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Biomedical, Biophysical and Biological Applications of AFM

An interview with Dr. Thomas Mueller, Director of Product Management at Bruker Nano Surfaces conducted by April Cashin-Garbutt, MA (Cantab).

From Bruker Nano Surfaces and Metrology 10 Jan 2018

General anesthesia may be more complex in its workings than we know now

Associate Professor Bruno van Swinderen from Queensland Brain Institute, University of Queensland with his colleagues have studied the workings of general anesthetics on the brain and found that these agents did more than just put a person to sleep. These findings could pave the way for better and more effective anesthetics they believe. The study was published in the latest issue of the journal Cell Reports.

10 Jan 2018

Choosing The Correct Camera for Fluorescence Microscopy

It is important to select the proper camera for fluorescence microscopy which has high sensitivity and low noise, to avoid photo bleaching your sample. A monochrome camera is also preferred for fluorescence imaging because it does not have a color filter pattern superimposed over the image sensor. Since the microscope’s filter wheel selects which wavelength makes its way to the sensor, a monochrome camera allows equal signal detection on all pixels and increases the overall sensitivity of the camera.

9 Jan 2018

Study identifies how excess fat disrupts heart cells' ability to produce energy

A University of Iowa study has identified how excess fat in the heart, a common feature in diabetes and obesity, can harm the cells' essential ability to produce energy.

5 Jan 2018

Research reveals how Zika virus infection spurs fetal demise

A powerful antiviral protein may act as a checkpoint for keeping or ending a pregnancy.

5 Jan 2018

Researchers use Nobel prize-winning technology to zoom in and see vital kidney protein

Researchers have applied Nobel prize-winning microscope technology to uncover an ion channel structure that could lead to new treatments for kidney stones.

3 Jan 2018

$Common drugs to prevent osteoporotic fractures lead to mineralization of bone cells$

Common drugs to prevent osteoporotic fractures lead to mineralization of bone cells

A study at Sahlgrenska Academy, Sweden, has found that one of the most common medications to prevent osteoporitic fractures gives rise to previously unknown mineralization of bone cells. The discovery may be important for understanding the effect of medication on bone quality.

2 Jan 2018

Scientists unravel structure of protein behind sense of touch

Scientists at The Scripps Research Institute have solved the mystery of the structure of Piezo1, a member of a family of proteins that convert physical stimuli such as touch or blood flow into chemical signals.

21 Dec 2017

Nano-encapsulation of bilirubin could enhance survival rates of pancreatic islet cells

By encapsulating bilirubin within tiny nanoparticles, researchers from North Carolina State University and the Ohio State University have improved the survival rates of pancreatic islet cells in vitro in a low-oxygen environment.

18 Dec 2017

Spatial deconvolution of marker expression in whole heart subjected to ischemia-reperfusion

When a coronary artery is obstructed by atheroma, blood flow is depressed or even arrested. This causes hypoxia of cardiac cells associated with the deprivation of nutrients. In clinic, the first objective is to restore blood flow. However, this is associated with a burst in oxidation of cellular proteins and lipids. This oxidation enhances cell death and participates to the so-called reperfusion injury.

From Logos Biosystems 18 Dec 2017

Belgian researchers create transplantable artificial ovary prototype

Belgian researchers have taken important steps towards creating transplantable artificial ovaries. Once successful, these could be of value to women struggling with infertility or cancer patients who cannot conceive after undergoing radiation or chemotherapy.

13 Dec 2017

Protein structure could pave way for effective drugs to treat cystic fibrosis

Biochemists at the University of Zurich have used cryo-electron microscopy to determine the detailed architecture of the chloride channel TMEM16A. This protein is a promising target for the development of effective drugs to treat cystic fibrosis.

13 Dec 2017

Study provides new insights into development of Sonic Hedgehog medulloblastoma

Medulloblastoma is the most common type of solid brain tumor in children. Current treatments offer limited success and may leave patients with severe neurological side effects, including psychiatric disorders, growth retardation and cognitive impairment.

13 Dec 2017

Live-cell microscopy reveals internal forces that direct cell migration

Two new studies conducted at the Marine Biological Laboratory (MBL) indicate the way by which cells react to internal forces when they orient, gain traction, and migrate in a particular direction.

11 Dec 2017

New small-molecule drug restores brain function, memory in mouse model of Alzheimer's disease

An international team of researchers has shown that a new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease.

5 Dec 2017

Computer simulations provide insights into plasmonic nanovesicles for drug delivery

Imagine a microscopic gold pill that could travel to a specific location in your body and deliver a drug just where it is needed. This is the promise of plasmonic nanovesicles.

1 Dec 2017

Laser techniques could help revolutionize understanding of neurodegenerative diseases

Boulder researchers are embarking on a new project to study the progression of neurodegenerative diseases like Alzheimer's by using a new technique to measure neurons firing deep inside animal brains.

1 Dec 2017

Researchers discover ‘brake’ that interferes with HIV's development into infectious agent

Viewed with a microscope, the virus faintly resembles a pineapple--the universal symbol of welcome. But HIV, the virus that causes AIDS, is anything but that. It has claimed the lives of more than 35 million people so far.

1 Dec 2017

Postnova’s AF2000 FFF system used to unlock mystery of neurodegenerative diseases

Postnova Analytics reports that the Department of Molecular Biology & Biotechnology at the University of Sheffield is using their AF2000 Field Flow Fractionation system to investigate the mechanism of amyloid formation, a protein mis-folding process implicated to be the cause of Alzheimer’s and other neurodegenerative diseases.

From Postnova Analytics 1 Dec 2017

Researchers release open-source dataset offering instructions to build smartphone microscope

Add one more thing to the list of tasks your smartphone can perform. University of Houston researchers have released an open-source dataset offering instructions to people interested in building their own smartphone microscope.

30 Nov 2017

Microscopy News and Research

Biomedical, Biophysical and Biological Applications of AFM

General anesthesia may be more complex in its workings than we know now

Choosing The Correct Camera for Fluorescence Microscopy

Study identifies how excess fat disrupts heart cells' ability to produce energy

Research reveals how Zika virus infection spurs fetal demise

Researchers use Nobel prize-winning technology to zoom in and see vital kidney protein

Common drugs to prevent osteoporotic fractures lead to mineralization of bone cells

Scientists unravel structure of protein behind sense of touch

Nano-encapsulation of bilirubin could enhance survival rates of pancreatic islet cells

Spatial deconvolution of marker expression in whole heart subjected to ischemia-reperfusion

Belgian researchers create transplantable artificial ovary prototype

Protein structure could pave way for effective drugs to treat cystic fibrosis

Study provides new insights into development of Sonic Hedgehog medulloblastoma

Live-cell microscopy reveals internal forces that direct cell migration

New small-molecule drug restores brain function, memory in mouse model of Alzheimer's disease

Computer simulations provide insights into plasmonic nanovesicles for drug delivery

Laser techniques could help revolutionize understanding of neurodegenerative diseases

Researchers discover ‘brake’ that interferes with HIV's development into infectious agent

Postnova’s AF2000 FFF system used to unlock mystery of neurodegenerative diseases

Researchers release open-source dataset offering instructions to build smartphone microscope

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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