Metabolites News and Research

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Genetic factors may increase person's risk for adverse effects of synthetic cannabinoids

Synthetic cannabinoid abuse is a growing problem in the United States, with new versions of the drugs coming on the market every year. New research is examining how the body processes these man-made drugs and the role that genetics might play in their metabolism.

25 Apr 2017

How physicians can prevent opioid abuse while providing adequate pain relief

Rather than being considered a miracle pill that magically takes away pain, prescription opioids are increasingly being seen as a precursor to heroin addiction and the cause of potentially deadly overdoses themselves.

19 Apr 2017

Vanderbilt geneticists find new way to tap plant pharmacopeia to produce improved therapeutics

Cocaine, nicotine, capsaicin. These are just three familiar examples of the hundreds of thousands of small molecules (also called specialized or secondary metabolites) that plants use as chemical ammunition to protect themselves from predation.

17 Apr 2017

Metabolite produced by intestinal bacteria protects against type 2 diabetes, study shows

A high concentration of indolepropionic acid in the serum protects against type 2 diabetes, shows a new study from the University of Eastern Finland. Indolepropionic acid is a metabolite produced by intestinal bacteria, and its production is boosted by a fibre-rich diet.

11 Apr 2017

Synthetic biologists engineer gut bacteria capable of sensing colitis

Synthetic biologists at Rice University have engineered gut bacteria capable of sensing colitis, an inflammation of the colon, in mice.

6 Apr 2017

Unique metabolic ‘signature’ in urine may help predict development of diabetes in obese teenagers

Researchers have discovered a unique metabolic "signature" in the urine of diabetic, obese black teenagers that they say may become a way to predict the development of type 2 diabetes in people at risk.

4 Apr 2017

Study reveals intriguing crosstalk between metabolism and epigenetics in cancer development

A study published in Briefings in Functional Genomics investigated how epigenetics can modulate human's genetic program -- it can emphasize or silence genes.

24 Mar 2017

Fat cells take over production of uridine from liver during fasting

How do mammals keep two biologically crucial metabolites in balance during times when they are feeding, sleeping, and fasting? The answer may require rewriting some textbooks.

17 Mar 2017

First physiological test opens door to early diagnosis of autism

An algorithm based on levels of metabolites found in a blood sample can accurately predict whether a child is on the Autism spectrum of disorder (ASD), based upon a recent study.

16 Mar 2017

Researchers probe potential link between gut microbiota and poor artery health

Scientific evidence that the assortment of gut microbes in humans influences different and critical aspects of health is piling up: Researchers think our microbes may influence obesity, anxiety, depression, autism, cancer and gastrointestinal diseases.

1 Mar 2017

Decoding the Exposome Through Breath Biomarkers

The human exposome is probably best defined as “everything that is not the genome.” This is a bit tongue in cheek, but basically, the exposome is comprised of all of the chemicals in your body from the environment, food, consumer products, their metabolites, the endogenous “housekeeping” chemicals, the cellular wastes from energy production, as well as all of the messenger compounds and life supporting chemicals.

From Pittcon 24 Feb 2017

Researchers develop new tool that quickly reveals metabolic fluxes in cells

If we were to take photographs at the underground stations in Barcelona, we would see the number of people waiting, find out what time the rush hour takes place and deduce why some stations are busier than others.

23 Feb 2017

Duke Health scientists identify proteins in mucous that confirm viral infection

It may seem obvious, but the key to confirming whether someone is suffering from a cold or flu virus might lie at the misery's source -- the inflamed passages of the nose and throat.

22 Feb 2017

Discovery of early biomarkers paves way for new insight into Huntington's disease

Early warning signs of Huntington's disease have been uncovered in a sheep carrying the human HD mutation, leading the way for new insight into this devastating illness, a new study in Scientific Reports has found.

22 Feb 2017

Melanoma patients' immunotherapy response linked to diversity and makeup of gut bacteria

Melanoma patients' response to a major form of immunotherapy is associated with the diversity and makeup of trillions of potential allies and enemies found in the digestive tract, researchers at The University of Texas MD Anderson Cancer Center report at the ASCO-Society for Immunotherapy in Cancer meeting in Orlando.

22 Feb 2017

UofL researcher receives NIH grant to study microbes responsible for protecting against malaria

Nathan Schmidt, Ph.D., has published research showing that microbes in the gut of mice can affect the severity of illness suffered from infection with Plasmodium, the parasite that causes malaria.

21 Feb 2017

Caffeine cannot prevent memory deficits linked to alcohol consumption, study finds

A study recently published in Frontiers in Behavioral Neuroscience indicates that despite its impact on alertness and concentration, caffeine cannot counteract the memory deficits that result from alcohol consumption.

20 Feb 2017

Mice study provides clues to how genetic variations in gut microbes influence metabolic disease

The community of microorganisms that resides in the gut, known as the microbiome, has been shown to work in tandem with the genes of a host organism to regulate insulin secretion, a key variable in the onset of the metabolic disease diabetes.

17 Feb 2017

Instrument for blood gas and glucose analysis launched by Sphere Medical

Sphere Medical, an innovative company in critical care monitoring and diagnostics equipment, will be showcasing for the first time its next generation Proxima™ blood gas analyser to a German critical care audience at both the Symposium Intensivmedizin + Intensivpflege Bremen and Stuttgarter Intensivkongress.

8 Feb 2017

New research shows that nuts can inhibit growth of cancer cells

Roasted and salted, ground as a baking ingredient or fresh from the shell - for all those who enjoy eating nuts, there is good news from nutritionists at Friedrich Schiller University Jena.

6 Feb 2017

Metabolites News and Research

Genetic factors may increase person's risk for adverse effects of synthetic cannabinoids

How physicians can prevent opioid abuse while providing adequate pain relief

Vanderbilt geneticists find new way to tap plant pharmacopeia to produce improved therapeutics

Metabolite produced by intestinal bacteria protects against type 2 diabetes, study shows

Synthetic biologists engineer gut bacteria capable of sensing colitis

Unique metabolic ‘signature’ in urine may help predict development of diabetes in obese teenagers

Study reveals intriguing crosstalk between metabolism and epigenetics in cancer development

Fat cells take over production of uridine from liver during fasting

First physiological test opens door to early diagnosis of autism

Researchers probe potential link between gut microbiota and poor artery health

Decoding the Exposome Through Breath Biomarkers

Researchers develop new tool that quickly reveals metabolic fluxes in cells

Duke Health scientists identify proteins in mucous that confirm viral infection

Discovery of early biomarkers paves way for new insight into Huntington's disease

Melanoma patients' immunotherapy response linked to diversity and makeup of gut bacteria

UofL researcher receives NIH grant to study microbes responsible for protecting against malaria

Caffeine cannot prevent memory deficits linked to alcohol consumption, study finds

Mice study provides clues to how genetic variations in gut microbes influence metabolic disease

Instrument for blood gas and glucose analysis launched by Sphere Medical

New research shows that nuts can inhibit growth of cancer cells

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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