Microdialysis News and Research

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Microdialysis is a minimally invasive technique that is used for the continuous sampling of extracellular fluid. It is often used to measure the concentration of free analytes that are not bound to carrier proteins in a sample.

Studies provide insight on quality of kidney and liver transplantation

The quality of kidney and liver donations is fundamentally important for the longevity of transplants and the health of recipients. That’s why it’s critical to know which organs are suitable for transplantation, as well as to use techniques that preserve an organ’s function after donation.

29 Apr 2014

Boosting hypocretin could elevate both mood and alertness in humans

What makes us happy? Family? Money? Love? How about a peptide? The neurochemical changes underlying human emotions and social behavior are largely unknown. Now though, for the first time in humans, scientists at UCLA have measured the release of a specific peptide, a neurotransmitter called hypocretin, that greatly increased when subjects were happy but decreased when they were sad.

8 Mar 2013

Mother rats respond much differently to cocaine than non-mothers

Mother rats respond much differently to cocaine than female rats that have never given birth, according to new University of Michigan research that looks at both behavior and brain chemistry.

16 Oct 2012

UMass Amherst neuroscientist to receive 2012 Frank A. Beach Award from SBN

UMass Amherst neuroscientist Luke Remage-Healey will receive the 2012 Frank A. Beach Award from the Society for Behavioral Endocrinology for work showing exceptional promise and significant contributions in the field of behavioral neuroendocrinology. Named after a founder of the field, the award will be presented during the society's annual meeting this week in New Orleans. Remage-Healey will also give a lecture at the society's annual meeting next year.

15 Oct 2012

vasopharm's explorative phase IIa NOSTRA trial in TBI meets clinical endpoints for safety

vasopharm GmbH, a pharmaceutical company dedicated to the discovery and development of novel therapeutics for the treatment of cerebro- and cardiovascular diseases, today announces that the explorative phase IIa NOSTRA trial in Traumatic Brain Injury Patients met all clinical endpoints for safety and in addition demonstrated strong evidence of clinical benefit in patients.

17 Sep 2012

Link between high tau levels and worse outcome after head trauma

High levels of tau protein in fluid bathing the brain are linked to poor recovery after head trauma, according to a study from Washington University School of Medicine in St. Louis and the Fondazione IRCCS Ca Granda-Ospedale Maggiore Policlinico in Milan, Italy.

14 Dec 2011

UA researchers to study immune response to implanted sensors

A University of Arkansas professor and her colleagues will receive $1.3 million over four years to study the immune response to implanted sensors, such as glucose sensors for diabetics, in hopes of prolonging the life of these important monitoring systems.

13 Oct 2011

PsychoGenics announces alliance with experimental neuropharmacology expert for specialized microdialysis services

PsychoGenics Inc. today announced the establishment of an exclusive alliance with Dr. Jan Kehr, an internationally recognized expert in experimental neuropharmacology, to provide specialized microdialysis services to complement PsychoGenics’ in vivo testing capabilities.

19 Feb 2010

Changes in dopamine levels linked to infant learning patterns

When do you first leave the nest? Early in development infants of many species experience important transitions-such as learning when to leave the protective presence of their mother to start exploring the wider world. Neuroscientists have now pinpointed molecular events occurring in the brain during that turning point.

27 Oct 2009

Chronic sleep deprivation linked to early incidence of Alzheimer's brain plaques

Chronic sleep deprivation in a mouse model of Alzheimer's disease makes Alzheimer's brain plaques appear earlier and more often, researchers at Washington University School of Medicine in St. Louis report online this week in Science Express.

25 Sep 2009

Study focuses on hypertension

How high blood pressure develops and the effects it has on the body are the focus of a two-part study underway at Penn State and Johns Hopkins University that will look at hypertension in the human body and in the laboratory.

17 Sep 2009

Clinical data emphasizing on efficacy and potency of torezolid to be presented

Trius Therapeutics, Inc. announced today that 13 posters will be presented at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) supporting the potency, efficacy and safety of torezolid as a potential new antibiotic for the treatment of severe skin infections caused by gram positive bacteria including MRSA.

14 Sep 2009

Low to moderate drinking releases 'feel-good' endorphins in the brain, not heavy drinking

Scientists know that alcohol affects the brain, but the specifics remain unclear.

20 Mar 2009

Neuron to publish Prana's PBT2 preclinical research on Alzheimer's disease

Prana Biotechnology Ltd. has announced the publication of key research findings with its lead Alzheimer's Disease drug, PBT2.

10 Jul 2008

Researchers close in on origins of main ingredient of Alzheimer's plaques

The ability of brain cells to take in substances from their surface is essential to the production of a key ingredient in Alzheimer's brain plaques, neuroscientists at Washington University School of Medicine in St. Louis have learned.

10 Apr 2008

Blocking stress protein decreases Alzheimer's peptide

Scientists revealed in November 2006 that stress increases production in mice of a brain peptide critical to Alzheimer's disease.

5 Jun 2007

Study shows how ADHD drugs Adderall, Ritalin and Dexedrine work in brain

Although millions depend on medications such as Ritalin to quell symptoms of attention deficit hyperactivity disorder (ADHD), scientists have struggled to pinpoint how the drugs work in the brain.

27 Jun 2006

Brain cell activity influences formation of brain plaque ingredient

Increased communication between brain cells increases levels of amyloid beta, the key ingredient in Alzheimer's brain plaques, scientists at Washington University School of Medicine in St. Louis have found.

22 Dec 2005

Sildenafil restores cognitive function in rats after liver failure

A study involving rats reveals the mechanism responsible for learning impairment due to liver failure and shows that sildenafil restores cognitive function.

19 Jan 2005

Study of the effects of liposuction on different parts of the body finds the procedure to be safe under proper conditions

Researchers at UT Southwestern Medical Center at Dallas have completed the first comprehensive study of the effects of liposuction on different parts of the body during and immediately following the procedure.

2 Sep 2004