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UT Southwestern scientists identify genetic mutations that contribute to nonalcoholic fatty liver disease

Using a genetic screening platform developed by a UT Southwestern Nobel Laureate, scientists with the Center for the Genetics of Host Defense at UT Southwestern Medical Center have identified genetic mutations that contribute to nonalcoholic fatty liver disease (NAFLD), providing a potential future target for therapeutic interventions.

9 Sep 2022

All SARS-CoV-2 variants neutralized by a potent new antibody

Researchers describe a mouse model used to generate a VH1-2 heavy chain (HC)- and Vκ1-33 light chain (LC)-based recombinant antibody that broadly neutralized all severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including the newly emergent Omicron sub-variant BA.5.

9 Sep 2022

New agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease

A newly developed agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease, signaling its promise as a potential treatment for the disease, according to a team of researchers at UTHealth Houston.

8 Sep 2022

The role of nasal microbiome in Parkinson's disease

A recent study provides an overview of how the nasal bacterial population influences olfactory processing and neurodegeneration.

5 Sep 2022

Study sheds light on how seasonal changes in day length alter the brain and subsequent behavior

Seasonal changes in light -; longer days in summer, shorter in winter -; have long been associated with human behaviors, affecting everything from sleep and eating patterns to brain and hormonal activity.

2 Sep 2022

Research reveals a starring role for mitochondrial dynamics within adult muscle stem cells

Mitochondria are remarkable shape-shifting organelles that have long been understood as the powerhouses inside our cells.

2 Sep 2022

GnRH therapy could improve cognitive deficits in men with Down syndrome

Gonadotropin-releasing hormone (GnRH) therapy improves cognitive function in Down syndrome (DS) mouse models and male patients with DS, according to a new study.

1 Sep 2022

Early therapeutic interventions may be effective in treating Fragile X Syndrome

A new study suggests that therapeutic interventions to treat neurodevelopmental disorders may be more effective if done during the early stages of brain development.

1 Sep 2022

Molecular fate-mapping of antibodies shows effects of antigenic imprinting

In a new study, researchers developed a molecular fate-mapping method for differential detection of antibodies derived from specific B cell clones.

1 Sep 2022

New treatment may be effective in addressing the long-term effects of preeclampsia

Preeclampsia is a condition that affects the placenta during pregnancy and is dangerous for both the fetus and the mother.

30 Aug 2022

Researchers create first mouse model carrying a disease-associated mitochondrial mutation

Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models with the necessary mitochondrial mutations to observe these tiny organelles.

30 Aug 2022

Single mutation in Kcnc3 gene causes learning deficits in mice

A single mutation in a gene, Kcnc3, which encodes a potassium channel in neurons, causes learning deficits in mice, UT Southwestern researchers report in a new study in PNAS.

29 Aug 2022

Researchers identify a potential new therapeutic approach to fight angioimmunoblastic T-cell lymphoma

A type of blood cell cancer called angioimmunoblastic T-cell lymphoma (AITL) can develop as mutations accumulate with age in the stem cells from which the T cells in the blood develop.

24 Aug 2022

Modified TB vaccine could help treat non-muscle invasive bladder cancer

A modified tuberculosis (TB) vaccine developed at Texas Biomed could help treat a form of bladder cancer, called non-muscle invasive bladder cancer, without strong side effects.

22 Aug 2022

“Drug factory” implants show promise in eradicating mesothelioma tumors

Rice University and Baylor College of Medicine researchers have shown they can eradicate advanced-stage mesothelioma tumors in mice in just a few days with a treatment combining Rice's cytokine "drug factory" implants and a checkpoint inhibitor drug.

22 Aug 2022

New treatment may help counteract food allergies and inflammatory diseases in future

Although many people with dietary allergies experience mild symptoms when exposed to triggering foods, some face potentially fatal consequences.

22 Aug 2022

Researchers report the effects of a common Japanese herbal remedy on colitis

Zhengzheng Shi and colleagues at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan report the effects of a common herbal remedy on colitis, one of two conditions that comprise inflammatory bowel disease (IBD).

18 Aug 2022

Novel member of a class of anti-diabetes drugs could help treat muscle wasting disease

Inflammatory myopathies can be challenging to treat, but a new study reports encouraging findings for patients with these debilitating conditions. Researchers from Japan have found that a novel member of a class of anti-diabetes drugs could be the key to treating patients with muscle wasting disease.

18 Aug 2022

Therapeutic target for several metabolic diseases may help fight Alzheimer’s disease

In the recent popular Korean TV series "The Light in Your Eyes," many viewers emphasized with the main character suffering from Alzheimer's disease.

18 Aug 2022

CD98 identified as a key mediator of pro-fibrotic and acute inflammatory responses in the lung

Researchers investigated the role of the CD98 glycoprotein in inducing an inflammatory response to SARS-CoV-2 in patients of progressive fibrosis interstitial lung diseases, including the archetypal PFILD, idiopathic pulmonary fibrosis.

18 Aug 2022

Mouse Model News and Research

UT Southwestern scientists identify genetic mutations that contribute to nonalcoholic fatty liver disease

All SARS-CoV-2 variants neutralized by a potent new antibody

New agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease

The role of nasal microbiome in Parkinson's disease

Study sheds light on how seasonal changes in day length alter the brain and subsequent behavior

Research reveals a starring role for mitochondrial dynamics within adult muscle stem cells

GnRH therapy could improve cognitive deficits in men with Down syndrome

Early therapeutic interventions may be effective in treating Fragile X Syndrome

Molecular fate-mapping of antibodies shows effects of antigenic imprinting

New treatment may be effective in addressing the long-term effects of preeclampsia

Researchers create first mouse model carrying a disease-associated mitochondrial mutation

Single mutation in Kcnc3 gene causes learning deficits in mice

Researchers identify a potential new therapeutic approach to fight angioimmunoblastic T-cell lymphoma

Modified TB vaccine could help treat non-muscle invasive bladder cancer

“Drug factory” implants show promise in eradicating mesothelioma tumors

New treatment may help counteract food allergies and inflammatory diseases in future

Researchers report the effects of a common Japanese herbal remedy on colitis

Novel member of a class of anti-diabetes drugs could help treat muscle wasting disease

Therapeutic target for several metabolic diseases may help fight Alzheimer’s disease

CD98 identified as a key mediator of pro-fibrotic and acute inflammatory responses in the lung

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