Metabolic Disorders News and Research

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Rare amino acid helps establish how proteins evolve

Three billion years ago, a "new" amino acid was added to the alphabet of 20 that commonly make up proteins in organisms today.

29 Jan 2009

Low-carb diet burns more excess liver fat than low-cal diet

People on low-carbohydrate diets are more dependent on the oxidation of fat in the liver for energy than those on a low-calorie diet, researchers at UT Southwestern Medical Center have found in a small clinical study.

23 Jan 2009

High-fat diet can disrupt our biological clock

Indulgence in a high-fat diet can not only lead to overweight because of excessive calorie intake, but also can affect the balance of circadian rhythms - everyone's 24-hour biological clock, Hebrew University of Jerusalem researchers have shown.

29 Dec 2008

Pigs and dogs can bridge gap between mice and humans in developing new therapies

Human and veterinary medicine could receive a big boost through use of larger animals, especially pigs and dogs, in research, with Europe at the forefront.

16 Dec 2008

3.6 million Americans living with active, undiagnosed psoriasis, unaware of associated risks

Armed with research concluding that psoriasis is associated with an increased risk of heart attacks and other cardiovascular conditions, Joel M. Gelfand, MD, MSCE, Assistant Professor of Dermatology at the University of Pennsylvania School of Medicine and colleagues released an editorial consensus in the American Journal of Cardiology today¸ calling for psoriasis patients to be educated about and screened for cardiovascular risk factors.

15 Dec 2008

Paliperidone palmitate shows positive results for treatment of schizophrenia

Paliperidone palmitate, an investigational long-acting therapy (LAT) demonstrated statistically significant symptom control compared with placebo according to the results of a 13-week study.

14 Dec 2008

Overactive brain enzyme may play role in preventing weight gain and obesity

Researchers at Albert Einstein College of Medicine of Yeshiva University have found that overactivity of a brain enzyme may play a role in preventing weight gain and obesity.

14 Dec 2008

Adropin protein produced by the liver sends signal that fat is on the way in response to high-fat foods

After you eat a burger and fries or other fat-filled meal, a protein produced by the liver may send a signal that fat is on the way, suggests a report in the December issue of the journal Cell Metabolism , a Cell Press publication.

3 Dec 2008

Understanding lipid storage

Magazine articles describing ways to burn fat, lose weight, etc. are omnipresent in Western culture, but science's understanding of the way fat is stored in the cells of the human body is rather slimmer.

24 Nov 2008

Sleep disorders linked to eye disease

If a good night's sleep helps the brain and body perform better, it's a good guess that sleep problems can cause more than just fatigue.

11 Nov 2008

Sleep disorder linked to eye disease

Research has already suggested that sleep problems can cause more than just tiredness - they have been linked to cardiovascular disease, cerebrovascular disease and metabolic disorders, and are also thought to raise the risk of obesity and diabetes.

10 Nov 2008

Investigational drug, MK-677 shows promise for reducing age-related frailty

Researchers at the University of Virginia Health System report that a daily single oral dose of an investigational drug, MK-677, increased muscle mass in the arms and legs of healthy older adults without serious side effects, suggesting that it may prove safe and effective in reducing age-related frailty.

5 Nov 2008

Resveratrol type drug mimics low-cal diet to ward off weight gain

A drug designed to specifically hit a protein linked to the life-extending benefits of a meager diet can essentially trick the body into believing food is scarce even when it isn't, suggests a new report in the November Cell Metabolism.

5 Nov 2008

Apelin hormone shows promise as target for managing insulin resistance and type 2 diabetes

By injecting a hormone produced by fat and other tissues into mice, researchers report in the November Cell Metabolism that they significantly lowered blood sugar levels in normal and obese mice.

5 Nov 2008

Anti-frailty pill for seniors in the pipeline

An 'anti-frailty' pill for seniors could be in the pipeline - the pill which increases muscle mass in arms and legs of older adults is the brainchild of researchers at the University of Virginia Health System.

5 Nov 2008

New weapon in the fight against obesity and diabetes

A study appearing November 5 in the journal Cell Metabolism demonstrates that a synthetic new chemical entity protects against diet-induced obesity, improves glucose tolerance and insulin sensitivity and enhances exercise endurance by enhancing fat utilization in certain target tissues.

4 Nov 2008

Gene variant boosts risk of fatty liver disease

Researchers at UT Southwestern Medical Center have found that individuals who carry a specific form of the gene PNPLA3 have more fat in their livers and a greater risk of developing liver inflammation.

25 Sep 2008

Researchers find cause of severe metabolic disorders

A healthy body stores fat in the form of so-called triglycerides in specialized fatty tissue as an energy reserve.

9 Sep 2008

Atomic structure of the mammalian "fatty acid factory" determined

Mammalian fatty acid synthase is one of the most complex molecular synthetic machines in human cells. It is also a promising target for the development of anti-cancer and anti-obesity drugs and the treatment of metabolic disorders. Now researchers at ETH Zurich have determined the atomic structure of a mammalian fatty acid synthase. Their results have just been published in Science magazine.

7 Sep 2008

New hope for treating common form of inherited neuromuscular disease

Treatments that ramp up production of the tiny "motors" that power cells may have promise for treating one of the most common forms of inherited neuromuscular disease, according to a report in the September Cell Metabolism, a Cell Press publication. Neuromuscular disorders caused by defects in those mitochondrial motors affect a large number of children and adults worldwide, but today remain without treatment, the researchers said.

3 Sep 2008

Metabolic Disorders News and Research

Rare amino acid helps establish how proteins evolve

Low-carb diet burns more excess liver fat than low-cal diet

High-fat diet can disrupt our biological clock

Pigs and dogs can bridge gap between mice and humans in developing new therapies

3.6 million Americans living with active, undiagnosed psoriasis, unaware of associated risks

Paliperidone palmitate shows positive results for treatment of schizophrenia

Overactive brain enzyme may play role in preventing weight gain and obesity

Adropin protein produced by the liver sends signal that fat is on the way in response to high-fat foods

Understanding lipid storage

Sleep disorders linked to eye disease

Sleep disorder linked to eye disease

Investigational drug, MK-677 shows promise for reducing age-related frailty

Resveratrol type drug mimics low-cal diet to ward off weight gain

Apelin hormone shows promise as target for managing insulin resistance and type 2 diabetes

Anti-frailty pill for seniors in the pipeline

New weapon in the fight against obesity and diabetes

Gene variant boosts risk of fatty liver disease

Researchers find cause of severe metabolic disorders

Atomic structure of the mammalian "fatty acid factory" determined

New hope for treating common form of inherited neuromuscular disease

Breaking Barriers: ANDYSMANCLUB's Fight for Men's Mental Health on World Mental Health Day

Arrayed CRISPR Screening for Revolutionizing Target Discovery

Innovations in baculovirus–insect cell expression systems

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