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Rigel plans to focus on completing three clinical programs for ITP, DLE and dry eye disease

Rigel Pharmaceuticals, Inc. today announced its plans to focus the Company's resources on the completion of three lead clinical programs. These efforts include commencing a Phase 3 clinical study of fostamatinib, an oral SYK inhibitor, in Immune Thrombocytopenic Purpura pending discussions with regulatory agencies.

5 Sep 2013

Case Western researchers establish Kruppel-like factors as master regulators of vascular health

Case Western Reserve researchers have identified a genetic factor that blocks the blood vessel inflammation that can lead to heart attacks, strokes and other potentially life-threatening events.

5 Sep 2013

Parkin protein plays key role in destruction of bacteria that cause tuberculosis

A protein at the center of Parkinson's disease research now also has been found to play a key role in causing the destruction of bacteria that cause tuberculosis, according to scientists led by UC San Francisco microbiologist and tuberculosis expert Jeffery Cox, PhD.

5 Sep 2013

Repligen Earns $1M Pfizer Milestone Payment

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4 Sep 2013

Study identifies new tool to accurately analyze mtDNA deletions associated with diseases, aging

A study published today in Aging Cell identifies a new tool to accurately analyze extremely rare mitochondrial DNA deletions associated with a range of diseases and disorders as well as aging. This approach, which relies on Droplet Digital PCR (ddPCR-) technology, will help researchers explore mtDNA deletions as potential disease biomarkers.

4 Sep 2013

65 metabolites in urine simultaneously measured by clinical IEM-by-NMR screening study in Turkey

At the 12th International Congress of Inborn Errors of Metabolism (www.iciem2013.com), Bruker announces another milestone in the cost-effective use of NMR (nuclear magnetic resonance) spectroscopy screening as a clinical research tool for metabolic screening and small molecule in vitro diagnostics (IVD) research and validation.

4 Sep 2013

Precisely designed macromolecule mimics binding of HIV to immune system cells

A precisely designed macromolecule that mimics the binding of HIV to immune system cells could be used to stop the virus from physically entering the body, according to a new study led by a materials scientist at Queen Mary University of London.

4 Sep 2013

Researchers discover new way to target senescent cancer cells for destruction

Resting cancer cells can be selectively destroyed by inhibiting their energy metabolism. This is the recent discovery by researchers at Charité Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine (MDC) in Berlin-Buch, together with other cooperation partners from Germany. The findings of their study have been published in the scientific journal Nature.

4 Sep 2013

Researchers identify role played by protein in controlling brain activity during seizure

People with epilepsy could be helped by new research into the way a key molecule controls brain activity during a seizure. Researchers have identified the role played by of a protein - called BDNF - and say the discovery could lead to new drugs that calm the symptoms of epileptic seizures.

4 Sep 2013

Argininosuccinic aciduria (ASA) and gene therapy: an interview with Dr Julien Baruteau, UCL Institute for Women's Health, London

This rare genetic condition can theoretically affect patients at any age but symptoms are more often observed in childhood and even uncommonly during the first days of life.

2 Sep 2013

Nanostructures made of DNA strands can encapsulate, release small-molecule drugs

Nanoscale "cages" made from strands of DNA can encapsulate small-molecule drugs and release them in response to a specific stimulus, McGill University researchers report in a new study.

2 Sep 2013

Small chemical changes to dietary flavonoids cause large effects on human immune system

Scientists at the University of York have discovered that very small chemical changes to dietary flavonoids cause very large effects when the plant natural products are tested for their impact on the human immune system.

31 Aug 2013

GW researcher to receive $1.3M NIDDK grant to study how type 2 diabetes develops

A George Washington University researcher will receive $1.3 million over the next five years from the National Institute of Diabetes and Digestive and Kidney Diseases for research that will help better understand how type 2 diabetes develops, possibly informing the development of novel treatments to reverse the disease.

30 Aug 2013

Researchers discover protein that may help predict breast cancer prognosis

Researchers have identified a protein that they believe may help predict breast cancer prognosis, potentially relieving thousands of women at low risk from having to undergo painful, oft-debilitating therapies, while insuring the most successful treatments for those at high risk. The research was published ahead of print in the journal Molecular and Cellular Biology.

30 Aug 2013

Study explains how sensory input impacts fruit flies' decisions about sweet taste

Fruit flies have a lot to teach us about the complexity of food. Like these tiny little creatures, most animals are attracted to sugar but are deterred from eating it when bitter compounds are added.

29 Aug 2013

Researchers identify possible treatment strategy for ALS and other neurodegenerative disorders

Researchers have tied mutations in a gene that causes amyotrophic lateral sclerosis and other neurodegenerative disorders to the toxic buildup of certain proteins and related molecules in cells, including neurons. The research, published recently in the scientific journal Cell, offers a new approach for developing treatments against these devastating diseases.

29 Aug 2013

Tumor Suppressor May Actually Drive Cancer Development

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28 Aug 2013

New compound offers way to treat migraine and other disorders of central nervous system

For many migraine sufferers, bright lights are a surefire way to exacerbate their headaches. And for some night-shift workers, just a stroll through a brightly lit parking lot during the morning commute home can be enough to throw off their body's daily rhythms and make daytime sleep nearly impossible. But a new molecule that selectively blocks specialized light-sensitive receptors in the eyes could help both these groups of people, without affecting normal vision.

28 Aug 2013

Research finding could lead to potential treatment for lymphedema

The molecule interleukin-7 is an important immune messenger protein which ensures that a sufficient number of T cells are present in our body for immune defence. Researchers from ETH Zurich have now demonstrated that IL-7 has another important function: it enhances the drainage function of lymphatic vessels, which collect fluid that has leaked out of blood vessels into the body tissue and return it to the bloodstream.

27 Aug 2013

UAB study points to protein pathway that could lead to new treatments for diabetes

The same protein tells beta cells in the pancreas to stop making insulin and then to self-destruct as diabetes worsens, according to a University of Alabama at Birmingham study published online today in the journal Nature Medicine.

27 Aug 2013

Molecule News and Research

Rigel plans to focus on completing three clinical programs for ITP, DLE and dry eye disease

Case Western researchers establish Kruppel-like factors as master regulators of vascular health

Parkin protein plays key role in destruction of bacteria that cause tuberculosis

Repligen Earns $1M Pfizer Milestone Payment

Study identifies new tool to accurately analyze mtDNA deletions associated with diseases, aging

65 metabolites in urine simultaneously measured by clinical IEM-by-NMR screening study in Turkey

Precisely designed macromolecule mimics binding of HIV to immune system cells

Researchers discover new way to target senescent cancer cells for destruction

Researchers identify role played by protein in controlling brain activity during seizure

Argininosuccinic aciduria (ASA) and gene therapy: an interview with Dr Julien Baruteau, UCL Institute for Women's Health, London

Nanostructures made of DNA strands can encapsulate, release small-molecule drugs

Small chemical changes to dietary flavonoids cause large effects on human immune system

GW researcher to receive $1.3M NIDDK grant to study how type 2 diabetes develops

Researchers discover protein that may help predict breast cancer prognosis

Study explains how sensory input impacts fruit flies' decisions about sweet taste

Researchers identify possible treatment strategy for ALS and other neurodegenerative disorders

Tumor Suppressor May Actually Drive Cancer Development

New compound offers way to treat migraine and other disorders of central nervous system

Research finding could lead to potential treatment for lymphedema

UAB study points to protein pathway that could lead to new treatments for diabetes

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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