Mycology News and Research

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New compound could take on lethal fungal, bacterial infections in immunocompromised people

Immunodeficiency is the condition where the capability of the immune system to fight against diseases has been compromised.

25 Sep 2019

Scientists investigate how fungus interacts with bacteria to trigger Crohn's disease

Scientists have known that bacteria in the gut, along with environmental and genetic factors, contribute to the debilitating intestinal ailment of Crohn's disease.

26 Jul 2019

Patent-pending probiotic could help patients with gastrointestinal diseases avoid harmful biofilms

Probiotics typically aim to rebalance bacteria populations in the gut, but new research suggests they may also help break apart stubborn biofilms. Biofilms are living microbial communities--they provide a haven for microbes and are often resistant to antibiotics.

4 Apr 2019

Researchers find how Aspergillus fumigatus knocks out immune defenses

Research team from the University of Jena clarifies the mechanism of gliotoxin, a mycotoxin from the fungus Aspergillus fumigatus. The researchers present their findings in the current issue of the specialist journal Cell Chemical Biology

11 Feb 2019

Cloned antibodies show potential to treat, diagnose life-threatening fungal infections

Despite public health efforts, many people who get fungal infections in their blood streams die, even if they can be identified and treated with antifungal drugs. These therapies are often ineffective on their own and increasingly the infections are becoming resistant to treatment with some of the front line antifungal drugs.

11 Dec 2018

Cidara initiates Phase 3 clinical trial to evaluate efficacy, safety of rezafungin to treat invasive candidiasis

Cidara Therapeutics, Inc., a biotechnology company developing novel anti-infectives including immunotherapies, today announced that the first trial site has been activated for ReSTORE, a Phase 3 clinical trial evaluating the efficacy and safety of the company's lead antifungal, rezafungin, to treat candidemia and invasive candidiasis.

27 Sep 2018

Mushrooms from the Far East area could be used to design novel anti-cancer drugs

Mushrooms from the Far East area contain the natural chemical compounds, which could be used for the design of the novel drugs with highly specific anti-tumor activities and low-toxicity.

2 Aug 2018

Bruker's MALDI Biotyper OMA receives AOAC Method of the Year award in food microbiology

At the 2018 Annual Meeting of the International Association of Food Protection (www.foodprotection.org/), Bruker announces a standardized workflow for any microbial isolate confirmation and identification in food microbiology.

From Bruker Life Sciences Mass Spectrometry 10 Jul 2018

Candida Auris testing kit for use in hospital hygiene applications announced by Bruker

At the International Society for Human and Animal Mycology meeting, Bruker announces Fungiplex™ Candida Auris, a new research-use-only, real-time PCR assay and kit for the detection of Candida auris in hospital hygiene applications.

From Bruker Life Sciences Mass Spectrometry 4 Jul 2018

ACTA trial in AIDS patients with cryptococcal meningitis validates new therapeutic regimens

The results of the ACTA trial were presented at the 9th IAS Conference on HIV Science held in Paris from 23 to 26 July 2017. Professor Thomas Harrison and his colleagues at St George's University of London, the Institut Pasteur in Paris, Paris Descartes University (Hôpital Necker-Enfants Malades), the ANRS site in Cameroon, and the MRC sites in Malawi, Tanzania, and Zambia show in this trial that new therapeutic regimens are of benefit in HIV-infected patients with cryptococcal meningitis.

15 Mar 2018

New blood test offers quick, accurate diagnosis of deadly yeast infection

A new blood test seems to perform as well as, if not better than, traditional blood cultures at detecting a type of fungal yeast infection that commonly strikes hospital patients, according to an analysis led by UPMC.

8 Feb 2018

Novel antifungal shows promise to stave off drug-resistant superbugs

Microscopic yeast have been wreaking havoc in hospitals around the world- creeping into catheters, ventilator tubes, and IV lines- and causing deadly invasive infection.

11 Jan 2018

Survival strategy of mRNAs during sugar deficiency in the cell

If a cell runs low on sugar, it stores certain messenger RNAs in order to prolong its life. As a research group at the Biozentrum of the University of Basel has now discovered, the protein Puf5p determines whether individual messenger RNAs will be stored or degraded when sugar levels are low.

9 Jan 2018

New research hub set up to help stop future outbreaks of killer diseases

A ground-breaking new research hub has been set up to help halt future outbreaks of killer diseases like Ebola and Zika.

3 Jan 2018

Multifunctional protein also plays role in development of blood cells

Like an actor who excels at both comedy and drama, proteins also can play multiple roles. Uncovering these varied talents can teach researchers more about the inner workings of cells.

21 Dec 2017

New genetic analysis of candidiasis reveals surprising fungal sex secrets

Working together with researchers in the Université Paris-Sud in France and University Medical Centre Göttingen in Germany, ICREA Research Professor Toni Gabaldón and his team at the Centre for Genomic Regulation in Barcelona read the genetic code of 33 separate strains of the yeast Candida glabrata, the second most common cause of candidiasis.

15 Dec 2017

Cellular self-digestion process plays role in development of autoimmune diseases

Autophagy allows cells to degrade and recycle their cellular components. Researchers at UZH have now demonstrated that the autophagy machinery in certain immune cells leads to the immune system attacking the central nervous system.

13 Dec 2017

Breakthrough research could lead to development of yeast-based protein therapies

It took several years, but a research team headed by Professor Jens Nielsen at Chalmers University of Technology has finally succeeded in mapping out the complex metabolism of yeast cells.

11 Dec 2017

Brazilian researchers identify genes linked to melanoma progression

When researchers at the University of São Paulo in Brazil treated human melanoma cell lines with a synthetic compound similar to curcumin, one of the pigments that give turmeric its orange color, they identified genes with altered expression in potentially invasive tumors and malignant cells resistant to chemotherapy.

6 Dec 2017

FDA grants approval to first biosimilar for treatment of patients with breast, stomach cancers

The U.S. Food and Drug Administration today approved Ogivri (trastuzumab-dkst) as a biosimilar to Herceptin (trastuzumab) for the treatment of patients with breast or metastatic stomach cancer (gastric or gastroesophageal junction adenocarcinoma) whose tumors overexpress the HER2 gene (HER2+).

4 Dec 2017