe psoriasis compared to men, study reveals

The fact that men are overrepresented in psoriasis registers and consume more psoriasis care have long led researchers to believe that the common skin disease disproportionally affects men.

24 Mar 2017

Novel androgens play major role in development of PCOS, research shows

Scientists led by the University of Birmingham have discovered that a new class of male sex hormones known as androgens plays a key role in the development of polycystic ovary syndrome (PCOS).

13 Mar 2017

Factors contributing to childhood adiposity begin before birth, study shows

A new article, published in the journal BMC Medicine, reports the largest epigenome-wide association study to date that provides evidence that factors contributing to childhood adiposity (level of body fat) begin before birth and are influenced by mother’s lifestyle, and fetal genetic and epigenetic factors.

9 Mar 2017

Penn researchers identify genome-wide changes caused by high-fat diet

By comparing two strains of mice -- one that becomes obese and diabetic on a high-fat diet and another resistant to a high-fat regimen -- researchers from the Perelman School of Medicine at the University of Pennsylvania identified genome-wide changes caused by a high-fat diet.

8 Mar 2017

Metabolic Disease News and Research

ATS: Withdrawing sleep apnea screening for truck drivers, train engineers puts lives at risk

"Fat switch" may hold the key to obesity finds new study

DZHK study shows physical stress as risk factor for broken heart syndrome

Study: Type 2 diabetes linked to bacteria that penetrate mucus lining of the colon

Clinical study tests 100-year-old drug in children with autism spectrum disorder

Endoplasmic reticulum stress in the brain may cause non-alcoholic fatty liver disease

Study shows first removal of HIV-1 replication using CRISPR/Cas9, gene editing technology

New study shows that gene editing technology can shut down HIV-1 replication in animals

Brown fat in humans: more than previously thought

New study reveals sympathetic nervous system as main driver of thermogenesis

Study describes synthesis and biological evaluation of novel, effective ARIs

PID1 gene increases killing effect of chemotherapy drugs on brain tumor cells

Women have statistically lower incidence of severe psoriasis compared to men, study reveals

Novel androgens play major role in development of PCOS, research shows

Factors contributing to childhood adiposity begin before birth, study shows

Penn researchers identify genome-wide changes caused by high-fat diet

Scientists track 'guardian immune cells' to uncover mechanics underlying inflammation and obesity

BIDMC review focuses on neural circuitry of wakefulness and sleep

Mice study provides clues to how genetic variations in gut microbes influence metabolic disease

Study shows way to counteract junk-food eating cycle

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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