Neurodegeneration News and Research

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Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.

Neuronal death and processing of Tau protein in Alzheimer’s Disease (AD)

In a research report recently published in the Journal of Alzheimer's Disease, published by IOS Press, a research group from the International School for Advanced Studies (ISAS\SISSA) in Trieste (Luisa Fasulo, Gabriele Ugolini e Antonino Cattaneo) showed that a processed form of tau protein induces neuronal death by apoptosis (programmed cell death) when expressed in cultured rat hippocampal neurons.

15 Mar 2005

High-dose radiation and bone marrow transfer treatments on glaucoma-susceptible mice completely blocked development of glaucoma

In a discovery that could point to new treatments for a wide range of neurodegenerative diseases, Jackson Laboratory researchers have found that high-dose radiation and bone marrow transfer treatments on glaucoma-susceptible mice completely blocked the development of glaucoma, by preventing neurodegeneration.

14 Mar 2005

Commonly used anesthetic regimen appears to have no negative effects on the developing brain of the fetus

An anesthetic regimen commonly used during surgery on pregnant mothers appears to have no negative effects on the developing brain of the fetus, according to a new study on sheep conducted by Duke University Medical Center researchers.

9 Mar 2005

Common anesthetics appear safe for developing fetal brain

A group of Dartmouth researchers has learned that the brain's auditory cortex, the part that handles information from your ears, holds on to musical memories.

9 Mar 2005

Insulin levels linked to Alzheimer's disease

Insulin and its related proteins are produced in the brain, and according to researchers from Rhode Island Hospital and Brown Medical School, reduced levels of this combination can be linked to Alzheimer's disease. The findings are reported in the March issue of the Journal of Alzheimer's Disease.

7 Mar 2005

Gene variant that may increase the risk of late-onset Alzheimer's disease

Researchers from the MassGeneral Institute for Neurodegenerative Disorders (MIND) have identified a gene variant that may increase the risk of late-onset Alzheimer's disease.

2 Mar 2005

How polychlorinated biphenyls open brain cells to Parkinson's assault

University of Rochester scientists investigating the link between PCBs, pesticides and Parkinson's disease demonstrated new and intricate reactions that occur in certain brain cells, making them more vulnerable to injury after exposures.

9 Feb 2005

Single gene mutation as the cause of around one in 25 cases of Parkinson’s disease worldwide

The studies suggest that the mutation, in a recently discovered gene called LRRK2, causes around 5% of inherited Parkinson’s cases and around 2% of isolated cases. Screening for the new mutation is likely to become a component of genetic testing for Parkinson’s disease in the near future.

17 Jan 2005

Stem cells use inflammatory signals to find injured tissue

A joint effort led by stem cell biologist Evan Y. Snyder, M.D., Ph.D., of The Burnham Institute, and Samia J. Khoury, M.D., of Harvard Medical School and Brigham and Women’s Hospital, report data suggesting that stem cells use inflammatory signals to “know” where they must home.

20 Dec 2004

Marijuana-like compounds may aid Parkinson's disease, pain and obesity

No longer a pipe dream, new animal research now indicates that marijuana-like compounds can aid a bevy of debilitating conditions, ranging from brain disorders such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease, to pain and obesity.

28 Oct 2004

Robotic microscope shows how mutant Huntington's disease protein affects neurons

Using a specially designed robotic microscope to study cultured cells, researchers have found evidence that abnormal protein clumps called inclusion bodies in neurons from people with Huntington's disease (HD) prevent cell death.

13 Oct 2004

Duplication of the alpha-synuclein gene causes Parkinson's disease in a French family

In affected individuals, age of onset, symptoms and symptom progression are similar to that observed in people with sporadic or unexplained cases of Parkinson's disease.

27 Sep 2004

Disruption of protein folding causes neurodegeneration, mental retardation

Excess accumulation in brain cells of a fat molecule called GM1-ganglioside (GM1) disrupts the folding of newly assembled proteins into their proper shapes, triggering nerve degeneration and mental retardation in children.

10 Sep 2004

Researchers have shown that an experimental vaccine can reduce the amount of neurodegeneration in a mouse model for Parkinson's disease

The finding suggests that a similar therapy might eventually be able to slow the devastating course of Parkinson's disease in humans.

29 Jul 2004

Embryonic cell implantation improves motor skills in patients with Parkinson's disease

Patients with Parkinson disease (PD) who underwent treatment involving embryonic cell implantation had better motor functioning after their procedures than PD patients who did not receive embryonic cells

21 Jun 2004

Nordic networks to explore Parkinson’s, Alzheimer’s, stroke, migraine, epilepsy, cancer and autoimmune and metabolic disorders

Parkinson’s, Alzheimer’s, stroke, migraine, epilepsy, cancer and autoimmune and metabolic disorders – these are examples of diseases that will be explored by the three Nordic networks that have been granted financial support from the joint Nordic venture ”Nordic Centre of Excellence Programme in Molecular Medicine”.

15 Jun 2004

Neurodegeneration News and Research

Further Reading

Neuronal death and processing of Tau protein in Alzheimer’s Disease (AD)

High-dose radiation and bone marrow transfer treatments on glaucoma-susceptible mice completely blocked development of glaucoma

Commonly used anesthetic regimen appears to have no negative effects on the developing brain of the fetus

Common anesthetics appear safe for developing fetal brain

Insulin levels linked to Alzheimer's disease

Gene variant that may increase the risk of late-onset Alzheimer's disease

How polychlorinated biphenyls open brain cells to Parkinson's assault

Single gene mutation as the cause of around one in 25 cases of Parkinson’s disease worldwide

Stem cells use inflammatory signals to find injured tissue

Marijuana-like compounds may aid Parkinson's disease, pain and obesity

Robotic microscope shows how mutant Huntington's disease protein affects neurons

Duplication of the alpha-synuclein gene causes Parkinson's disease in a French family

Disruption of protein folding causes neurodegeneration, mental retardation

Researchers have shown that an experimental vaccine can reduce the amount of neurodegeneration in a mouse model for Parkinson's disease

Embryonic cell implantation improves motor skills in patients with Parkinson's disease

Nordic networks to explore Parkinson’s, Alzheimer’s, stroke, migraine, epilepsy, cancer and autoimmune and metabolic disorders

Pathogens have the ability to cause late-onset sporadic Alzheimer's disease

Parkinson's disease breakthrough

There are still benefits from hormone therapy after menopause

Aneuro: A Year of Neuroscience in Review eBook

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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