Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Machine learning approach sheds light on the biology of liver and kidneys after toxin exposure

Exposure to potentially harmful chemicals is a reality of life. Our ancestors, faced with naturally occurring toxins, evolved mechanisms to detoxify and expel damaging substances.

15 Mar 2019

New clinical development user's guide for kidney safety biomarkers

The Critical Path Institute's (C-Path) Predictive Safety Testing Consortium (PSTC) today announced availability of the User's Guide: Kidney Safety Composite Measure Biomarker for Use in Clinical Development.

15 Mar 2019

Cell therapy may be alternative strategy for treatment of chronic kidney disease

Wake Forest Institute for Regenerative Medicine scientists are working on a promising approach for treatment of chronic kidney disease - regeneration of damaged tissues using therapeutic cells.

15 Mar 2019

Long-awaited structure offers new insights into rejection of transplanted organs

Rejection of any kind is always hard to deal with, but when one's body rejects a precious organ transplant, the consequences can be devastating. Professor A. Vathsala, Co-director of the National University Centre for Organ Transplantation at the National University Hospital and Professor of Medicine, shared that between 30% to 40% of kidney transplants are lost over time to rejection.

15 Mar 2019

Antiviral treatment improves survival for kidney transplant recipients infected with HBV or HCV

Prior to the development of antiviral therapy, kidney transplant recipients infected with either hepatitis B or hepatitis C experienced poor outcomes.

15 Mar 2019

Exosomes are key to SOS signal that the heart muscle sends out after heart attack, study reveals

Human cells shed exosomes. These tiny extracellular, membrane-bound vesicles can carry cargo for cell-to-cell communication, ferrying diverse loads of proteins, lipids or nucleic acids.

14 Mar 2019

“Fail Fast, But More Confidently”: Developing Organoids for Drug Development and Discovery

Richard Eglen discusses the use of organoids in drug discovery, including the screening of candidate compounds for efficacy, toxicity, and pharmacokinetics.

From Corning Life Sciences 13 Mar 2019

Study provides new understanding about blood pressure control in older adults

Until recently, physicians had generally assumed that older adults benefit from keeping their blood pressure below 140/90 mmHg. However, researchers from Charité - Universitätsmedizin Berlin have now found that this assumption does not apply to all patients with high blood pressure.

12 Mar 2019

Managing nontraditional risk factors to improve outcomes after cancer surgery

In a study of 142 patients preparing for cancer surgery, Johns Hopkins Medicine researchers say they have evidence that psychological or social risk factors such as depression, limited resilience and lack of emergency resources along with standard medical risk factors such as high blood pressure or diabetes are linked with higher risks of surgical complications.

12 Mar 2019

Computational model of the human kidney could provide safer tests for new drugs

A University of Waterloo researcher has spearheaded the development of the first computational model of the human kidney.

12 Mar 2019

$2.7 million grant supports UIC researchers to study role of arsenic in development of diabetes

A five-year, $2.7 million grant from the National Institute of Environmental Health Sciences will help researchers at the University of Illinois at Chicago answer basic questions about the role of arsenic in the development of diabetes and examine the mechanisms by which selenoproteins – found in the human body in 25 different forms – counter the effects of arsenic.

11 Mar 2019

Tiny implantable 'tea bag' senses glucose levels and automatically releases insulin

Children with Type 1 diabetes have only one option to control their blood sugar: insulin treatment. Ravaged by an autoimmune disease that attacks their own pancreas and islets -- microscopic clusters of cells that sense blood sugar and produce insulin -- patients are forced to rely on insulin from an external source.

11 Mar 2019

New guidelines on clinical use of life-saving antibiotics

An international panel of the foremost researchers on infectious disease and antimicrobials has formed new guidelines on the use of polymyxins, a class of antibiotics employed as a last resort to treat deadly, drug-resistant bacteria.

11 Mar 2019

Zinc could help develop new non-antibiotic treatment for bacterial diseases

New details about the role of zinc in our immune system could help the development of new non-antibiotic treatment strategies for bacterial diseases, such as urinary tract infections.

9 Mar 2019

Research shows how SGLT-2 inhibitors induce a fasting state that triggers metabolic benefits

SGLT-2 inhibitors are a relatively new class of diabetes drugs that have shown many benefits for people with type 2 diabetes who have not responded well to previous interventions, including diet changes and metformin.

8 Mar 2019

CAR-T cell therapy could be on the horizon for patients with lupus

Researchers have developed a novel CAR-T cell therapy that can reduce B cell numbers known to cause the inflammatory responses in lupus.

7 Mar 2019

Better regulation of the immune system may help manage preeclampsia

Boosting the body's levels of interleukin-4 (IL-4)--an immune system protein that controls inflammation--may help manage the pregnancy complication preeclampsia, according to a new rodent study.

7 Mar 2019

Smartphone app for remote blood pressure monitoring shows promise

People with both diabetes and uncontrolled high blood pressure who used a smartphone app to monitor their blood pressure remotely, get tips on healthful living and connect with a health coach saw significant declines in their blood pressure within six weeks, according to research being presented at the American College of Cardiology's 68th Annual Scientific Session.

7 Mar 2019

Loss of Medicare coverage associated with kidney transplant outcomes

Kidney transplant recipients under 65 years of age qualify for Medicare coverage following transplantation, but coverage ends after three years. A new American Journal of Transplantation study found that failure of the transplanted kidney was 990 percent to 1630 percent higher for recipients who lost Medicare coverage before this three-year time point compared with recipients who lost Medicare on time.

7 Mar 2019

Study uses AI to analyze risk factors in type 1 diabetes

In combination with conventional statistical methods, artificial intelligence has now been used in a study of risk factors in type 1 diabetes. The objective was to identify the most important indicators of elevated risk for cardiovascular disease and death.

6 Mar 2019

Nephrology News and Research

Further Reading

Machine learning approach sheds light on the biology of liver and kidneys after toxin exposure

New clinical development user's guide for kidney safety biomarkers

Cell therapy may be alternative strategy for treatment of chronic kidney disease

Long-awaited structure offers new insights into rejection of transplanted organs

Antiviral treatment improves survival for kidney transplant recipients infected with HBV or HCV

Exosomes are key to SOS signal that the heart muscle sends out after heart attack, study reveals

“Fail Fast, But More Confidently”: Developing Organoids for Drug Development and Discovery

Study provides new understanding about blood pressure control in older adults

Managing nontraditional risk factors to improve outcomes after cancer surgery

Computational model of the human kidney could provide safer tests for new drugs

$2.7 million grant supports UIC researchers to study role of arsenic in development of diabetes

Tiny implantable 'tea bag' senses glucose levels and automatically releases insulin

New guidelines on clinical use of life-saving antibiotics

Zinc could help develop new non-antibiotic treatment for bacterial diseases

Research shows how SGLT-2 inhibitors induce a fasting state that triggers metabolic benefits

CAR-T cell therapy could be on the horizon for patients with lupus

Better regulation of the immune system may help manage preeclampsia

Smartphone app for remote blood pressure monitoring shows promise

Loss of Medicare coverage associated with kidney transplant outcomes

Study uses AI to analyze risk factors in type 1 diabetes

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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