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New drug candidates show promise to reverse HIV immune evasion

University of Pittsburgh School of Medicine scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.

19 Mar 2024

Research unveils a cellular shield against harmful effects of UV-induced RNA damage

UV radiation in the sunlight causes sunburn and increases the risk of skin cancer by damaging our DNA but also our RNA.

18 Mar 2024

Lab-synthesized heparin to transform drug manufacturing

Heparin, the world's most widely used blood thinner, is used during procedures ranging from kidney dialysis to open heart surgery.

18 Mar 2024

Study reveals the inner workings of gene mutations linked to ultra-rare syndrome

A team from the University of Ottawa's Faculty of Medicine has completed an exciting new study that reveals the inner workings of gene mutations that result in an ultra-rare syndrome with fewer than 100 reported cases since its first description in the early 1960s.

18 Mar 2024

Unlocking weight loss through exercise mimicry with metformin

An "anti-hunger" molecule produced after vigorous exercise is responsible for the moderate weight loss caused by the diabetes medication metformin, according to a new study in mice and humans.

18 Mar 2024

Synthetic mucins shed light on cancer biology and tumor formation

During cold and flu season, excess mucus is a common, unpleasant symptom of illness, but the slippery substance is essential to human health.

18 Mar 2024

Arrayjet’s ArrayPlex platform selected by Immunome for use in its discovery of targeted cancer therapies

Immunome signs deal to use Arrayjet platform in its in-house screening operations.

From Arrayjet Ltd 18 Mar 2024

Scientists aim to understand why T cells do not sustain energy in tumors

T cells are often called "assassins" or "killers" because they can orchestrate and carry out missions to hunt down bacteria, viruses, and cancer cells throughout the body.

15 Mar 2024

BU study reveals key to combating high-risk neuroblastoma

The MYCN oncoprotein (proteins related to the growth of cancer cells) plays a key role in starting, advancing and making it difficult to treat various human cancers.

15 Mar 2024

Researchers pioneer a novel approach to enhance diabetic wound healing

Researchers unveiled a novel therapy for diabetic wound healing. This research highlights the use of exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells (BMSCs) to significantly enhance wound healing by promoting keratinocyte autophagy.

14 Mar 2024

Researchers shed light on cancer cell survival in early hypoxia

Researchers at the Francis Crick Institute have shed light on how cancer cells survive in the first few hours after being cut off from a supply of oxygen.

14 Mar 2024

Innovative diagnostic platform uses sound waves for exosome-based disease detection

Mechanical engineers at Duke University have devised a new type of diagnostic platform that uses sound waves to spin an individual drop of water up to 6,000 revolutions per minute.

13 Mar 2024

LGM Pharma unveils enhanced analytical testing services and expands CDMO portfolio with additional suppository manufacturing capabilities

LGM Pharma, a leading provider of tailored API and CDMO services for the full drug product lifecycle, today announced a significant enhancement of its capabilities: a 50% expansion and an investment exceeding $2 million in its standalone offering for Analytical Testing Services (ATS) alongside the introduction of new suppository manufacturing capabilities to its contract development and manufacturing (CDMO) portfolio.

From LGM Pharma 13 Mar 2024

New custom-designed proteins can efficiently reach intramembrane targets

Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, Scripps Research chemists have demonstrated new custom-designed proteins that can efficiently reach these "intramembrane" targets.

13 Mar 2024

Molecular Rosetta stone provides previously unknown insight into gut microbiome communication

Researchers from Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have uncovered thousands of previously unknown bile acids, a type of molecule used by our gut microbiome to communicate with the rest of the body.

12 Mar 2024

Exploristics and Exonate announce successful collaboration to enhance clinical trial study design using cloud-based simulation

Exploristics’ cloud-based simulation platform KerusCloud used to enhance study design for Exonate’s upcoming Phase IIb study following successful Phase Ib/IIa study.

12 Mar 2024

Molecule News and Research

New drug candidates show promise to reverse HIV immune evasion

Research unveils a cellular shield against harmful effects of UV-induced RNA damage

Lab-synthesized heparin to transform drug manufacturing

Study reveals the inner workings of gene mutations linked to ultra-rare syndrome

Unlocking weight loss through exercise mimicry with metformin

Synthetic mucins shed light on cancer biology and tumor formation

Arrayjet’s ArrayPlex platform selected by Immunome for use in its discovery of targeted cancer therapies

Scientists aim to understand why T cells do not sustain energy in tumors

BU study reveals key to combating high-risk neuroblastoma

Researchers pioneer a novel approach to enhance diabetic wound healing

Researchers shed light on cancer cell survival in early hypoxia

Innovative diagnostic platform uses sound waves for exosome-based disease detection

LGM Pharma unveils enhanced analytical testing services and expands CDMO portfolio with additional suppository manufacturing capabilities

New custom-designed proteins can efficiently reach intramembrane targets

Molecular Rosetta stone provides previously unknown insight into gut microbiome communication

Exploristics and Exonate announce successful collaboration to enhance clinical trial study design using cloud-based simulation

New “GPS nanoparticle” delivers a genetic punch to the protein implicated in tumor spread

LAG-3 protein structure may be the key to unlocking new cancer treatments

Study highlights potential therapeutic target for immune-related disorders

Researchers forge new path to combat viruses and cancers with helicase inhibitors

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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