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How does the antitumor drug get to the cell nucleus?

Platinum complexes such as the well-known cisplatin are powerful antitumor medications. They cross the cell membrane and reach the nucleus, where they attach to DNA and stop cell growth. But how does cisplatin get to the nucleus Italian researchers have now proven that a copper transport protein may play a critical role.

5 Nov 2007

Copper transporter plays an unexpected role in the absorption of cisplatin

30 Oct 2007

Attenuation of NASH by stimulation of free fatty acid metabolism

Medically-complicated obesity is a societal problem that needs to be solved. Liver disease, specifically non-alcoholic steatohepatitis or NASH, is just one of the many complications of increased body weight.

28 Oct 2007

Homocysteine appears to be play a part in retinal damage and vision loss

Homocysteine, an amino acid believed to contribute to heart attack, stroke and dementia, likely also is a player in retinal damage and vision loss, researchers say.

16 Oct 2007

New human genotype may be prone to vCJD

A small study in the British Medical Journal suggests a new human genotype may be prone to variant Creutzfeldt-Jakob disease (vCJD).

6 Jun 2006

vCJD may have infected far more people than previously thought

Scientists at the National CJD Surveillance Unit at the University of Edinburgh say that thousands may be infected with variant Creutzfeldt-Jakob Disease (vCJD) without showing signs or symptoms.

21 May 2006

Creative new therapies for atherosclerotic disease

Patients with a build-up of plaque in arteries in the heart, brain and leg face a high risk of major cardiovascular complications.

14 Mar 2006

Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia

Most people with a rare type of dementia called primary progressive aphasia (PPA) have a specific combination of prion gene variants, a new study shows.

28 Nov 2005

Exploiting biology's own chemical toolbox...

Exploiting biology's own chemical toolbox, researchers have developed a new technique that will allow them to modify specific sequences within a DNA molecule. The approach will not only help reveal the impact of biochemical alterations to DNA, but could have far-reaching implications for DNA-based medical diagnosis and nanobiotechnology.

28 Nov 2005

Antisense molecules may hold promise in treating brain chemical problems such as Alzheimer's

Saint Louis University research shows a new class of drugs may hold promise in treating brain chemical problems such as Alzheimer's disease, says the principal investigator of research published in an early on-line version of Peptides.

25 Oct 2005

Teens with missing part of a chromosome confirm genetic role in schizophrenia

A study in youth who are missing part of a chromosome is further implicating a suspect gene in schizophrenia.

23 Oct 2005

Antioxidants do not prolong the survival of patients with amyotrophic lateral sclerosis, or Lou Gehrig’s disease

A review of recent studies suggests that antioxidant supplements, including vitamin E and selenium, do not prolong the survival of patients with amyotrophic lateral sclerosis, or Lou Gehrig’s disease.

24 Jan 2005

Adding a commonly used dietary supplement to antidepressants may improve treatment

Massachusetts General Hospital (MGH) researchers have found that adding the nutritional supplement SAMe to a standard antidepressant may be helpful to patients who have not responded to single-drug treatment for clinical depression.

30 Nov 2004

New clues about how brain cells are damaged by Alzheimer's disease

University of Kentucky chemistry professor Allan Butterfield has uncovered new clues about how brain cells are damaged by Alzheimer's disease, evidence suggesting vitamin E may help prevent the debilitating illness.

1 Nov 2004

Folate can help women reduce their risk of developing high blood pressure

Young women who consume more than 800 micrograms (ug) of folate per day can reduce their risk of developing high blood pressure by almost a third compared to those who consume less than 200 ug/day, according to new research presented at the American Heart Association's 58th Annual High Blood Pressure Research Conference.

11 Oct 2004

Researchers find new purpose for existing drugs to suppress colon cancer metastasis, secure post-radiation brain function, and trick tumors

Drugs approved for treatment of specific maladies sometimes show unexpected benefits. Researchers at the 95th annual meeting of the American Association for Cancer Research demonstrated highlighted how some drugs may one day offer previously unforeseen benefits for patients.

30 Mar 2004