Muscle Atrophy News and Research

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Motor neurons derived from human embryonic stem cells provide insight into ALS

Two new research studies use motor neurons derived from human embryonic stem (hES) cells to demonstrate that multiple toxic pathways contribute to the devastating degeneration associated with Amyotrophic Lateral Sclerosis (ALS) and that protective therapeutics will need to oppose the disease on multiple fronts.

3 Dec 2008

Researchers develop human embryonic stem cell-based system for modeling ALS

Long thought of as mere bystanders, astrocytes are crucial for the survival and well-being of motor neurons, which control voluntary muscle movements.

3 Dec 2008

Long-term use of mechanical ventilation contributes to the deterioration of human diaphragm muscle

A new study by University of Pennsylvania School of Medicine shows, for the first time in humans, that ventilators combined with diaphragm disuse contributes to muscle atrophy in the diaphragm in as little as eighteen hours.

28 Mar 2008

Toxic organophosphates appear to contribute to motor neuron disease

Motor neuron disease is a rare, devastating illness in which nerve cells that carry brain signals to muscles gradually deteriorate.

24 Mar 2008

SnowWorld, an interactive, virtual-reality video game helps burn patients with pain relief

To a patient recovering from severe burns, no place would be more soothing than a polar landscape of gently falling snowflakes, snowmen, penguins, igloos and icy rivers.

19 Mar 2008

Discovery of molecular signal that helps muscle regenerate and protects it from atrophy

It does not take much to injure a muscle. Sometimes one sudden, inconsiderate movement does the job.

20 Dec 2007

Discovery of gene responsible for statin-induced muscle pain

Statins, the popular class of drugs used to lower cholesterol, are among the most commonly prescribed medications in developed countries.

27 Nov 2007

Novel mutation associated with muscle identified

The study demonstrates that muscle weakness experienced by persons with a regulatory protein tropomyosin mutation is directly related to a mechanism by which the mutant tropomyosin modulates contractile speed and force-generation capacity.

17 Jun 2007

Creatine may help Parkinson's patients by giving an energy boost to dying cells

Whether a supplement used by athletes to boost energy levels and build muscle can slow progression of Parkinson's disease is the focus of a North American study.

22 Mar 2007

Unpleasant memories from intensive care

"Being cared for in an intensive care unit (ICU) can never be an especially positive experience. But at any rate it should not mean that the care improves the patient's physical condition only to leave him or her with severe mental problems!"

20 Sep 2006

Research illustrates BAG3 protein's importance in maintaining mature skeletal muscle

Muscle cells that should grow stronger with use instead self-destruct when a protein called BAG3 isn't around, researchers have shown.

30 Aug 2006

New roles for growth factors

During embryonic development, nerve cells hesitantly extend tentacle-like protrusions called axons that sniff their way through a labyrinth of attractive and repulsive chemical cues that guide them to their target.

18 Jun 2006

Early intervention is a critical consideration in efforts to preserve the musculoskeletal system after spinal cord injury

Richard Shields, Ph.D., University of Iowa professor in the Graduate Program in Physical Therapy and Rehabilitation Science, can foresee a time when it might be possible to cure spinal cord injury (SCI).

7 Apr 2006

First human trials start in Canada for muscle-derived stem cells as a treatment for urinary incontinence

Human muscle-derived cells, pluripotent stem cells found in muscle, have been used to cure stress urinary incontinence in animal models, a finding which signals that these cells are prime candidates to treat the condition in adults.

31 Aug 2005

Gene dynamin 2 underlies one form of Charcot-Marie-Tooth disease

A gene that plays many fundamental roles in cells throughout the body has, for the first time, been implicated in human disease, according to researchers at the Duke Center for Human Genetics.

31 Jan 2005

Medical device innovations - fabricating the future

Two large pieces of metal lie on the floor of what looks like a mini-factory in the Cleveland Clinic’s Lerner Research Institute. The whirring machinery here stamps out prototypes of medical devices imagined by clinicians and researchers to help with diagnostic testing or surgical procedures.

9 Jan 2005

Cancer drug paclitaxel may reduce the adverse effects of Alzheimer's disease

In a preclinical efficacy trial, the cancer drug paclitaxel (Paxceed)–which exerts its effects by binding to and stabilizing microtubules inside cells–reduced the adverse effects of Alzheimer's disease (AD)-like pathology in a mouse model.

20 Dec 2004