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IBM scientists image the anantomy of a molecule using noncontact atomic force microscopy

IBM scientists have been able to image the "anatomy" -- or chemical structure -- inside a molecule with unprecedented resolution, using a complex technique known as noncontact atomic force microscopy.

28 Aug 2009

$11.5 million grant to Mayo Clinic Cancer Center to translate research into treatments for women with ovarian cancer

Investigators at the Mayo Clinic Cancer Center have received a five-year, $11.5 million grant to translate research into treatments for women with ovarian cancer.

28 Aug 2009

Arno Therapeutics to commence Phase 1 clinical study of AR-12 in adult patients with lymphoma

Arno Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on oncology therapeutics, today announced the dosing of the first patient in a Phase I clinical study of AR-12 (formerly OSU-03012) in adult patients with advanced or recurrent solid tumors or lymphoma.

28 Aug 2009

Fatostatin lowers the activity of genes associated with cholesterol synthesis

A small molecule earlier found to have both anti-fat and anti-cancer abilities works as a literal turnoff for fat-making genes, according to a new report in the August 28th issue of the journal Chemistry and Biology, a Cell Press journal.

27 Aug 2009

Fluidigm manufactures more than 250 million microscopic NanoFlex valves at its Singapore biochip factory

Fluidigm today announced that its Singapore biochip factory has manufactured and shipped more than 250 million microscopic NanoFlex™ valves. The 250 million valves built into Fluidigm’s integrated fluidic circuits (IFCs) would be equivalent to the number of valves required for all the conventional plumbing – both residential and commercial – in a metropolitan region the size of the San Francisco Bay Area.

27 Aug 2009

Researchers devise a live cell morphological profiling approach using the xCELLigence RTCA System

The extent to which protein targets are modulated by drugs or small molecule compounds depends on a number of factors, including the expression levels of the target, the effective concentration of the compound, and the time needed for the compound to perturb the target. To address these restrictions, researchers Abassi et al. (1) have devised a live cell morphological profiling approach for dynamic monitoring of the effect of small molecule compounds that was based on impedance measurement of cells with the xCELLigence RTCA System of Roche Applied Science.

27 Aug 2009

UT Southwestern awarded $763,000 as grant to expand studies of Peregrine's anti-PS antibodies

Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM) today announced that the U.S. National Institute of Allergy and Infectious Diseases (NIAID) has awarded a two-year, $763,000 grant to Philip Thorpe, Ph.D., of the University of Texas Southwestern Medical Center for research expanding its studies of anti-phosphatidylserine (anti-PS) antibodies as potential treatments for viral hemorrhagic fever (VHF) infections.

26 Aug 2009

EPIX Pharmaceuticals' PRX-00023 Therapeutics CNS program in Phase 2B/3 offered for auction sale

Joseph F. Finn, Jr., C.P.A. ("Finn"), announced today that the PRX-00023 Therapeutics Program in Phase 2b/3 will be part of the intellectual property offered for sale at the September 30, 2009 auction.

26 Aug 2009

SIRO Clinpharm and CambReg Regulatory Services announces their alliance

SIRO Clinpharm, a leading Indian MNC CRO, and CambReg Regulatory Services, a UK-based pan-European regulatory services provider, announced today the formation of an exclusive strategic alliance to help companies register their products in the European market.

26 Aug 2009

Study suggests that connective tissue growth factor plays a vital role in liver fibrosis progression

Accumulating evidence suggests that connective tissue growth factor (CCN2) plays a central role in fibrotic conditions in many organ systems. Fibrosis is a scarring condition that is characterized by excessive collagen production that impedes normal cell function and can cause organ dysfunction and failure.

25 Aug 2009

Primary cilia can suppress or promote skin cancer

Tiny, solitary spikes that stick out of nearly every cell in the body play a central role in a type of skin cancer, new research has found. The discovery in mice shows that the microscopic structures known as primary cilia can either suppress or promote this skin cancer, depending on the mutation triggering the disease.

24 Aug 2009

Microbiologists discover new therapies for human respiratory syncytial virus and influenza A virus

A cellular molecule that not only can sense two common respiratory viruses but also can direct cells to mount a defense has been identified by microbiologists at The University of Texas Health Science Center at San Antonio.

24 Aug 2009

Ron Demuth of ChemDiv announces extension of collaboration with Lilly

ChemDiv, Inc. announced the expansion of its drug discovery collaboration with Eli Lilly through 2010. Under the terms of the agreement, the partners will identify and develop leads for an additional therapeutic target using ChemDiv's small molecule resources (the industry's largest commercial collection) and Discovery outSource™ drug discovery and development platforms.

