Mouse Model News and Research

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Peptide loaded gold nanospheres find, penetrate, then fuel burning of melanoma

Hollow gold nanospheres equipped with a targeting peptide find melanoma cells, penetrate them deeply, and then cook the tumor when bathed with near-infrared light, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reported in the Feb. 1 issue of Clinical Cancer Research.

2 Feb 2009

Genetic change prevents cell death in mouse model of Parkinson's disease

By shifting a normal protective mechanism into overdrive, a University of Wisconsin-Madison scientist has completely shielded mice from a toxic chemical that would otherwise cause Parkinson's disease.

2 Feb 2009

New potential targets for colitis-associated cancer

Recent research from the laboratory of Michael Karin, PhD, at the University of California, San Diego School of Medicine - the first researcher to demonstrate a molecular link between inflammation and cancer - has identified two potential targets for the prevention and treatment of colitis-associated cancer (CAC), the most serious complication of inflammatory bowel disease.

2 Feb 2009

New insights into growth factor's role in brain development

New research sheds light on a neural growth factor called proBDNF, finding that it is present and potentially active during the perinatal period when the brain's circuitry and memory-encoding regions are being refined.

2 Feb 2009

Opposite approach to asthma treatment may be in order

Just when the Food and Drug Administration is reconsidering the use of stimulants to treat asthma, a new research study offers further evidence to support a University of Houston professor's theory that an opposite approach to asthma treatment may be in order.

27 Jan 2009

Scientist decodes the language of memory cells

When an infection attacks, the body's immune system sounds the alert, kills the invading germs and remembers the pathogen to protect against contracting the same type of infection again.

23 Jan 2009

Blocked Interleukin 21 protein prevents Lupus in mouse model

Mice from a strain that ordinarily develops systemic lupus erythematosus (SLE), but bred with a deficiency in receptor for the protein Interleukin 21, stayed healthy and exhibited none of the symptoms of the disease, researchers at The Jackson Laboratory and National Institutes of Health report.

21 Jan 2009

Discovery of new regulatory circuit controlling immune cell production in mice

Using a mouse model, researchers have shown that elevated levels of a small protein known as interleukin 7 (IL-7) plays a central role in regulating the production of a type of white blood cell that is required for effective immune responses.

12 Jan 2009

New mouse model for peanut allergy

Chicago researchers report the development of a new mouse model for food allergy that mimics symptoms generated during a human allergic reaction to peanuts.

12 Jan 2009

First artemisinin based malaria drug may meet resistance, expert says

This year, the U.S. Food and Drug Administration is expected to approve the first malaria drug to contain artemisinin, a wormwood derivative from China that has proven effective for malaria in Africa and Asia.

8 Jan 2009

New nasal spray vaccine shown to be effective against botulism

A preclinical study found a new nasal spray vaccine to provide complete protection against a major botulism toxin, according to a study published today in the Nature journal Gene Therapy .

8 Jan 2009

New hope for leptin as a solution to obesity

The discovery more than a decade ago of leptin, an appetite-suppressing hormone secreted by fat tissue, generated headlines and great hopes for an effective treatment for obesity.

6 Jan 2009

Collagen VI protects brain cells against amyloid-beta proteins

Scientists from the Gladstone Institute of Neurological Disease (GIND), UCSF, and Stanford have discovered that a certain type of collagen, collagen VI, protects brain cells against amyloid-beta proteins, which are widely thought to cause Alzheimer's disease (AD).

5 Jan 2009

Discovery of new tumor suppressor for lung cancer

Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer.

5 Jan 2009

A novel glioblastoma mouse model developed

Researchers at the Salk Institute for Biological Studies have developed a versatile mouse model of glioblastoma-the most common and deadly brain cancer in humans-that closely resembles the development and progression of human brain tumors that arise naturally.

5 Jan 2009

Laminin-111 shows potential for congenital muscular dystrophy

Current research suggests laminin, a protein that helps cells stick together, may lead to enhanced muscle repair in muscular dystrophy.

1 Jan 2009

Lung cancer cells activate inflammation to induce metastasis

A research team from the University of California, San Diego School of Medicine has identified a protein produced by cancerous lung epithelial cells that enhances metastasis by stimulating the activity of inflammatory cells.

1 Jan 2009

Diet high in inorganic phosphates increases risk of lung cancer

New research in an animal model suggests that a diet high in inorganic phosphates, which are found in a variety of processed foods including meats, cheeses, beverages, and bakery products, might speed growth of lung cancer tumors and may even contribute to the development of those tumors in individuals predisposed to the disease.

30 Dec 2008

Stem cells and leukemia battle for marrow microenvironment

Learning how leukemia takes over privileged "niches" within the bone marrow is helping researchers develop treatment strategies that could protect healthy blood-forming stem cells and improve the outcomes of bone marrow transplantation for leukemia and other types of cancer.

18 Dec 2008

New method offers direct access to the brain through the nose to treat stroke

UT Health Science Center San Antonio researchers, working in a mouse model of stroke, are delivering neuroprotective drugs to the brain by spraying them onto the lining of a nerve in the nose.

18 Dec 2008