Mouse Model News and Research

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What is the efficacy, safety, and tolerability of novel danuglipron in adults with type two diabetes?

Researchers assessed the safety and efficacy of danuglipron in type 2 diabetes (T2D) patients.

24 May 2023

Oxygen restriction associated with longer lifespan in lab mice

For the first time, researchers have shown that reduced oxygen intake, or "oxygen restriction", is associated with longer lifespan in lab mice, highlighting its anti-aging potential.

24 May 2023

Looking at cancer drugs to help put the brakes on classic indicators of aging

Antiretroviral cocktails can make human immunodeficiency virus, or HIV, undetectable and untransmittable, but both the virus and its treatment can also accelerate aging of bone and muscle.

24 May 2023

Metabolic sensors may play a role in the development of Alzheimer's disease, study suggests

It's well-known that people with Type 2 diabetes are at an increased risk of developing Alzheimer's disease, but the reason why isn't fully understood and is an area of current research.

22 May 2023

Surviving without glucose: uridine-derived ribose as an alternative energy source

Researchers attempted to identify new genes and molecular pathways that might supply energy when the availability of glucose or other nutrients is limited.

22 May 2023

Study could help understand why limiting sugary foods can ease symptoms for IBD patients

Excess sugar hampers cells that renew the colon's lining in a mouse model of inflammatory bowel disease (IBD), according to a new study by University of Pittsburgh scientists.

22 May 2023

Hydrogel combines nanozymes and probiotics for effective Candida vaginitis treatment

Research introduces FeLab, a responsive hydrogel that combines nanozymes and probiotics for the treatment of Candida vaginitis. FeLab demonstrates effective anti-Candida activity, promotes vaginal mucosa repair, and restores healthy vaginal microbiota, offering a promising therapeutic approach for this condition.

21 May 2023

Change in liver clock could affect synchronization of the circadian cycle

Organisms rely on a biological clock known as the 'circadian' clock to regulate their activity according to the time of day.

17 May 2023

Oral cancer game-changer: Researchers develop 'normalized nerve density' metric for tumor assessment

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17 May 2023

Mast cells play a crucial role in the development of chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a type of blood cancer that arises from malignant changes in blood-forming cells of the bone marrow.

16 May 2023

Phase 1 clinical trial of CAR-NKT cell therapy shows promising results in neuroblastoma patients

Researchers at Baylor College of Medicine/Texas Children's Cancer Center and collaborating institutions report interim results from a first-in-human phase 1 clinical trial evaluating the safety, antitumor activity and immunological characteristics of a genetically engineered natural killer T (NKT) cell immunotherapy for neuroblastoma, a childhood tumor that most commonly arises in the adrenal gland.

15 May 2023

Newly identified genetic variant provides protection from Alzheimer's disease

A single patient can spark new research questions and provide answers about a disease. And when a new case is identified, investigators can make connections between them that can lead to even more powerful and persuasive ideas about cause and treatment.

15 May 2023

Study offers new insights into how toxic proteins spread in the brains of people with Alzheimer's disease

Fresh insights into the spread of damaging proteins that build up in the brains of people with Alzheimer's disease could hold the key to stopping the condition progressing, a study says.

15 May 2023

Humanized mouse model for rare genetic disease developed for the first time

Mice with a defected human gene responsible for a rare genetic disease, called congenital adrenal hyperplasia, have been developed for the first time.

15 May 2023

High-fat diets can promote atherosclerosis via gut bacteria interactions with the immune system

In a recent study, researchers determined that derivatives of natural emulsifiers such as phospholipids found in high-fat, high-cholesterol diets can promote atherosclerosis via gut bacteria interactions with the immune system.

11 May 2023

Exposure to traffic-related air pollution leads to memory loss and cognitive decline

Researchers from the University of California, Irvine have found that exposure to traffic-related air pollution in Irvine led to memory loss and cognitive decline and triggered neurological pathways associated with the onset of Alzheimer's disease.

11 May 2023

Research sheds light on the early cellular events that give rise to pancreatic cancer

Discussions of cancer often stress the genetic mutations that drive disease by altering the normal function of cellular proteins.

11 May 2023

Analyzing impact of phospholipase D on the host immune response to A. fumigatus infection

Announcing a new article publication for Zoonoses journal. Aspergillus fumigatus infection in the lungs is accompanied by the recruitment of innate immune cells, phagocytosis, and the release of inflammatory factors.

11 May 2023

Ketogenic diet's surprising impact on opioid sensitivity and withdrawal

Research investigates the effects of a ketogenic diet (KD) on responses to oxycodone, a commonly prescribed opioid for pain management. The study found sex-biased effects of KD on oxycodone responses in mice, suggesting potential implications for clinical pain management and treatment of opioid use disorder.

10 May 2023

New SNAP approach to customizing T cell-based immunotherapies

University of Pittsburgh researchers have developed a universal receptor system that allows T cells to recognize any cell surface target, enabling highly customizable CAR T cell and other immunotherapies for treating cancer and other diseases.

9 May 2023

Mouse Model News and Research

What is the efficacy, safety, and tolerability of novel danuglipron in adults with type two diabetes?

Oxygen restriction associated with longer lifespan in lab mice

Looking at cancer drugs to help put the brakes on classic indicators of aging

Metabolic sensors may play a role in the development of Alzheimer's disease, study suggests

Surviving without glucose: uridine-derived ribose as an alternative energy source

Study could help understand why limiting sugary foods can ease symptoms for IBD patients

Hydrogel combines nanozymes and probiotics for effective Candida vaginitis treatment

Change in liver clock could affect synchronization of the circadian cycle

Oral cancer game-changer: Researchers develop 'normalized nerve density' metric for tumor assessment

Mast cells play a crucial role in the development of chronic myeloid leukemia

Phase 1 clinical trial of CAR-NKT cell therapy shows promising results in neuroblastoma patients

Newly identified genetic variant provides protection from Alzheimer's disease

Study offers new insights into how toxic proteins spread in the brains of people with Alzheimer's disease

Humanized mouse model for rare genetic disease developed for the first time

High-fat diets can promote atherosclerosis via gut bacteria interactions with the immune system

Exposure to traffic-related air pollution leads to memory loss and cognitive decline

Research sheds light on the early cellular events that give rise to pancreatic cancer

Analyzing impact of phospholipase D on the host immune response to A. fumigatus infection

Ketogenic diet's surprising impact on opioid sensitivity and withdrawal

New SNAP approach to customizing T cell-based immunotherapies

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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