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Study offers new insights into how toxic proteins spread in the brains of people with Alzheimer's disease

Fresh insights into the spread of damaging proteins that build up in the brains of people with Alzheimer's disease could hold the key to stopping the condition progressing, a study says.

15 May 2023

Humanized mouse model for rare genetic disease developed for the first time

Mice with a defected human gene responsible for a rare genetic disease, called congenital adrenal hyperplasia, have been developed for the first time.

15 May 2023

High-fat diets can promote atherosclerosis via gut bacteria interactions with the immune system

In a recent study, researchers determined that derivatives of natural emulsifiers such as phospholipids found in high-fat, high-cholesterol diets can promote atherosclerosis via gut bacteria interactions with the immune system.

11 May 2023

Exposure to traffic-related air pollution leads to memory loss and cognitive decline

Researchers from the University of California, Irvine have found that exposure to traffic-related air pollution in Irvine led to memory loss and cognitive decline and triggered neurological pathways associated with the onset of Alzheimer's disease.

11 May 2023

Research sheds light on the early cellular events that give rise to pancreatic cancer

Discussions of cancer often stress the genetic mutations that drive disease by altering the normal function of cellular proteins.

11 May 2023

Analyzing impact of phospholipase D on the host immune response to A. fumigatus infection

Announcing a new article publication for Zoonoses journal. Aspergillus fumigatus infection in the lungs is accompanied by the recruitment of innate immune cells, phagocytosis, and the release of inflammatory factors.

11 May 2023

Ketogenic diet's surprising impact on opioid sensitivity and withdrawal

Research investigates the effects of a ketogenic diet (KD) on responses to oxycodone, a commonly prescribed opioid for pain management. The study found sex-biased effects of KD on oxycodone responses in mice, suggesting potential implications for clinical pain management and treatment of opioid use disorder.

10 May 2023

New SNAP approach to customizing T cell-based immunotherapies

University of Pittsburgh researchers have developed a universal receptor system that allows T cells to recognize any cell surface target, enabling highly customizable CAR T cell and other immunotherapies for treating cancer and other diseases.

9 May 2023

High-fat diets' eye-opening impact: Study reveals link to retinal damage and bisretinoid accumulation

In this study, the effects of a high-fat diet on the formation of bisretinoids in photoreceptor cells were explored. The results showed that mice on a high-fat diet had increased levels of bisretinoids and retinol-binding protein 4, which are associated with metabolic dysregulation.

8 May 2023

Cancer-fighting immune cells can fuel their ability to attack tumors

When you need a bit of motivation, it often has to come from within. New research suggests cancer-fighting immune cells have found a way to do just that.

8 May 2023

Researchers evaluate the dual-therapeutic effect of gene therapy in mouse model of osteosarcoma

Investigators at Brigham and Women’s Hospital and collaborating institutions evaluated the dual-therapeutic effect of gene therapy in a clinically relevant model for common form of bone cancer.

8 May 2023

Neuropathic pain study uncovers pathophysiological mechanism and promising therapeutic target

Neuropathic pain -; abnormal hypersensitivity to stimuli -; is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV.

5 May 2023

Mouse Model News and Research

Study offers new insights into how toxic proteins spread in the brains of people with Alzheimer's disease

Humanized mouse model for rare genetic disease developed for the first time

High-fat diets can promote atherosclerosis via gut bacteria interactions with the immune system

Exposure to traffic-related air pollution leads to memory loss and cognitive decline

Research sheds light on the early cellular events that give rise to pancreatic cancer

Analyzing impact of phospholipase D on the host immune response to A. fumigatus infection

Ketogenic diet's surprising impact on opioid sensitivity and withdrawal

New SNAP approach to customizing T cell-based immunotherapies

High-fat diets' eye-opening impact: Study reveals link to retinal damage and bisretinoid accumulation

Cancer-fighting immune cells can fuel their ability to attack tumors

Researchers evaluate the dual-therapeutic effect of gene therapy in mouse model of osteosarcoma

Neuropathic pain study uncovers pathophysiological mechanism and promising therapeutic target

Wistar scientists uncover a key mechanism as to how p53 suppresses tumors

Study finds a pharmacological-based approach to revert immune escape of breast cancer cells

Finnish mitochondrial disease of newborns shows cancer-like changes in proliferating cells

New technology can deliver gene therapy directly to the lung

Drugs targeting FXR1 may treat vascular proliferative diseases

Novel chronic murine wound mouse model to study cellular senescence

Inhibiting mitochondrial regulator ATAD3A could prevent head and neck cancer development

Scientists identify broad-spectrum antiviral agents that can target multiple RNA virus families

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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