Mitosis News and Research

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Protein enzyme BubR1 provides new understanding of processes behind cancer-cell survival and drug-resistance

A study of how one protein enzyme, BubR1, helps make sure chromosomes are equally distributed during mitosis might explain how the process of cell division goes so awry in cancer, according to researchers from Fox Chase Cancer Center.

17 Nov 2008

Researchers show how new chemotherapy drugs kill cancerous tumors

Dr Stephen Taylor and Karen Gascoigne at the University of Manchester's Faculty of Life Sciences have taken a new systematic approach to studying anti-mitotic drugs, which are used extensively for breast or ovarian cancer in the UK.

From The University of Manchester 6 Aug 2008

Discovery of vital key to cancer

University of Manchester scientists have uncovered the 3D structure of Mps1 - a protein that regulates the number of chromosomes during cell division and thus has an essential role in the prevention of cancer - which will lead to the design of safer and more effective therapies.

From The University of Manchester 6 Aug 2008

Dividing cells find their middle by following a protein contour map

Self-organization keeps schools of fish, flocks of birds and colonies of termites in sync. It's also, according to new research, the way cells regulate the final stage of cell division. Scientists at Rockefeller University have shown that a protein-chemistry-based contour map, which helps individual proteins locate the center of their cell without direction from a 'master organizer,' is key to ensuring accurate division during mitosis.

30 Jun 2008

European researchers take lid off the genome

European researchers have made significant progress unravelling how genes are governed and why this sometimes goes wrong in disease.

15 Jun 2008

EntreMed receives new patent for 2-Methoxyestradiol analogs

EntreMed, Inc. has announced the issuance of U.S. Patent No. 7,371,741 covering analogs of 2- methoxyestradiol (2ME2).

11 Jun 2008

New key mechanism in cell division discovered

Scientists at the IFOM-IEO Campus have revealed the function of a protein that is indispensable for passing on an accurate copy of the genome from mother to daughter cells. This study, published in Cell, opens up new avenues of research to reduce the toxicity of chemotherapy in the treatment of cancer.

8 May 2008

Mitosis gets harder thanks to new gene discovery

A biological process taught to every pupil studying science at high school has just become a little more complicated thanks to a new discovery published today.

4 Apr 2008

Smoking's effects on genes may play a role in lung cancer development and survival

Smoking plays a role in lung cancer development, and now scientists have shown that smoking also affects the way genes are expressed, leading to alterations in cell division and regulation of immune response.

21 Feb 2008

Researchers unravel mystery of cell division

Experts in mitosis (cell division) at the University of Virginia Health System have made discoveries that explain how one protein the kinase Aurora B could have such a large role in guiding and policing the process of cell division.

25 Jan 2008

Cell division studies hint at future cancer therapy

When a cell's assets get divided between daughter cells, Dr. Quansheng Du wants to make sure both offspring do well.

23 Jan 2008

How molecular muscles help cells divide

Time-lapse videos and computer simulations provide the first concrete molecular explanation of how a cell flexes tiny muscle-like structures to pinch itself into two daughter cells at the end of each cell division, according to a report in Science Express.

17 Dec 2007

Potent inhibitor of Kinesin CENP-E demonstrates tumor cell inhibition

A first-in-class, targeted investigational therapy specifically designed to inhibit a single protein that functions only during cell division shows potent activity in a broad range of cancer cell lines, say researchers from GlaxoSmithKline.

24 Oct 2007

Experimental cancer pharmaceuticals under trial

A potent and selective inhibitor of the mitotic kinesin CENP-E (GSK923295A) demonstrates a novel mechanism of inhibiting tumor cell proliferation and shows activity against a broad panel of human tumor cell lines in vitro: Abstract A 111.

24 Oct 2007

Transgenics sped up

A new method of constructing artificial plant chromosomes from small rings of naturally occurring plant DNA can be used to transport multiple genes at once into embryonic plants where they are expressed, duplicated as plant cells divide, and passed on to the next generation -- a long-term goal for those interested in improving agricultural productivity.

19 Oct 2007

Clearer picture of how a dividing cell rebuilds the nuclear envelope

Just how a dividing cell rebuilds the nuclear envelope, the protective, functional wrapping that encases both the original and newly copied genetic material, has been a source of controversy for the last 20 years.

10 Sep 2007

Researchers dispute immortal strand hypothesis

How do adult stem cells protect themselves from accumulating genetic mutations that can lead to cancer?

30 Aug 2007

Scientists discover how HIV/AIDS disrupts the normal replication of stem cells in the adult brain

A prominent problem in AIDS is a form of dementia that robs one's ability to concentrate and perform normal movements.

17 Aug 2007

Link between ciliary signaling and cancer

Submarines have periscopes. Insects have antennae. And increasingly, biologists are finding that most normal vertebrate cells have cilia, small hair-like structures that protrude like antennae into the surrounding environment to detect signals that control cell growth.

29 Jun 2007

New anti-cancer target in enzyme MAP4K3

Scientists working at the Institute for Cancer Research have found a new anti-cancer target in MAP4K3, an enzyme which is able to 'switch on' the growth-promoter mTOR.

14 Mar 2007