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Data suggesting that omacetaxine can eradicate leukemic stem cells may offer a breakthrough for CML

Data showing the ability of omacetaxine to kill leukemic stem cells in mouse models with drug-resistant chronic myelogenous leukemia (CML) are the subject of an advance online publication in the journal Leukemia, ChemGenex Pharmaceuticals Limited (ASX:CXS and NASDAQ:CXSP) announced today.

29 Mar 2009

Mutations in a gene may stunt lung development in children

Mutations in a gene may cause poor lung development in children, making them more vulnerable to diseases such as chronic obstructive pulmonary disease (COPD) later in life, say researchers at the University of Pittsburgh Graduate School of Public Health and the German Research Center for Environmental Health.

29 Mar 2009

Recently identified genetic heart disorder often deadly for young patients

A study that included young patients with a recently recognized rare type of cardiomyopathy (a disorder of the heart muscle) linked to a genetic mutation finds that progression of this disease may be rapid and often results in early death, according to a study in the March 25 issue of JAMA.

24 Mar 2009

Rewrite of the recipe for life - new type of DNA

In a dramatic rewrite of the recipe for life, scientists from Florida today described the design of a new type of DNA with 12 chemical letters instead of the usual four.

23 Mar 2009

Common gene variations found to influence risk factor for sudden cardiac death

A new study has identified several common genetic variants related to a risk factor for sudden cardiac death.

23 Mar 2009

Tiny genetic change keeps nicotine from binding to muscle cells

A tiny genetic mutation is the key to understanding why nicotine--which binds to brain receptors with such addictive potency--is virtually powerless in muscle cells that are studded with the same type of receptor.

23 Mar 2009

Discovery of genetic link to blood cancers

The study, published in the journal Nature Genetics, has shown that susceptibility to a series of blood cancers, known as myeloproliferative disorders (MPDs), is linked to a particular area of the patient's DNA, which is prone to developing mutations.

22 Mar 2009

Researchers investigate new way to block reproduction of the hepatitis C virus

Massachusetts General Hospital (MGH) researchers are investigating a new way to block reproduction of the hepatitis C virus (HCV) - targeting not the virus itself but the human genes the virus exploits in its life cycle.

20 Mar 2009

Schizophrenia gene found to control the birth of new neurons

A gene that is arguably the most studied "schizophrenia gene" plays an unanticipated role in the brain: It controls the birth of new neurons in addition to their integration into existing brain circuitry, according to a report in the March 20th issue of the journal Cell, a Cell Press publication.

20 Mar 2009

Research yields potential target for cancer, wound healing and fibrosis

Research conducted by Allison Berrier, PhD, Assistant Professor of Oral and Craniofacial Biology at the LSU Health Sciences Center New Orleans School of Dentistry, and colleagues, provides insights that may help scientists design novel approaches to control wound healing and fight diseases such as cancer and fibrosis.

20 Mar 2009

Discovery of new protein important in breast cancer gene's role in DNA repair

For years, researchers have known that under normal conditions, the breast cancer protein BRCA1 orchestrates the repair of damaged DNA, but the details of just how BRCA1 moves to the damaged site and recruits the right nuclear repairmen for DNA restoration remains a mystery.

20 Mar 2009

Paradigm shift in the regulation of immune response

Over the past decade various pieces of the puzzle how signal transmission controls immunity have been coming together.

20 Mar 2009

Understanding mental illness through gene-environment interactions

Biological Psychiatry, published by Elsevier, is very pleased to present a special section of its February 1st issue devoted to fundamental new insights into epigenetics, a field of research devoted to understanding how the environment can produce long-lasting or even heritable changes in gene function without altering the DNA sequence.

17 Mar 2009

Engineering flu vaccines

A new computerized method of testing could help world health officials better identify flu vaccines that are effective against multiple strains of the disease.

17 Mar 2009

Search for blood pressure secrets reveals a surprising new syndrome

Yale researchers investigating the genetic causes of blood pressure variation have identified a previously undescribed syndrome associated with seizures, a lack of coordination, developmental delay and hearing loss.

16 Mar 2009

Scientists 'watch' as individual alpha-synuclein proteins change shape

In an Early Edition publication of The Proceedings of the National Academy of Sciences (PNAS) this week, the researchers demonstrate the "alpha-synuclein dance" - the switching back and forth of the protein between a bent helix and an extended helix as the surface that it is binding to changes.

16 Mar 2009

Genetic links to high levels of HDL cholesterol

HDL cholesterol (HDL-C), or "good" cholesterol, carries excess cholesterol - that might otherwise block arteries - from blood vessels back to the liver for processing and elimination.

16 Mar 2009

First treatment for muscular dystrophy a step closer

Genetic researchers at Children's National Medical Center and the National Center of Neurology and Psychiatry in Tokyo published the results of the first successful application of "multiple exon-skipping" to curb the devastating effects of Duchenne muscular dystrophy in an animal larger than a mouse.

16 Mar 2009

Novel genetic technology for canine form of muscular dystrophy

Using a novel genetic technology that covers up genetic errors, researchers funded in part by the National Institutes of Health have developed a successful treatment for dogs with the canine version of Duchenne muscular dystrophy, a paralyzing, and ultimately fatal, muscle disease.

16 Mar 2009