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INTEGRA Biosciences’ pipettes help progress small molecule inhibitors from discovery to clinical trials

RAPT Therapeutics in San Francisco, USA, relies on INTEGRA Biosciences’ pipettes to seamlessly accelerate the development of its candidate small molecule inhibitors for the treatment of inflammatory diseases and cancers.

From INTEGRA Biosciences 22 Oct 2024

Optibrium demonstrates superior molecular docking method for small molecules and macrocycles

Optibrium, a leading developer of software and AI solutions for molecular design today announced the publication of a peer-reviewed study in the Journal of Computer-Aided Molecular Design, 'Structure-Based Pose Prediction: Non-cognate Docking Extended to Macrocylic Ligands'.

From Optibrium Ltd. 22 Oct 2024

New antibody targets cancer-causing HER2 mutations

For some proteins, a single mutation, or change in its DNA instructions, is all it takes to tip the balance between functioning normally and causing cancer.

22 Oct 2024

New CAR T cells offer controlled treatment for solid tumors

Ludwig Cancer Research scientists have devised new types of chimeric antigen-receptor (CAR) T cells-;a type of cancer immunotherapy-;that can be switched on to varying degrees of intensity and then switched off on demand with existing drugs.

21 Oct 2024

New PET scan effectively detects benign insulinomas in the pancreas

A new PET scan reliably detects benign tumors in the pancreas, according to research led by Radboud university medical center.

21 Oct 2024

Scientists reveal how miRNAs shape cancer and offer new paths for treatment

Review explores how microRNAs (miRNAs) interact in cancer development, their potential in diagnosis, and innovative therapeutic strategies, including overcoming chemotherapy resistance.

20 Oct 2024

The molecular underpinnings by which traumatic brain injury increases Alzheimer's disease risk

Findings indicate BAG3 modulation after traumatic brain injury may mitigate tau buildup and cognitive deficits, presenting a target for Alzheimer's prevention.

18 Oct 2024

Ubiquigent partners with Alleo Labs to advance DUB-targeting therapies

Ubiquigent Limited (“Ubiquigent”), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, today announced a strategic partnership with Alleo Labs Corp. (“Alleo”), a pioneer in using artificial intelligence (AI) to develop new therapeutics for neurological diseases.

18 Oct 2024

Researchers uncover the potential of JAK inhibitors to treat life-threatening skin disease

Researchers identified Janus kinase inhibitors as a promising treatment for the severe drug-induced skin condition toxic epidermal necrolysis, by analyzing patient biopsies with deep visual proteomics.

17 Oct 2024

New compounds from fungi show promise in treating colorectal cancer

Novel chemical compounds from a fungus could provide new perspectives for treating colorectal cancer, one of the most common and deadliest cancers worldwide.

17 Oct 2024

New synthesis technology promises faster production of mRNA vaccines

In an era where viral outbreaks can escalate into global pandemics with alarming speed, the ability to quickly develop new vaccines has become crucial.

17 Oct 2024

Structural biology uncovers the molecular basis of b1 vitamin transport and deficiency

Vitamin B1, also known as thiamine, is essential for the survival of our cells. The human body can't produce it, but we can maintain healthy levels of this vitamin by eating foods like salmon, legumes, and brown rice.

16 Oct 2024

Alleo and Ubiquigent enter AI-driven strategic partnership to accelerate DUB-focused drug discovery

From Ubiquigent Limited 16 Oct 2024

Harnessing the power of miRNA for cancer diagnosis and treatment

This study is led by Dr. Shiwei Duan (Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, China). His team analyzed literature on miRNA, summarizing the close relationship between these small molecules and cancer. miRNA is a type of non-coding RNA that does not encode proteins, but can target more than 60% of human protein-coding genes.

15 Oct 2024

Scripps Research identifies binding site on challenging cancer protein

Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types of cancers to grow and proliferate.

15 Oct 2024

Emory University researchers shift focus to neuroinflammation in Alzheimer's treatment

For decades, Alzheimer's research has focused on examining amyloid plaques in the brain and prescribing antibody therapeutics that remove the plaques to slow cognitive decline in patients.

15 Oct 2024

Semaglutide enhances cognitive abilities and reduces Alzheimer’s pathology in mice and human brain models

Researchers find that Semaglutide improves cognitive function and reduces amyloid and tau pathology in Alzheimer's disease models, while restoring oxytocin levels in both mice and human brain organoids.

14 Oct 2024

A novel approach to understanding protein compartmentalization

In physics, a system composed of two substances can be modeled in accordance with classical mixture theory, which considers the fraction corresponding to each constituent and the interactions among constituents. Examples include the coexistence of high- and low-density phases in supercooled water and the coexistence of metal puddles in an insulating matrix in the Mott metal-insulator transition.

14 Oct 2024

New insights on protein degraders open doors to treatment for 'undruggable' diseases

Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called 'protein degraders' which can be deployed to combat what have previously been regarded as 'undruggable' diseases, including cancers and neurodegenerative diseases.

12 Oct 2024

New insights into stem cell control in plant meristems

Researchers from the University of Freiburg have identified the HAN molecule as an important regulator that controls plant growth in conjunction with WOX5.

12 Oct 2024

Molecule News and Research

INTEGRA Biosciences’ pipettes help progress small molecule inhibitors from discovery to clinical trials

Optibrium demonstrates superior molecular docking method for small molecules and macrocycles

New antibody targets cancer-causing HER2 mutations

New CAR T cells offer controlled treatment for solid tumors

New PET scan effectively detects benign insulinomas in the pancreas

Scientists reveal how miRNAs shape cancer and offer new paths for treatment

The molecular underpinnings by which traumatic brain injury increases Alzheimer's disease risk

Ubiquigent partners with Alleo Labs to advance DUB-targeting therapies

Researchers uncover the potential of JAK inhibitors to treat life-threatening skin disease

New compounds from fungi show promise in treating colorectal cancer

New synthesis technology promises faster production of mRNA vaccines

Structural biology uncovers the molecular basis of b1 vitamin transport and deficiency

Alleo and Ubiquigent enter AI-driven strategic partnership to accelerate DUB-focused drug discovery

Harnessing the power of miRNA for cancer diagnosis and treatment

Scripps Research identifies binding site on challenging cancer protein

Emory University researchers shift focus to neuroinflammation in Alzheimer's treatment

Semaglutide enhances cognitive abilities and reduces Alzheimer’s pathology in mice and human brain models

A novel approach to understanding protein compartmentalization

New insights on protein degraders open doors to treatment for 'undruggable' diseases

New insights into stem cell control in plant meristems

A new way of characterising biomolecules eBook

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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