21 Aug 2009

Lonza submits non-binding proposal to buy all of outstanding restricted voting shares of Patheon

The Special Committee of Independent Directors of Patheon Inc. (TSX:PTI) and Lonza Group AG (SIX:LONN) announced today that Lonza, one of the world's leading suppliers to the pharmaceutical, healthcare and life science industries, has submitted a non-binding proposal to acquire all of the outstanding Restricted Voting Shares of Patheon at a price of US$3.55 per Restricted Voting Share.

21 Aug 2009

Researchers develop new ways for splitting dangerous pair of cancer proteins

A research team led by U of T Mississauga scientists has developed a new way to split up a dangerous pair of cancer proteins, a finding that could ultimately lead to chemotherapy that is more effective and has fewer side effects.

21 Aug 2009

Helicos Genetic Analysis System to aid Ontario Institute for Cancer Research scientists in the study of cancer genomics

Helicos BioSciences Corporation (NASDAQ: HLCS), a life science company focused on innovative genetic analysis technologies, today announced the placement of a Helicos™ Genetic Analysis System at the Ontario Institute for Cancer Research (OICR) with Drs. Tom Hudson and John McPherson.

20 Aug 2009

Shape-changing in proteins opens new avenue for drug discovery

Computational biologists at the University of Pittsburgh School of Medicine have shown that proteins have an intrinsic ability to change shape, and this is required for their biological activity. This shape-changing also allows the small molecules that are attracted to a given protein to select the structure that permits the best binding. That premise could help in drug discovery and in designing compounds that will have the most impact on protein function to better treat a host of diseases.

20 Aug 2009

New strategy found to increase the efficacy of protein-based drugs

A new method for attaching a large protective polymer molecule to a protein appears to improve protein drugs significantly.

20 Aug 2009

Inovio Biomedical records $2.9 million revenues in the six months ended June 30, 2009

Inovio Biomedical Corporation (NYSE AMEX: INO) (“Inovio”) today reported financial results for the three and six months ended June 30, 2009. Total revenue of $2.5 million and $2.9 million for the three and six months ended June 30, 2009, compared to $663,000 and $1.3 million for the three and six months ended June 30, 2008, respectively.

20 Aug 2009

Vanderbilt enters Chemical Biology Consortium as a Chemical Diversity Center to develop cancer treatment drugs

Vanderbilt University has been selected as one of 10 centers in the nation to participate in the Chemical Biology Consortium (CBC), a major new initiative to facilitate the discovery and development of new agents to treat cancer.

20 Aug 2009

Molecule News and Research

IBM scientists image the anantomy of a molecule using noncontact atomic force microscopy

$11.5 million grant to Mayo Clinic Cancer Center to translate research into treatments for women with ovarian cancer

Arno Therapeutics to commence Phase 1 clinical study of AR-12 in adult patients with lymphoma

Fatostatin lowers the activity of genes associated with cholesterol synthesis

Fluidigm manufactures more than 250 million microscopic NanoFlex valves at its Singapore biochip factory

Researchers devise a live cell morphological profiling approach using the xCELLigence RTCA System

UT Southwestern awarded $763,000 as grant to expand studies of Peregrine's anti-PS antibodies

EPIX Pharmaceuticals' PRX-00023 Therapeutics CNS program in Phase 2B/3 offered for auction sale

SIRO Clinpharm and CambReg Regulatory Services announces their alliance

Study suggests that connective tissue growth factor plays a vital role in liver fibrosis progression

Primary cilia can suppress or promote skin cancer

Microbiologists discover new therapies for human respiratory syncytial virus and influenza A virus

Ron Demuth of ChemDiv announces extension of collaboration with Lilly

Lonza submits non-binding proposal to buy all of outstanding restricted voting shares of Patheon

Researchers develop new ways for splitting dangerous pair of cancer proteins

Helicos Genetic Analysis System to aid Ontario Institute for Cancer Research scientists in the study of cancer genomics

Shape-changing in proteins opens new avenue for drug discovery

New strategy found to increase the efficacy of protein-based drugs

Inovio Biomedical records $2.9 million revenues in the six months ended June 30, 2009

Vanderbilt enters Chemical Biology Consortium as a Chemical Diversity Center to develop cancer treatment drugs

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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