Mouse Model News and Research

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Effectiveness of Lactobacillus in treating inflammatory bowel disease

The role of Lactobacillus in treating inflammatory bowel disease.

4 Oct 2023

Trametinib: Potential therapeutic game-changer for Alzheimer's disease

Researchers developed the ATRIVIEW® platform to screen for molecules that promote differentiation neural stem cells (NSCs).

4 Oct 2023

New discovery could delay relapse in triple-negative breast cancer

A team of researchers at the Medical University of Vienna has discovered that dormant tumor cells surviving chemotherapy can be targeted through the inhibition of a specific protein called P-glycoprotein (P-gp).

3 Oct 2023

Researchers discover how Zika virus persists in the placenta

Before SARS-CoV-2 and the COVID-19 pandemic, there was the Zika virus epidemic, lasting from 2015 to 2016. The Zika virus can cause serious birth defects and abnormalities.

26 Sep 2023

Engineered mice reveal how Omicron subvariant BA.5 is more virulent

New research used engineered mice to compare SARS-COV-2 omicron subvariants and found one of them – BA.5 – was more virulent likely due to its ability to rapidly replicate early during infection.

25 Sep 2023

New model paves way to understanding and preventing SUDEP in familial epilepsy

Researchers at the University of Michigan have developed a model for studying one type of familial epilepsy, opening the door to understanding—and eventually targeting—the mechanisms that lead to the disorder and its associated fatalities.

25 Sep 2023

Peptide vaccine targets H3K27M mutation in midline gliomas, shows promise in early trials

Tumor vaccines can help the body fight cancer. These vaccines alert the patient's immune system to proteins that are carrying cancer-typical alterations.

22 Sep 2023

Scientists uncover a crucial component for restoring functional activity after spinal cord injury

In a new study in mice, a team of researchers from UCLA, the Swiss Federal Institute of Technology, and Harvard University have uncovered a crucial component for restoring functional activity after spinal cord injury.

21 Sep 2023

Compound found in hops can combat metabolic syndrome by reducing Oscillibacter population

Researchers have shown in a mouse model and lab cultures that a compound derived from hops reduces the abundance of a gut bacterium associated with metabolic syndrome.

21 Sep 2023

New treatment approach effectively treats the most aggressive forms of prostate cancer

Researchers at the University of Chicago Medicine Comprehensive Cancer Center established "proof-of-concept" for a new treatment approach that was able to effectively treat the most aggressive forms of prostate cancer. The treatment showed complete tumor control and long-lasting survival without side effects in a mouse model of advanced prostate cancer.

19 Sep 2023

Nanoparticle gene delivery system shows promise for treating ARDS

Discovery from the lab of Youyang Zhao, PhD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago offers promising treatment approaches for acute respiratory distress syndrome (ARDS) in the elderly that can be caused by severe COVID-19, pneumonia, flu or sepsis. Currently there are no pharmacological or cell-based treatments for ARDS.

19 Sep 2023

Researchers identify key mechanisms to address future treatments for hereditary blindness

There are still many enigmas about the mechanism of action of the CERKL gene, which causes retinitis pigmentosa and other hereditary vision diseases.

18 Sep 2023

Turning fish waste into cancer fighters: How abalone viscera peptides could be the next big thing in medicine

Researchers explore the potential of bioactive peptides from abalone fish viscera for their antimicrobial and anticancer properties. The study finds promising activity against various bacterial and fungal strains, as well as cytotoxic effects on prostate cancer cells.

17 Sep 2023

Chemotherapy drug may promote cancer growth by injuring surrounding cells

A standard chemotherapy drug injures surrounding non-cancer cells, which can then awakens dormant cancer cells and promotes cancer growth, according to a new study publishing September 12th in the open access journal PLOS Biology by Ramya Ganesan of Emory University, US, and colleagues.

12 Sep 2023

Human post-implantation embryo models show promise in unraveling early development

Researchers evaluate post-implantation development in humans using embryo-like models based on genetically unmodified human naïve embryonic stem cells.

12 Sep 2023

Ketogenic dietary intervention may inhibit onset and progression of neuroendocrine tumors

A recent Cell Death and Disease study evaluated the effect of ketogenic dietary intervention on neuroendocrine tumors.

12 Sep 2023

PI3K pathway rewiring drives prostate cancer growth

Experts in cell signaling at the Babraham Institute have identified how prostate cancer cells achieve cell growth free from the usual growth cues and regulators.

11 Sep 2023

Study evaluating intranasal anti-CD3 for treatment of Alzheimer’s disease published in the PNAS journal

Tiziana Life Sciences Ltd. (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies via novel routes of drug delivery, today announced acceptance of a publication, “Nasal Administration of anti-CD3 monoclonal antibody (mAb) ameliorates disease in a mouse model of Alzheimer’s disease”, in the preeminent journal, Proceedings of the National Academy of Sciences (PNAS), that supports foralumab’s mechanism as a potential treatment for Alzheimer’s disease (AD), a difficult-to-treat neuroinflammatory disease.

9 Sep 2023

A subset of CD8+ T cells can play a protective role against Alzheimer’s disease pathogenesis

Scientists at St. Jude Children’s Research Hospital found that a subset of CD8+ T cells in the brain lessens the activation of microglia and limits disease pathology in a model of Alzheimer’s disease.

8 Sep 2023

Chronic inflammation's influence on TP53 mutations in leukemia evolution explored in new study

Researchers performed a multi-omics evaluation of HSPCs obtained from individuals with myeloproliferative neoplasms transforming to TP53-related secondary forms of acute myeloid leukemia.

7 Sep 2023

Mouse Model News and Research

Effectiveness of Lactobacillus in treating inflammatory bowel disease

Trametinib: Potential therapeutic game-changer for Alzheimer's disease

New discovery could delay relapse in triple-negative breast cancer

Researchers discover how Zika virus persists in the placenta

Engineered mice reveal how Omicron subvariant BA.5 is more virulent

New model paves way to understanding and preventing SUDEP in familial epilepsy

Peptide vaccine targets H3K27M mutation in midline gliomas, shows promise in early trials

Scientists uncover a crucial component for restoring functional activity after spinal cord injury

Compound found in hops can combat metabolic syndrome by reducing Oscillibacter population

New treatment approach effectively treats the most aggressive forms of prostate cancer

Nanoparticle gene delivery system shows promise for treating ARDS

Researchers identify key mechanisms to address future treatments for hereditary blindness

Turning fish waste into cancer fighters: How abalone viscera peptides could be the next big thing in medicine

Chemotherapy drug may promote cancer growth by injuring surrounding cells

Human post-implantation embryo models show promise in unraveling early development

Ketogenic dietary intervention may inhibit onset and progression of neuroendocrine tumors

PI3K pathway rewiring drives prostate cancer growth

Study evaluating intranasal anti-CD3 for treatment of Alzheimer’s disease published in the PNAS journal

A subset of CD8+ T cells can play a protective role against Alzheimer’s disease pathogenesis

Chronic inflammation's influence on TP53 mutations in leukemia evolution explored in new study

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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