Neglected Tropical Disease News and Research

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USAID NTD Program funding cut by nearly 25% in proposed FY13 budget

"The United States Government has played a major role in ensuring that patients with certain [neglected tropical diseases (NTDs)] receive urgently needed treatments through the [USAID] NTD Program, while simultaneously being the largest funder of basic research for NTDs through the National Institutes of Health,"

30 Mar 2012

UI receives three grants to hasten discovery of new TB therapeutics

Forty-five years. That's how long it's been since the last drug - rifampin - hit the market to treat tuberculosis, an infection that affects nearly one third of the world's population and causes 1.8 million deaths annually. The University of Illinois at Chicago College of Pharmacy has received three new federally-funded grants to hasten the discovery of new therapeutic treatments.

23 Mar 2012

DNDi commences Oxaborole SCYX-7158 Phase I clinical trial for sleeping sickness

The Drugs for Neglected Diseases initiative (DNDi) has commenced a Phase I clinical trial in healthy adults in Paris, France, to determine the safety and tolerability of a promising oral drug candidate Oxaborole SCYX-7158, to treat human African trypanosomiasis (HAT, or sleeping sickness) for stage 1 and stage 2 of the disease.

12 Mar 2012

Study suggests onchocerciasis can be eliminated with sustained distribution of treatment

"New research supported by Sightsavers and the African Programme for Onchocerciasis Control (APOC) shows that yes, onchocerciasis really can be eliminated when treatment is distributed in an area for a sustained period" and "found that the disease may already be eliminated in one Nigerian state, marking a significant milestone for onchocerciasis control programs," the Global Network for Neglected Diseases' "End the Neglect" blog writes.

8 Mar 2012

Budget cuts threaten global health progress, advocacy group warns in report

The Global Health Technologies Coalition (GHTC) -- consisting of 40 global health research and advocacy organizations -- on Tuesday held a congressional briefing to launch its third annual policy report, titled "Sustaining Progress: Creating U.S. policies to spur global health innovation," GlobalPost's "Global Pulse" blog reports (Donnelly, 2/28).

1 Mar 2012

IDRI launches LEISH-F3 + GLA-SE Phase 1 trial for kala-azar

The first clinical trial of a new vaccine for visceral leishmaniasis (VL) has been launched by the Infectious Disease Research Institute (IDRI), a Seattle-based nonprofit that develops products to prevent, detect, and treat diseases of poverty. The Phase 1 trial is taking place in Washington State, with a companion Phase 1 trial planned in India, an epicenter of the disease.

23 Feb 2012

Administration officials announce new initiatives to promote innovations in global development

In a White House briefing on Wednesday, "senior Administration officials announced a series of new initiatives to promote game-changing innovations to solve long-standing development challenges" in response to President Obama's "call to harness science technology, and innovation to spark global development," Gayle Smith, special assistant to the president, and Tom Kalil, senior adviser for science, technology, and innovation, write in this post in the White House Blog.

10 Feb 2012

Economic transformation in Latin America an opportunity to improve NTD strategies, DNDi regional director says

"The rise of emerging economies in Latin America is an opportunity to improve strategies for fighting neglected illnesses and increase the region's contribution to the global struggle against them, says" Eric Stobbaerts, the Latin America director of the independent Drugs for Neglected Diseases initiative (DNDi), Inter Press Service reports.

7 Feb 2012

'Humanosphere' blog examines roles of former President Carter, researcher Foege in fighting NTDs

This post in KPLU 88.5's "Humanosphere" blog examines how former President Jimmy Carter gave the fight against neglected tropical diseases (NTDs) "a good first shove nearly 30 years ago," writing, "Neglected diseases like river blindness, Guinea worm, parasitic (lymphatic) elephantiasis and schistosomiasis have been in Carter's cross hairs since the mid-1980s."

