Mouse Model News and Research

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Resistance training could be a simple and affordable therapy for Alzheimer's patients

Regular physical exercise, such as resistance training, can prevent Alzheimer's disease, or at least delay the appearance of symptoms, and serves as a simple and affordable therapy for Alzheimer's patients.

3 Jul 2023

Ancient retrovirus may be responsible for aggressive brain cancers

The median length of survival after diagnosis of glioblastoma is 14 months, but some of these brain tumors are more aggressive and resistant to treatment than others, and a new study from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine suggests reactivation of an ancient retrovirus may be at least partly to blame.

3 Jul 2023

Cell therapy using genome-edited iPS cells could be a new treatment for Fabry disease

Induced pluripotent stem (iPS) cells have a great impact on biology and medicine, and they are expected to improve regenerative medicine.

3 Jul 2023

Spanish researchers develop new immunotherapy combination for liver cancer

Spanish researchers at Cima University of Navarra have developed a new immunotherapy combination that improves efficacy in animal models of hepatocellular carcinoma. This is a proof of concept that lays the foundations for the application of this treatment in patients with the most common liver cancer.

1 Jul 2023

Novel drug combination shows promise in treating pancreatic cancer

Mutations in the KRAS gene are the major driver of pancreatic cancer. The resulting protein controls multiple signaling pathways involved in cell growth and survival. In cancer, the gene is mutated to be permanently "on," driving cells to excessively multiply and form tumors.

28 Jun 2023

GREB1 gene key to liver cancer development, study finds

The development of hepatocellular carcinoma, liver cancer, is known to involve abnormal activation of a signaling pathway called Wnt; however, the underlying mechanisms have not been fully understood, until now.

27 Jun 2023

Study reveals neural circuits underlying adolescent stress-induced postpartum social behavior

Stress during adolescence can cause postpartum behavioral changes in women and other mammals, including depression and changes in social behavior after the birth of a child.

23 Jun 2023

Research explains mechanisms behind anti-viral protection in hemochorial placentas

Give credit to your dad's gene for keeping you safe during those long months in your mother's womb.

20 Jun 2023

Oral probiotic bacterial strain found to improve dry eye disease in animal model

In a study by a research group at Baylor College of Medicine, oral administration of a commercially available probiotic bacterial strain was found to improve dry eye disease in an animal model.

18 Jun 2023

Does taurine deficiency speed up aging?

The association of the amino acid taurine with aging.

16 Jun 2023

Determining the effect of estriol treatment on cerebral cortex in the preclinical model of MS

Treating a mouse model of multiple sclerosis with the pregnancy hormone estriol reversed the breakdown of myelin in the brain's cortex, a key region affected in multiple sclerosis, according to a new UCLA Health study.

16 Jun 2023

Moderate exercise can influence the inflammatory responses of macrophages, research shows

Researchers have long known that moderate exercise has a beneficial impact on the body's response to inflammation, but what's been less understood is why.

15 Jun 2023

Detailed 3D images of the synapse offer precise geometry of interactions between individual cells

Scientists have created one of the most detailed 3D images of the synapse, the important juncture where neurons communicate with each other through an exchange of chemical signals. These nanometer scale models will help scientists better understand and study neurodegenerative diseases such as Huntington's disease and schizophrenia.

15 Jun 2023

Exploring how Bourbon virus-carrying ticks travel through wildlife and to people

On a cold spring morning, Washington University in St. Louis virologist Jacco Boon, PhD, and wildlife ecologist Solny Adalsteinsson, PhD, flap and drag a large white flag through a woodsy area on the western edge of St. Louis County. Boon, an associate professor of medicine in infectious diseases at Washington University School of Medicine in St. Louis, and Adalsteinsson, a senior scientist at the university's Tyson Research Center, are looking for lone star ticks that carry the potentially deadly Bourbon virus.

14 Jun 2023

Mouse Model News and Research

Resistance training could be a simple and affordable therapy for Alzheimer's patients

Ancient retrovirus may be responsible for aggressive brain cancers

Cell therapy using genome-edited iPS cells could be a new treatment for Fabry disease

Spanish researchers develop new immunotherapy combination for liver cancer

Novel drug combination shows promise in treating pancreatic cancer

GREB1 gene key to liver cancer development, study finds

Study reveals neural circuits underlying adolescent stress-induced postpartum social behavior

Research explains mechanisms behind anti-viral protection in hemochorial placentas

Oral probiotic bacterial strain found to improve dry eye disease in animal model

Does taurine deficiency speed up aging?

Determining the effect of estriol treatment on cerebral cortex in the preclinical model of MS

Moderate exercise can influence the inflammatory responses of macrophages, research shows

Detailed 3D images of the synapse offer precise geometry of interactions between individual cells

Exploring how Bourbon virus-carrying ticks travel through wildlife and to people

Transgenic mouse model reveals surprising new connections between peripheral nerves and the heart

Mutations that lead to intracranial aneurysms discovered

Using ultrasound for an effective sonodynamic treatment of orthotopic pancreatic cancer

Understanding the developmental link: vitamin D's role in metabolic disease risk

Simple juice concentrate from the Japanese plum may reduce cardiovascular disease risk

Antiretroviral treatment efficiently suppresses penile HIV replication

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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