4 Feb 2012

Researchers identify fexinidazole as potential new therapy for visceral leishmaniasis

Researchers at the University of Dundee have identified fexinidazole as a possible, much-needed, new treatment for the parasitic disease visceral leishmaniasis.

3 Feb 2012

Opinion pieces, blog react to new public-private NTD initiative

Pharmaceutical company heads and global health leaders gathered at a conference on Monday in London to announce the formation of a large public-private partnership to fight neglected tropical diseases (NTDs) and endorse the "London Declaration on Neglected Tropical Diseases", in which they pledged to work together and track progress.

1 Feb 2012

Large public-private partnership announced to speed progress against NTDs

Thirteen pharmaceutical companies; the governments of the U.S., U.K. and United Arab Emirates; the Bill & Melinda Gates Foundation; the WHO; the World Bank; the Drugs for Neglected Diseases initiative (DNDi); and other global health organizations "announced a new, coordinated push to accelerate progress toward eliminating or controlling 10 neglected tropical diseases (NTDs) by the end of the decade," according to a press release from Global Health Strategies.

31 Jan 2012

Abbott, DNDi partner to research on new treatments for NTDs

The Drugs for Neglected Diseases initiative (DNDi) and Abbott have signed a four-year joint research and non-exclusive licensing agreement to undertake research on new treatments for several of the world's most neglected tropical diseases, including Chagas disease, helminth infections, leishmaniasis and sleeping sickness.

31 Jan 2012

SCYNEXIS, MMV assemble Malaria Box of 400 compounds with antimalarial activity

In a bid to catalyse malaria and neglected disease drug discovery, MMV and SCYNEXIS, Inc. have assembled a Malaria Box of 400 carefully selected commercially available compounds with antimalarial activity and will provide it to researchers at no cost.

20 Dec 2011

New pediatric formula for Chagas disease treatment developed in Brazil

"A new pediatric formulation developed in Brazil holds out hope for a cure for over 90 percent of newborn babies infected with Chagas disease, a parasitic infection endemic in 21 Latin American countries, where it kills more people every year than malaria," Inter Press Service reports.

9 Dec 2011

Global health R&D funding from wealthy nations fell 6% in 2010, annual G-FINDER report finds

"A group that tracks funding for neglected diseases released its fourth annual report Wednesday, showing for the first time since 2007 a decrease in government and public spending in global health research and development," the Center for Global Health Policy's "Science Speaks" blog reports.

8 Dec 2011

Brazil's ANVISA grants registration for child-adapted formulation of benznidazole for Chagas disease

Today, at the occasion of the 4th DNDi Partners' Meeting in Rio de Janeiro, Brazil, Dr Carlos Gadelha, Secretary of Science, Technology and Strategic Products, Brazilian Ministry of Health, announced that Brazil's National Health Surveillance Agency (ANVISA) granted registration of a new paediatric dosage form of benznidazole, developed through a partnership between the Pernambuco State Pharmaceutical Laboratory (LAFEPE) of Brazil and the Drugs for Neglected Diseases initiative (DNDi).

3 Dec 2011

DNDi highlights lack of healthcare coverage for children with HIV/AIDS

Less than one-quarter (23%) of children with HIV/AIDS who need treatment are getting it, according to a report released by the World Health Organization (WHO) on the occasion of World AIDS Day.

2 Dec 2011

Five ways pharmaceutical companies can address NTDs

In this Forbes opinion piece, journalist Sarika Bansal examines five ways in which pharmaceutical companies can address neglected tropical diseases (NTDs), including creating cross-sectorial research partnerships for neglected diseases; joining patent pools for neglected diseases; donating drugs for neglected diseases; creating facilities dedicated to neglected disease research; and allowing scientists to work on neglected disease, both formally and informally.

24 Nov 2011

Oral antibiotics might treat Buruli ulcer

It might be possible to treat Buruli ulcer, a crippling and deforming disease, with only oral medicines, which would make treatment easier. And even the current treatment can in many cases be given in an outpatient regimen.

23 Nov 2011